메뉴 건너뛰기




Volumn 7, Issue 3, 2011, Pages 201-207

A recent update on the role of ghrelin in glucose homeostasis

Author keywords

Acyl ghrelin; Des acyl ghrelin; Glucose; Glucose stimulated insulin secretion; Goat; Insulin; Insulin sensitivity; Pancreas

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; GHRELIN; GLUCOSE; INSULIN; POTASSIUM CHANNEL;

EID: 79959349088     PISSN: 15733998     EISSN: 18756417     Source Type: Journal    
DOI: 10.2174/157339911795843140     Document Type: Review
Times cited : (27)

References (61)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402(6762): 656-60.
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 2
    • 9444246501 scopus 로고    scopus 로고
    • A receptor in pituitary and hypothalamus that functions in growth hormone release
    • Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996; 273(5277): 974-7.
    • (1996) Science , vol.273 , Issue.5277 , pp. 974-977
    • Howard, A.D.1    Feighner, S.D.2    Cully, D.F.3
  • 3
    • 0030762351 scopus 로고    scopus 로고
    • Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues
    • Guan XM, Yu H, Palyha OC, et al. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res 1997; 48(1): 23-9.
    • (1997) Brain Res Mol Brain Res , vol.48 , Issue.1 , pp. 23-29
    • Guan, X.M.1    Yu, H.2    Palyha, O.C.3
  • 4
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008; 132(3): 387-96.
    • (2008) Cell , vol.132 , Issue.3 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 5
    • 33846024377 scopus 로고    scopus 로고
    • On the processing of proghrelin to ghrelin
    • Zhu X, Cao Y, Voogd K, Steiner DF. On the processing of proghrelin to ghrelin. J Biol Chem 2006; 281(50): 38867-70.
    • (2006) J Biol Chem , vol.281 , Issue.50 , pp. 38867-38870
    • Zhu, X.1    Cao, Y.2    Voogd, K.3    Steiner, D.F.4
  • 6
    • 0034809159 scopus 로고    scopus 로고
    • Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration
    • Toshinai K, Mondal MS, Nakazato M, et al. Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun 2001; 281(5): 1220-5.
    • (2001) Biochem Biophys Res Commun , vol.281 , Issue.5 , pp. 1220-1225
    • Toshinai, K.1    Mondal, M.S.2    Nakazato, M.3
  • 7
    • 0036686347 scopus 로고    scopus 로고
    • Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats
    • Murakami N, Hayashida T, Kuroiwa T, et al. Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats. J Endocrinol 2002; 174(2): 283-8.
    • (2002) J Endocrinol , vol.174 , Issue.2 , pp. 283-288
    • Murakami, N.1    Hayashida, T.2    Kuroiwa, T.3
  • 8
    • 77952165770 scopus 로고    scopus 로고
    • Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorierestricted mice
    • Zhao T-J, Liang G, Li RL, et al. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorierestricted mice. Proc Natl Acad Sci 2010; 107(16): 7467-72.
    • (2010) Proc Natl Acad Sci , vol.107 , Issue.16 , pp. 7467-7472
    • Zhao, T.-J.1    Liang, G.2    Li, R.L.3
  • 9
    • 38549133092 scopus 로고    scopus 로고
    • Characterization of Adult Ghrelin and Ghrelin Receptor Knockout Mice under Positive and Negative Energy Balance
    • Sun Y, Butte NF, Garcia JM, Smith RG. Characterization of Adult Ghrelin and Ghrelin Receptor Knockout Mice under Positive and Negative Energy Balance. Endocrinology 2008; 149(2): 843-50.
    • (2008) Endocrinology , vol.149 , Issue.2 , pp. 843-850
    • Sun, Y.1    Butte, N.F.2    Garcia, J.M.3    Smith, R.G.4
  • 10
    • 2542597708 scopus 로고    scopus 로고
    • Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference
    • Wortley KE, Anderson KD, Garcia K, et al. Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci USA 2004; 101(21): 8227-32.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.21 , pp. 8227-8232
    • Wortley, K.E.1    Anderson, K.D.2    Garcia, K.3
  • 11
    • 31044452189 scopus 로고    scopus 로고
    • Absence of ghrelin protects against early-onset obesity
    • Wortley KE, del Rincon J-P, Murray JD, et al. Absence of ghrelin protects against early-onset obesity. J Clin Invest 2005; 115(12): 3573-8.
