Changes in plasma levels of ghrelin, leptin, and other hormonal and metabolic parameters following standardized breakfast, lunch, and physical exercise before and after a multidisciplinary weight-reduction intervention in obese adolescents

Journal of Endocrinological Investigation

Volumn 33, Issue 9, 2010, Pages 633-639

  Rigamonti, A E ^a   Agosti, F ^b   De Col, A ^b   Marazzi, N ^b   Lafortuna, C L ^c   Cella, S G ^a   Muller, E E ^a   Sartorio, A ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^c INSTITUTE OF MOLECULAR BIOIMAGING AND PHYSIOLOGY   (Italy)

Author keywords

Adolescent; Ghrelin; Leptin; Obesity; Weight loss

Indexed keywords

FATTY ACID; GHRELIN; GLUCOSE; GROWTH HORMONE; INSULIN; LEPTIN; SOMATOMEDIN;

ADOLESCENT; APPETITE; ARTICLE; BEHAVIOR THERAPY; BODY COMPOSITION; CLINICAL ARTICLE; CLINICAL ASSESSMENT; EXERCISE; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HUMAN; IMPEDANCE; MALE; MEAL; OBESITY; PHYSICAL ACTIVITY; PROTEIN BLOOD LEVEL; VISUAL ANALOG SCALE; WEIGHT REDUCTION;

ADOLESCENT; CHILD; COMBINED MODALITY THERAPY; EATING; EXERCISE; FEMALE; GHRELIN; HUMANS; INTERDISCIPLINARY COMMUNICATION; LEPTIN; MALE; OBESITY; PEPTIDE HORMONES; REFERENCE STANDARDS; WEIGHT LOSS;

EID: 78651225728     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/6949     Document Type: Article

References (43)

