Systematic review of ghrelin response to food intake in pediatric age, from neonates to adolescents

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 5, 2014, Pages 1556-1568

  Prodam, Flavia ^a   Monzani, Alice ^a   Ricotti, Roberta ^a   Marolda, Agostina ^a   Bellone, Simonetta ^a   Aimaretti, Gianluca ^a   Roccio, Marta ^a   Bona, Gianni ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GLUCOSE;

AGE DISTRIBUTION; ARTICLE; CHILDHOOD OBESITY; DATA ANALYSIS; DISEASE ASSOCIATION; FOOD INTAKE; HORMONAL REGULATION; HORMONE DETERMINATION; HORMONE RELEASE; HORMONE RESPONSE; HUMAN; LEAN BODY WEIGHT; MEAL; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PUBLICATION; QUALITY CONTROL; SCORING SYSTEM; SYSTEMATIC REVIEW;

ADOLESCENT; BODY WEIGHT; CHILD; CHILD, PRESCHOOL; EATING; GHRELIN; HUMANS; OBESITY; POSTPRANDIAL PERIOD;

EID: 84899937386     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-4010     Document Type: Article

References (81)

1. Adams CE, Greenway FL, Brantley PJ. Lifestyle factors and ghrelin: critical review and implications for weight loss maintenance. Obes Rev. 2011;12:e211-e218.
2. Delhanty PJ, Neggers SJ, van der Lely AJ. Mechanisms in endocrinology: ghrelin: The differences between acyl-and des-acyl ghrelin. Eur J Endocrinol. 2012;167:601-608.
3. Kojima M Hosoda H Date Y Nakazato M Matsuo H Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature. 1999 402 656-660.
4. van der Lely AJ, Tschöp M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev. 2004;25:426-457.
5. Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev. 2005;85:495-522.
6. Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB. Ghrelin-A hormone with multiple functions. Front Neuroendocrinol. 2004;25:27-68.
7. Caballero B. A nutrition paradox-underweight and obesity in developing countries. N Engl J Med. 2005;352:1514-1516.
8. Yang J, Br own MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetitestimulating peptide hormone. Cell. 2008;132:387-396.
9. Leite-Moreira AF, Soares JB. Physiological, pathological and potential therapeutic roles of ghrelin. Drug Discov Today. 2007;12: 276-288.
10. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, We igle DS.Apreprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 2001;50:1714-1719.
11. Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature. 2000;407:908-913.
12. Wiedmer P, Nogueiras R, Broglio F, D'Alessio D, Tschöp MH. Ghrelin, obesity and diabetes. Nat Clin Pract Endocrinol Metab. 2007;3:705-712 .
13. Shintani M, Ogawa Y, Ebihara K, et al. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 r eceptor pathway. Diabetes. 2001;50:227-232.
14. Chen HY, Trumbauer ME, Chen AS, et al. Orexigenic action of peripheral ghrelin is mediated by neuropeptideYand agouti-related protein. Endocrinology. 2004;145:2607-2612.
15. Zorrilla EP, Iwasaki S, Moss JA, et al. Vaccination against weight gain. Proc Natl Acad Sci USA. 2006;103:13226-13231.
16. H eppner KM, Chaudhary N, Müller TD, et al. Acylation type determines ghrelin's effects on energy homeostasis in rodents. Endocrinology. 2012;153:4687-4695.
17. Cummings DE. Ghrelin and the short-and long-term regulation of appetite and body weight. Physiol Behav. 2006;89:71-84.
18. Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes. 2001;50:707-709.
19. Goebel-Stengel M, Hofmann T, Elbelt U, et al. The ghrelin activating enzyme ghrelin-O-acyltransferase (GOAT) is present in human plasma and expressed dependent on body mass index. Peptides. 2013;43:13-19.
20. Teubner BJ, Garretson JT, Hwang Y, Cole PA, Bartness TJ. Inhibition of ghrelin O-acyltransferase attenuates food deprivation-induced increases in ingestive behavior. Horm Behav. 2013;63 :667-673.
21. Davis JF, PerelloM,Choi DL, et al.GOATinduced ghrelin acylation regulates hedonic feeding. Horm Behav. 2012;62:598-604.