    • (2005) J Clin Invest , vol.115 , Issue.12 , pp. 3573-3578
    • Wortley, K.E.1    del Rincon, J.-P.2    Murray, J.D.3
  • 12
    • 31044451759 scopus 로고    scopus 로고
    • Mice lacking ghrelin receptors resist the development of diet-induced obesity
    • Zigman JM, Nakano Y, Coppari R, et al. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest 2005; 115(12): 3564-72.
    • (2005) J Clin Invest , vol.115 , Issue.12 , pp. 3564-3572
    • Zigman, J.M.1    Nakano, Y.2    Coppari, R.3
  • 13
    • 33646141847 scopus 로고    scopus 로고
    • Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    • Sun Y, Asnicar M, Saha P, Chan L, Smith R. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 2006; 3: 379-86.
    • (2006) Cell Metab , vol.3 , pp. 379-386
    • Sun, Y.1    Asnicar, M.2    Saha, P.3    Chan, L.4    Smith, R.5
  • 14
    • 51249105332 scopus 로고    scopus 로고
    • Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice
    • Longo K, Charoenthongtrakul S, Giuliana D, Govek E, McDonagh T. Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice. Regul Pept 2008; 150: 55-61.
    • (2008) Regul Pept , vol.150 , pp. 55-61
    • Longo, K.1    Charoenthongtrakul, S.2    Giuliana, D.3    Govek, E.4    McDonagh, T.5
  • 15
    • 78650869242 scopus 로고    scopus 로고
    • Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps
    • Qi Y, Longo K, Giuliana D, et al. Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps. BMC Physiol 2011; 11(1): 1.
    • (2011) BMC Physiol , vol.11 , Issue.1 , pp. 1
    • Qi, Y.1    Longo, K.2    Giuliana, D.3
  • 16
    • 9444264700 scopus 로고    scopus 로고
    • Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: Implication in the glycemic control in rodents
    • Dezaki K, Hosoda H, Kakei M, et al. Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents. Diabetes 2004; 53(12): 3142-51.
    • (2004) Diabetes , vol.53 , Issue.12 , pp. 3142-3151
    • Dezaki, K.1    Hosoda, H.2    Kakei, M.3
  • 17
    • 78650304822 scopus 로고    scopus 로고
    • Glucose and weight control in mice with a designed ghrelin o-acyltransferase inhibitor
    • Barnett BP, Hwang Y, Taylor MS, et al. Glucose and weight control in mice with a designed ghrelin o-acyltransferase inhibitor. Science 2010; 330(6011): 1689-92.
    • (2010) Science , vol.330 , Issue.6011 , pp. 1689-1692
    • Barnett, B.P.1    Hwang, Y.2    Taylor, M.S.3
  • 18
    • 0038304457 scopus 로고    scopus 로고
    • Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
    • Asakawa A, Inui A, Kaga T, et al. Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gut 2003; 52(7): 947-52.
    • (2003) Gut , vol.52 , Issue.7 , pp. 947-952
    • Asakawa, A.1    Inui, A.2    Kaga, T.3
  • 19
    • 41549110998 scopus 로고    scopus 로고
    • Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure
    • Pfluger PT, Kirchner H, Günnel S, et al. Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. Am J Physiol Gastrointest Liver Physiol 2008; 294(3): G610-8.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , Issue.3
    • Pfluger, P.T.1    Kirchner, H.2    Günnel, S.3
  • 20
    • 77957274035 scopus 로고    scopus 로고
    • Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons
    • Briggs DI, Enriori PJ, Lemus MB, Cowley MA, Andrews ZB. Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons. Endocrinology 2010, 151(10): 4745-55.
    • (2010) Endocrinology , vol.151 , Issue.10 , pp. 4745-4755
    • Briggs, D.I.1    Enriori, P.J.2    Lemus, M.B.3    Cowley, M.A.4    Andrews, Z.B.5
  • 21
    • 79951682389 scopus 로고    scopus 로고
    • Metabolic status regulates ghrelin function on energy homeostasis
    • Briggs DI, Andrews ZB. Metabolic status regulates ghrelin function on energy homeostasis. Neuroendocrinology 2011; 93(1): 48-57.