1. Lobstein T, Baur L, Uauy R; IASO International Obesity TaskForce. Obesity in children and young people: a crisis in public health. Obes Rev 2004, 5 (Suppl 1): 4-104.
2. Wang Y, Lobstein T. Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes 2006, 1: 11-25.
3. Cali AM, Caprio S. Obesity in children and adolescents. J Clin Endocrinol Metab 2008, 93: S31-6.
4. Maffeis C, Schutz Y, Pinelli L Effect of weight loss on resting energy expenditure in obese prepubertal children. Int J Obes Relat Metab Disord 1992, 16: 41-7.
5. Sothern MS, Loftin M, Suskind RM, Udall JN Jr, Blecker U. The impact of significant weight loss on resting energy expenditure in obese youth. J Investig Med 1999, 47: 222-6.
6. Lazzer S, Vermorel M, Montaurier C, Meyer M, Boirie Y. Changes in adipocyte hormones and lipid oxidation associated with weight loss and regain in severely obese adolescents. Int J Obes (Lond) 2005, 29: 1184-91.
7. Barbeau P, Gutin B, Litaker M, Owens S, Riggs S, Okuyama T. Correlates of individual differences in bodycomposition changes resulting from physical training in obese children. Am J Clin Nutr 1999, 69: 705-11.
8. Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001, 86: 5992.
9. Wren AM, Small CJ, Abbott CR, et al. Ghrelin causes hyperphagia and obesity in rats. Diabetes 2001, 50: 2540-7.
10. De Vriese C, Delporte C. Ghrelin: a new peptide regulating growth hormone release and food intake. Int J Biochem Cell Biol 2008, 40: 1420-4.
11. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001, 50: 1714-9.
12. Cummings DE, Frayo RS, Marmonier C, Aubert R, Chapelot D. Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am J Physiol Endocrinol Metab 2004, 287: E297-304.
13. Small CJ, Bloom SR. Gut hormones and the control of appetite. Trends Endocrinol Metab 2004, 15: 259-63.
14. Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996, 382: 250-2.
15. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998, 395: 763-70.
16. Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995, 1: 1155-61.
17. Hansen TK, Dall R, Hosoda H, et al. Weight loss increases circulating levels of ghrelin in human obesity. Clin Endocrinol (Oxf) 2002, 56: 203-6.
18. de Luis DA, Sagrado MG, Conde R, Aller R, Izaola O. Changes of ghrelin and leptin in response to hypocaloric diet in obese patients. Nutrition 2008, 24: 162-6.
19. Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002, 346: 1623-30.
20. Doucet E, Cameron J. Appetite control after weight loss: what is the role of bloodborne peptides? Appl Physiol Nutr Metab 2007, 32: 523-32.
21. Cacciari E, Milani S, Balsamo A, et al. Italian cross-sectional growth charts for height, weight and BMI (6-20 y). Eur J Clin Nutr 2002, 56: 171-80.
22. Societá Italiana di Nutrizione Umana. Livelli di Assunzione Raccomandati di Energia e Nutrienti per la Popolazione ltaliana. Societé Italiana di Nutrizione Umana, 1996.
23. Reybrouck T, Weymans M, Stijns H, Knops J, van der Hauwaert L. Ventilatory anaerobic threshold in healthy children. Age and sex differences. Eur J Appl Physiol Occup Physiol 1985, 54: 278-84.
24. Flint A, Raben A, Blundell JE, Astrup A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 2000, 24: 38-48.
25. Parker BA, Sturm K, Macintosh CG, Feinle C, Horowitz M, Chapman IM. Relation between food intake and visual analogue scale ratings of appetite and other sensations in healthy older and young subjects. Eur J Clin Nutr 2004, 58: 212-8.
26. Zwiauer KF, Mueller T, Widhalm K. Resting metabolic rate in obese children before, during and after weight loss. Int J Obes Relat Metab Disord 1992, 16: 11-6.
27. Tounian P, Frelut ML, Parlier G, et al. Weight loss and changes in energy metabolism in massively obese adolescents. Int J Obes Relat Metab Disord 1999, 23: 830-7.
28. Broglio F, Prodam F, Riganti F, Muccioli G, Ghigo E. Ghrelin: from somatotrope secretion to new perspectives in the regulation of peripheral metabolic functions. Front Horm Res 2006, 35: 102-14.
29. Bellone S, Rapa A, Vivenza D, et al. Circulating ghrelin levels as function of gender, pubertal status and adiposity in childhood. J Endocrinol Invest 2002, 25: RC13-5.
30. Reinehr T, Roth CL, Alexy U, Kersting M, Kiess W, Andler W. Ghrelin levels before and after reduction of overweight due to a low-fat high-carbohydrate diet in obese children and adolescents. Int J Obes (Lond) 2005, 29: 362-8.
31. Patterson CM, Levin BE. Role of exercise in the central regulation of energy homeostasis and in the prevention of obesity. Neuroendocrinology 2008, 87: 65-70.
32. Pasman WJ, Westerterp-Plantenga MS, Saris WH. The effect of exercise training on leptin levels in obese males. Am J Physiol 1998, 274: E280-6.
33. Gutin B, Owens S. Role of exercise intervention in improving body fat distribution and risk profile in children. Am J Hum Biol 1999, 11: 237-47.
34. Sudi KM, Gallistl S, Borkenstein MH, et al. Effects of weight loss on leptin, sex hormones, and measures of adiposity in obese children. Endocrine 2001, 14: 429-35.
35. Perseghin G, Price TB, Petersen KF, et al. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med 1996, 335: 1357-62.
36. Considine RV. Invited editorial on 'acute and chronic effects of exercise on leptin levels in humans'. J Appl Physiol 1997, 83: 3-4.
37. Kyriazis GA, Caplan JD, Lowndes J, et al. Moderate exercise-induced energy expenditure does not alter leptin levels in sedentary obese men. Clin J Sport Med 2007, 17: 49-51.
38. Rasmussen MH, Hvidberg A, Juul A, et al. Massive weight loss restores 24-h growth hormone release profiles and serum insulin-like growth factor-1 levels in obese subjects. J Clin Endocrinol and Metab 1995, 80: 1407-15.
39. De Marinis L, Bianchi A, Mancini A, et al. Growth hormone secretion and leptin in morbid obesity before and after biliopancreatic diversion: relationships with insulin and body composition. J Clin Endocrinol and Metab 2004, 89: 174-80.
40. Edén Engström B, Burman P, Holdstock C, Ohrvall M, Sundbom M, Karlsson FA. Effects of gastric bypass on the GH/IGF-I axis in severe obesity - and a comparison with GH deficiency. Eur J Endocrinol 2006, 154: 53-9.
41. Rasmussen MH, Juul A, Kjems LL, Skakkebaek NE, Hilsted J. Lack of stimulation of 24-h growth hormone release by hypocaloric diet in obesity. J Clin Endocrinol and Metab 1995, 80: 796-801.
42. Grottoli S, Gauna C, Tassone F, et al. Both fasting-induced leptin reduction and GH increase are blunted in Cushing's syndrome and in simple obesity. Clin Endocrinol 2003, 58: 220-8.
43. Rasmussen MH, Juul A, Kjems LL, Hilsted J. Effects of short-term caloric restriction on circulating free IGF-I, acid-labile subunit, IGF-binding proteins (IGFBPs)-1-4, and IGFBPs-1-3 protease activity in obese subjects. Eur J Endocrinol 2006, 155: 575-81.