22. Perreault M, Istrate N, Wa ng L, Nichols AJ, Tozzo E, Stricker-Krongrad A. Resistance to the orexigenic effect of ghrelin in dietaryinduced obesity in mice: reversal upon weight loss. Int J Obes Relat Metab Disord. 2004;28:879-885.
23. Yildiz BO, Suchard MA, Wong ML, McCann SM, Licinio J. Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. Proc Natl Acad Sci USA. 2004;101:10434-10439.
24. Vazquez Roque MI, Camilleri M, Stephens DA, Jensen MD, Burton DD, Baxter KL, Zinsmeister AR. Gastric sensorimotor functions and hormone profile in normal weight, overweight, and obese people. Gastroent erology. 2006;131:1717-1724.
25. English PJ Ghatei MA Malik IA Bloom SR Wilding JP. Food fails to suppress ghrelin levels in obese humans J Clin Endocrinol Metab. 2002 87: 2984-2987.
26. Yi CX, Heppner K, Tscho ̈p MH. Ghrelin in eating disorders. Mol Cell Endocrinol. 2011;340:29-34.
27. Kim MS, Yoon CY, Park KH, et al. Changes in ghrelin and ghrelin receptor expression according to feeding status. Neuroreport. 2003; 14:1317-1320.
28. Muller AF, Lamberts SW, Janssen JA, et al. Ghrelin drives GH secretion during fasting in man. Eur J Endocrinol. 2002;146:203-207.
29. Natalucci G, Riedl S, Gleiss A, Zidek T, FrisHsieh C.H. Spontaneous 24-h ghrelin secretion pattern in fasting subjects: maintenance of a mealrelated pattern. Eur J Endocrinol. 2005;152:845-850.
30. Avram AM, Jaffe CA, Symons KV, Barkan AL. Endogenous circulating ghrelin does not mediate growth hormone rhythmicity or response to fasting. J Clin Endocrinol Metab. 2005;90:2982-2987.
31. Espelund U, Hansen TK, Højlund K, et al. Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects. J Clin Endocrinol Metab. 2005; 90:741-746.
32. Liu J, Prudom CE, Nass R, et al. Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men. J Clin Endocrinol Metab. 2008;93:1980-1987.
33. N ass R, Farhy LS, Liu J, et al. Evidence for acyl-ghrelin modulation of growth hormone release in the fed state. J Clin Endocrinol Metab. 2008;93:1988-1994.
34. Kirchner H, Gutierrez JA, S olenberg PJ, et al. GOAT links dietary lipids with the endocrine control of energy balance. Nat Med. 2009; 15:741-745.
35. Prodam F, Me E, Riganti F, et al. The nutritional control of ghrelin secretion in humans: The effects of enteral vs. parenteral nutrition. Eur J Nutr. 2006;45:399-405.
36. Wells G, Shea B, O'Connell D, et al. The Newcastle Ottawa Scale (NOS) for assessing th e quality of nonrandomized studies in metaanalysis. http://www.ohri.ca/programs/clinical-epidemiology/nosgen. pdf, Ottawa Health Research Institute; 1999.
37. Bellone S, Baldelli R, Radetti G, et al. Ghrelin secretion in preterm neonates progressively increases and is refractory to the inhibitory effect of food intake. J Clin Endocrinol Metab. 2006;91:1929-1933.
38. Iniguez G,OngK, Pena V, Avila A, Du nger D, Mericq V. Fasting and post-glucose ghrelin levels in SGA infants: relationships with size and weight gain at one year of age. J Clin Endocrinol Metab. 2002; 87:5830-5833.
39. Hübler A, Rippel C, Kauf E, et al. Associations between ghrelin levels in serum of preterm infants and enteral nutritional state during the first 6 months after birth. Clin Endocrinol (Oxf). 2006;65:611-616.
40. Bizzarri C, Rigamonti AE, Lu ce A, et al. Children with Prader-Willi syndrome exhibit more evident meal-induced responses in plasma ghrelin and peptide YY levels than obese and lean children. Eur J Endocrinol. 2010;162:499-505.
41. Stock S, Leichner P, Wong AC, et al. Ghrelin, peptide YY, glucosedependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents. J Clin Endocrinol Metab. 2005;9 0:2161-2168.
42. Misra M, Tsai PM, Mendes N, Miller KK, Klibanski A. Increased carbohydrate induced ghrelin secretion in obese vs. normal-weight adolescent girls. Obesity (Silver Spring). 2009;17:1689-1695.