    • (2011) Neuroendocrinology , vol.93 , Issue.1 , pp. 48-57
    • Briggs, D.I.1    Andrews, Z.B.2
  • 22
    • 46049083776 scopus 로고    scopus 로고
    • The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
    • Lutter M, Sakata I, Osborne-Lawrence S, et al. The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci 2008; 11(7): 752-3.
    • (2008) Nat Neurosci , vol.11 , Issue.7 , pp. 752-753
    • Lutter, M.1    Sakata, I.2    Osborne-Lawrence, S.3
  • 23
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000; 407(6806): 908-13.
    • (2000) Nature , vol.407 , Issue.6806 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 24
    • 0036097362 scopus 로고    scopus 로고
    • Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion
    • Date Y, Nakazato M, Hashiguchi S, et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes 2002; 51(1): 124-9.
    • (2002) Diabetes , vol.51 , Issue.1 , pp. 124-129
    • Date, Y.1    Nakazato, M.2    Hashiguchi, S.3
  • 25
    • 0037098974 scopus 로고    scopus 로고
    • The ghrelin cell: A novel developmentally regulated islet cell in the human pancreas
    • Wierup N, Svensson H, Mulder H, Sundler F. The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept 2002; 107(1-3): 63-9.
    • (2002) Regul Pept , vol.107 , Issue.1-3 , pp. 63-69
    • Wierup, N.1    Svensson, H.2    Mulder, H.3    Sundler, F.4
  • 26
    • 1542267814 scopus 로고    scopus 로고
    • Ghrelin cells replace insulin-producing β cells in two mouse models of pancreas development
    • Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L. Ghrelin cells replace insulin-producing β cells in two mouse models of pancreas development. Proc Natl Acad Sci USA 2004; 101(9): 2924-9.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.9 , pp. 2924-2929
    • Prado, C.L.1    Pugh-Bernard, A.E.2    Elghazi, L.3    Sosa-Pineda, B.4    Sussel, L.5
  • 27
    • 0036959760 scopus 로고    scopus 로고
    • Expression of ghrelin and of the gh secretagogue receptor by pancreatic islet cells and related endocrine tumors
    • Volante M, AllIa E, Gugliotta P, et al. Expression of ghrelin and of the gh secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 2002; 87(3): 1300-8.
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.3 , pp. 1300-1308
    • Volante, M.1    Allia, E.2    Gugliotta, P.3
  • 28
    • 0036340074 scopus 로고    scopus 로고
    • 3+ cells are islet progenitors and are distinct from duct progenitors
    • 3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002; 129(10): 2447-57.
    • (2002) Development , vol.129 , Issue.10 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 29
    • 0037002096 scopus 로고    scopus 로고
    • Pancreatic cell lineage analyses in mice
    • Herrera P, Nepote V, Delacour A. Pancreatic cell lineage analyses in mice. Endocrine 2002; 19(3): 267-77.
    • (2002) Endocrine , vol.19 , Issue.3 , pp. 267-277
    • Herrera, P.1    Nepote, V.2    Delacour, A.3
  • 30
    • 38149098503 scopus 로고    scopus 로고
    • Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin: A study on isolated islets from mouse and rat pancreas
    • Qader SS, Hakanson R, Rehfeld JF, Lundquist I, Salehi A. Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin: a study on isolated islets from mouse and rat pancreas. Regul Pept 2008; 146(1-3): 230-7.
    • (2008) Regul Pept , vol.146 , Issue.1-3 , pp. 230-237
    • Qader, S.S.1    Hakanson, R.2    Rehfeld, J.F.3    Lundquist, I.4    Salehi, A.5
  • 31
    • 13844275996 scopus 로고    scopus 로고
    • Ghrelin activates neuronal constitutive nitric oxide synthase in pancreatic islet cells while inhibiting insulin release and stimulating glucagon release
    • Qader SS, Lundquist I, Ekelund M, Håkanson R, Salehi A. Ghrelin activates neuronal constitutive nitric oxide synthase in pancreatic islet cells while inhibiting insulin release and stimulating glucagon release. Regul Pept 2005; 128(1): 51-6.