43. Bellone S, Castellino N, Broglio F, et al. Ghrelin secretion in childhood is refractory to the inhibitory effect of feeding. J Clin Endocrinol Metab. 2004;89:1662-1665.
44. Lomenick JP, Clasey JL, Anderson JW. Meal-related changes in ghrelin, peptide YY, and appetite in normal weight and overweight children. Obesity (Silver Spring). 2008;16:547-552.
45. Prodam F, Trovato L, Demarchi I, et al. Unacylated, acylated ghrelin and obestatin levels are differently inhibited by oral glucose load in pediatric obesity: association with insulin sensitivity and metabolic alterations. e-SPE N. 2011;6:e109-e115.
46. Baldelli R Bellone S Castellino N et al. Oral glucose load in hibits circulating ghrelin levels to the same extent in normal and obese children Clin Endocrinol (Oxf). 2006 64 255-259.
47. Bacha F, Arslanian SA. Ghrelin suppression in overweight children: a manifestation of insulin resistance J Clin Endocrinol Metab. 2005;90:2725-2730.
48. Chandler-Laney PC, Bush NC, Rouse DJ, Mancuso MS, Gower BA. Gut hormone activity of children born to women with and without gestational diabetes [published online January 31, 2013]. Pediatr Obes. doi:10.1111/j.2047-6310.2012. 00140.x.
49. Maffeis C, Bonadonna RC, Consolaro A, et al. Ghrelin, insulin sensitivity and postpr andial glucose disposal in overweight and obese children. Eur J Endocrinol. 2006;154:61-68.
50. Maffeis C, Surano MG, Cordioli S, Gasperotti S, Corradi M, Pinelli L.Ahigh-fat vs. A moderate-f at meal in obese boys: nutrient balance, appetite, and gastrointestinal hormone changes. Obesity (Silver Spring). 2010;18:449-455.
51. Maffeis C, Fornari E, Surano MG, et al. Breakfast skipping in prepubertal obese children: hormonal, metabolic and cognitive consequences. Eur J Clin Nutr. 2012;66:314-321.
52. Rigamonti AE, Agosti F, De Col A, et al. Changes in plasma levels of ghrelin, leptin, and other hormonal and metabolic parameters following standardized breakfast, lunch, and physical exercise before and after a multidisciplinary weight-reduction intervention in obese adolescents. J Endocrinol Invest. 2010;33:633-639.
53. Mittelman SD, Klier K, Braun S, Azen C, Geffner ME, Buchanan TA. Obese adolescents show impaired meal responses of the appetite-regulating hormones ghrelin and PYY. Obesity (Silver Spring). 2010;18:918-925.
54. Ellis AC, Casazza K, Chandler-Laney P, Gower BA. Higher postprandial serum ghrelin among African-American girls before puberty. J Pediatr Endocrinol Metab. 2012;25:691-696.
55. Soriano-Guillén L, Barrios V, Martos G, Chowen JA, Campos-Barros A, Argente J. Effect of oral glucose administration on ghrelin levels in obese children. Eur J Endocrinol. 2004;151:119-121.
56. Gil-Campos M, Aguilera CM, Ramirez-Tortosa MC, Canete R, Gil A. Fasting and postprandial relationships among plasma leptin, ghrelin, and insulin in prepubertal obese children. Clin Nutr. 2010; 29:54-59.
57. Martos-Moreno GA, Barrios V, Martínez G, Hawkins F, Argente J. Acylated ghrelin levels in pre-pubertal obese children at diagnosis and after weight reduction: effect of oral glucos e ingestion. J Endocrinol Invest. 2011;34:117-123.
58. O'Gorman CS, Simoneau-Roy J, PencharzMbP, Adeli K, Hamilton J. Delayed ghrelin suppression following oral glucose tolerance test in childre n and adolescents with hypothalamic injury secondary to craniopharyngioma compared with obese controls. Int J Pediatr Obes. 2011;6:285-288.
59. Wang XM, Jiang YJ, Liang L, Du LZ. Changes of ghre lin following oral glucose tolerance test in obese children with insulin resistance. World J Gastroenterol. 2008;14:1919-1924.
60. Roth CL, Bongiovanni KD, Gohlke B, Woelfle J. Changes in dynamic insulin and gastrointestinal hormone secretion in obese children. J Pediatr Endocrinol Metab. 2010;23:1299-1309.