    • (2005) Regul Pept , vol.128 , Issue.1 , pp. 51-56
    • Qader, S.S.1    Lundquist, I.2    Ekelund, M.3    Håkanson, R.4    Salehi, A.5
  • 32
    • 0036787457 scopus 로고    scopus 로고
    • The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats
    • Date Y, Murakami N, Toshinai K, et al. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 2002; 123(4): 1120-8.
    • (2002) Gastroenterology , vol.123 , Issue.4 , pp. 1120-1128
    • Date, Y.1    Murakami, N.2    Toshinai, K.3
  • 33
    • 1542270842 scopus 로고    scopus 로고
    • Effects of ghrelin on insulin and glucagon secretion: A study of isolated pancreatic islets and intact mice
    • Salehi A, Dornonville de la Cour C, Håkanson R, Lundquist I. Effects of ghrelin on insulin and glucagon secretion: a study of isolated pancreatic islets and intact mice. Regul Pept 2004; 118(3): 143-50.
    • (2004) Regul Pept , vol.118 , Issue.3 , pp. 143-150
    • Salehi, A.1    Dornonville de la Cour, C.2    Håkanson, R.3    Lundquist, I.4
  • 34
    • 33845534952 scopus 로고    scopus 로고
    • Blockade of pancreatic isletderived ghrelin enhances insulin secretion to prevent high-fat dietinduced glucose intolerance
    • Dezaki K, Sone H, Koizumi M, et al. Blockade of pancreatic isletderived ghrelin enhances insulin secretion to prevent high-fat dietinduced glucose intolerance. Diabetes 2006; 55(12): 3486-93.
    • (2006) Diabetes , vol.55 , Issue.12 , pp. 3486-3493
    • Dezaki, K.1    Sone, H.2    Koizumi, M.3
  • 35
    • 77951298589 scopus 로고    scopus 로고
    • Ghrelin inhibits insulin secretion through the AMPK-UCP2 pathway in [beta] cells
    • Wang Y, Nishi M, Doi A, et al. Ghrelin inhibits insulin secretion through the AMPK-UCP2 pathway in [beta] cells. FEBS Lett 2010; 584(8): 1503-8.
    • (2010) FEBS Lett , vol.584 , Issue.8 , pp. 1503-1508
    • Wang, Y.1    Nishi, M.2    Doi, A.3
  • 36
    • 0035875087 scopus 로고    scopus 로고
    • Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, [beta] cell dysfunction, and type 2 diabetes
    • Zhang C-Y, Baffy G, Perret P, et al. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, [beta] cell dysfunction, and type 2 diabetes. Cell 2001; 105(6): 745-55.
    • (2001) Cell , vol.105 , Issue.6 , pp. 745-755
    • Zhang, C.-Y.1    Baffy, G.2    Perret, P.3
  • 37
    • 33847319765 scopus 로고    scopus 로고
    • Diet-Induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons
    • Enriori PJ, Evans AE, Sinnayah P, et al. Diet-Induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab 2007; 5(3): 181-94.
    • (2007) Cell Metab , vol.5 , Issue.3 , pp. 181-194
    • Enriori, P.J.1    Evans, A.E.2    Sinnayah, P.3
  • 38
    • 32244439458 scopus 로고    scopus 로고
    • IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion
    • Doi A, Shono T, Nishi M, Furuta H, Sasaki H, Nanjo K. IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion. Proc Natl Acad Sci USA 2006; 103(4): 885-90.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.4 , pp. 885-890
    • Doi, A.1    Shono, T.2    Nishi, M.3    Furuta, H.4    Sasaki, H.5    Nanjo, K.6
  • 39
    • 0141453037 scopus 로고    scopus 로고
    • Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans
    • Broglio F, Gottero C, Benso A, et al. Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans. J Clin Endocrinol Metab 2003; 88(9): 4268-72.
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.9 , pp. 4268-4272
    • Broglio, F.1    Gottero, C.2    Benso, A.3
  • 40
    • 34447545671 scopus 로고    scopus 로고
    • Constant intravenous ghrelin infusion in healthy young men: Clinical pharmacokinetics and metabolic effects
    • Vestergaard ET, Hansen TK, Gormsen LC, et al. Constant intravenous ghrelin infusion in healthy young men: clinical pharmacokinetics and metabolic effects. Am J Physiol-Endocrinol Metab 2007; 292(6): E1829-36.
    • (2007) Am J Physiol-Endocrinol Metab , vol.292 , Issue.6
    • Vestergaard, E.T.1    Hansen, T.K.2    Gormsen, L.C.3
  • 41
    • 58149352421 scopus 로고    scopus 로고
    • Ghrelin infusion in humans induces acute insulin resistance and lipolysis independent of growth hormone signaling
    • Vestergaard ET, Gormsen LC, Jessen N, et al. Ghrelin infusion in humans induces acute insulin resistance and lipolysis independent of growth hormone signaling. Diabetes 2008; 57(12): 3205-10.
    • (2008) Diabetes , vol.57 , Issue.12 , pp. 3205-3210
    • Vestergaard, E.T.1    Gormsen, L.C.2    Jessen, N.3
  • 42
    • 77956357163 scopus 로고    scopus 로고
    • Ghrelin suppresses glucosestimulated insulin secretion and deteriorates glucose tolerance in healthy humans
    • Tong J, Prigeon RL, Davis HW, et al. Ghrelin suppresses glucosestimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes 2010; 59(9): 2145-51.
    • (2010) Diabetes , vol.59 , Issue.9 , pp. 2145-2151
    • Tong, J.1    Prigeon, R.L.2    Davis, H.W.3
  • 43
    • 33745834734 scopus 로고    scopus 로고
    • Ghrelin action in the brain controls adipocyte metabolism
    • Theander-Carrillo C, Wiedmer P, Cettour-Rose P, et al. Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest 2006; 116(7): 1983-93.
    • (2006) J Clin Invest , vol.116 , Issue.7 , pp. 1983-1993
    • Theander-Carrillo, C.1    Wiedmer, P.2    Cettour-Rose, P.3
  • 44
    • 66449098274 scopus 로고    scopus 로고
    • Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention
    • Davies JS, Kotokorpi P, Eccles SR, et al. Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention. Mol Endocrinol 2009; 23(6): 914-24.
    • (2009) Mol Endocrinol , vol.23 , Issue.6 , pp. 914-924
    • Davies, J.S.1    Kotokorpi, P.2    Eccles, S.R.3
  • 45
    • 0033756755 scopus 로고    scopus 로고
    • Growth hormone secretagogue binding sites in peripheral human tissues
    • Papotti M, Ghe C, Cassoni P, et al. Growth hormone secretagogue binding sites in peripheral human tissues. J Clin Endocrinol Metab 2000; 85(10): 3803-7.
    • (2000) J Clin Endocrinol Metab , vol.85 , Issue.10 , pp. 3803-3807
    • Papotti, M.1    Ghe, C.2    Cassoni, P.3
  • 46
    • 67349175270 scopus 로고    scopus 로고
    • Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes
    • Rodriguez A, Gomez-Ambrosi J, Catalan V, et al. Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. Int J Obes (Lond) 2009; 33(5): 541-52.
    • (2009) Int J Obes (Lond) , vol.33 , Issue.5 , pp. 541-552
    • Rodriguez, A.1    Gomez-Ambrosi, J.2    Catalan, V.3
  • 47
    • 22044441761 scopus 로고    scopus 로고
    • Ghrelin regulates adiposity in white adipose tissue and UCP1 mRNA expression in brown adipose tissue in mice
    • Tsubone T, Masaki T, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H. Ghrelin regulates adiposity in white adipose tissue and UCP1 mRNA expression in brown adipose tissue in mice. Regul Pept 2005; 130(1-2): 97-103.
    • (2005) Regul Pept , vol.130 , Issue.1-2 , pp. 97-103
    • Tsubone, T.1    Masaki, T.2    Katsuragi, I.3    Tanaka, K.4    Kakuma, T.5    Yoshimatsu, H.6
  • 48
    • 33644522042 scopus 로고    scopus 로고
    • Ghrelin stimulates insulin-induced glucose uptake in adipocytes
    • Patel AD, Stanley SA, Murphy KG, et al. Ghrelin stimulates insulin-induced glucose uptake in adipocytes. Regul Pept 2006; 134(1): 17-22.