61. Galli-Tsinopoulou A, Stylianou C, Farmakiotis D, Rousso I, Karamouzis M, Nousia-Arvanitakis S. Ghrelin serum levels during oral glucose tolerance test in prepubertal obese children with insulin resistance. J Pediatr E ndocrinol Metab. 2007;20:1085-1092.
62. Lányi E, Csernus K, Erhardt E, et al. Plasma levels of acylated ghrelin during an oral glucose tolerance test in obese children. J Endocrinol Invest. 2007;30:133-137.
63. Paik KH, Choe YH, Park WH, et al. Suppression of acylated ghrelin during oral glucose tolerance test is correlated with whole-body insulin sensitivity in children with Prader-Willi syn drome. J Clin Endocrinol Metab. 2006;91:1876-1881.
64. Galhardo J, Hunt LP, Lightman SL, et al. Normalizing eating behavior reduces body weight and improves gastrointestinal hormonal secretion in obese adolescents. J Clin Endocrinol Metab. 2012;97: E19 3-E201.
65. Paik KH, Jin DK, Song SY, et al. Correlation between fasting plasma ghrelin levels and age, body mass index (BMI), BMI percentiles, and 24-hour plasma ghrelin profiles in Prader-Willi syndrome. J Cli n Endocrinol Metab. 2004;89:3885-3889.
66. Paik KH, Lee MK, Jin DK, et al. Marked suppression of ghrelin concentration by insulin in Prader-Willi syndrome. J Korean Med Sci. 2007;22:177-182.
67. Bizzarri C Rigamonti AE Giannone G et al. Maintenance of a normal meal-induced decrease in plasma ghrelin levels in children with Prader-Willi syndrome Horm Metab Res. 2004 36: 164-169.
68. Chanoine JP, Wong AC. Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: effect of maternal fasting. Endocrinology. 2004;145:3813-3820.
69. Wierup N, Svensson H, Mulder H, Sundler F. The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept. 2002;107:63-69.
70. Ni H, Walia P, Chanoine JP. Ontogeny of acylated ghrelin degradation in the rat. Peptides. 2010;31:301-306.
71. Tannenbaum GS, Ramsay M, Martel C, et al. Elevated circulating acylated and total ghrelin concentrations along with reduced appetite scores in infants with failure to thrive. Pediatr Res. 2009;65: 569-573.
72. Pinsker JE, Ondrasik D, Chan D, et al. Total and acylated ghrelin levels in children with poor growth. Pediatr Res. 2011;69:517-521.
73. Briggs DI, Andrews ZB. A recent update on the role of ghrelin in glucose homeostasis. Curr Diabetes Rev. 2011;7:201-207.
74. Leidy HJ, Ortinau LC, Douglas SM, Hoertel HA. Beneficial effects of a higher-protein breakfast on the appetitive, hormonal, and neural signals controlling energy intake regulation in overweight/obese, "breakfast- skipping, " late-adolescent girls. Am J Clin Nutr. 2013; 97:677-688.
75. Blatnik M, Soderstrom CI. A practical guide for the stabilization of acylghrelin in human blood collections. Clin Endocrinol (Oxf). 2011;74:325-331.
76. McLaughlin T, Abbasi F, Lamendola C, Frayo RS, Cummings DE. Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls. J Clin Endocrinol Metab. 2004;89:1630-1635.
77. Erdmann J, Töpsch R, Lippl F, Gussmann P, Schusdziarra V. Postprandial response of plasma ghrelin levels to various test m eals in relation to food intake, plasma insulin, and glucose. J Clin Endocrinol Metab. 2004;89:3048-3054.
78. Foster-Schubert KE, Overduin J, Prudom CE, et al. Acyl and total ghrelin are suppress ed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates. J Clin Endocrinol Metab. 2008;93:1971-1979.
79. Dezaki K, Sone H, Yada T. Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis. Pharmacol Ther. 2008;118:239-249.
80. Broglio F, Prodam F, Riganti F, et al. The continuous infusion of acylated ghrelin enhances g rowth hormone secretion and worsens glucose metabolism in humans. J Endocrinol Invest. 2008;31:788-794.
81. DelParigi A, Tschöp M, Heiman ML, et al. High circulating ghrelin: a potential cause for hyperphagia and obesity in Prader-Willi syndrome. J Clin Endocrinol Metab. 2002;87:5461-5464.