    • (2006) Regul Pept , vol.134 , Issue.1 , pp. 17-22
    • Patel, A.D.1    Stanley, S.A.2    Murphy, K.G.3
  • 49
    • 1042275336 scopus 로고    scopus 로고
    • Ghrelin and desoctanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor
    • Thompson NM, Gill DAS, Davies R, et al. Ghrelin and desoctanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 2004; 145(1): 234-42.
    • (2004) Endocrinology , vol.145 , Issue.1 , pp. 234-242
    • Thompson, N.M.1    Gill, D.A.S.2    Davies, R.3
  • 50
    • 79951687006 scopus 로고    scopus 로고
    • Acute Peripheral metabolic effects of intraarterial ghrelin infusion in healthy young men
    • Vestergaard ET, Buhl M, Gjedsted J, et al. Acute Peripheral metabolic effects of intraarterial ghrelin infusion in healthy young men. J Clin Endocrinol Metab 2011; 96(2): 468-77.
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.2 , pp. 468-477
    • Vestergaard, E.T.1    Buhl, M.2    Gjedsted, J.3
  • 52
    • 0034731310 scopus 로고    scopus 로고
    • Ghrelin and desacyl ghrelin: Two major forms of rat ghrelin peptide in gastrointestinal tissue
    • Hosoda H, Kojima M, Matsuo H, Kangawa K. Ghrelin and desacyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 2000; 279(3): 909-13.
    • (2000) Biochem Biophys Res Commun , vol.279 , Issue.3 , pp. 909-913
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 54
    • 73949090944 scopus 로고    scopus 로고
    • Ontogeny of acylated ghrelin degradation in the rat
    • Ni H, Walia P, Chanoine J-P. Ontogeny of acylated ghrelin degradation in the rat. Peptides 2010; 31(2): 301-6.
    • (2010) Peptides , vol.31 , Issue.2 , pp. 301-306
    • Ni, H.1    Walia, P.2    Chanoine, J.-P.3
  • 55
    • 22344435662 scopus 로고    scopus 로고
    • Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats
    • Chen C-Y, Inui A, Asakawa A, et al. Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology 2005; 129(1): 8-25.
    • (2005) Gastroenterology , vol.129 , Issue.1 , pp. 8-25
    • Chen, C.-Y.1    Inui, A.2    Asakawa, A.3
  • 56
    • 33645857375 scopus 로고    scopus 로고
    • Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor
    • Toshinai K, Yamaguchi H, Sun Y, et al. Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology 2006; 147(5): 2306-14.
    • (2006) Endocrinology , vol.147 , Issue.5 , pp. 2306-2314
    • Toshinai, K.1    Yamaguchi, H.2    Sun, Y.3
  • 57
    • 10844287775 scopus 로고    scopus 로고
    • Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin
    • Asakawa A, Inui A, Fujimiya M, et al. Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut 2005; 54(1): 18-24.
    • (2005) Gut , vol.54 , Issue.1 , pp. 18-24
    • Asakawa, A.1    Inui, A.2    Fujimiya, M.3
  • 58
    • 0037164747 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
    • Baldanzi G, Filigheddu N, Cutrupi S, et al. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol 2002; 159(6): 1029-37.
    • (2002) J Cell Biol , vol.159 , Issue.6 , pp. 1029-1037
    • Baldanzi, G.1    Filigheddu, N.2    Cutrupi, S.3
  • 59
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Date Y, Kojima M, Hosoda H, et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000; 141(11): 4255-61.
    • (2000) Endocrinology , vol.141 , Issue.11 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3
  • 60
    • 17744396454 scopus 로고    scopus 로고
    • Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines
    • Cassoni P, Papotti M, Ghe C, et al. Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. J Clin Endocrinol Metab 2001; 86(4): 1738-45.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.4 , pp. 1738-1745
    • Cassoni, P.1    Papotti, M.2    Ghe, C.3
  • 61
    • 14044250280 scopus 로고    scopus 로고
    • Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes
    • Gauna C, Delhanty PJD, Hofland LJ, et al. Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes. J Clin Endocrinol Metab 2005; 90(2): 1055-60.
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.2 , pp. 1055-1060
    • Gauna, C.1    Delhanty, P.J.D.2    Hofland, L.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.