Hepatitis C virus-associated hypobetalipoproteinemia is correlated with plasma viral load, steatosis, and liver fibrosis

American Journal of Gastroenterology

Volumn 98, Issue 5, 2003, Pages 1150-1154

  Petit, Jean Michel ^a   Benichou, Muriel ^a   Duvillard, Laurence ^a   Jooste, Valerie ^a   Bour, Jean Baptiste ^a   Minello, Anne ^a   Verges, Bruno ^a   Brun, Jean Marcel ^a   Gambert, Philippe ^a   Hillon, Patrick ^a  

^a HÔPITAL DU BOCAGE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; APOLIPOPROTEIN B; RIBAVIRIN;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DISEASE COURSE; DRUG RESPONSE; FATTY LIVER; FEMALE; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HISTOLOGY; HUMAN; HUMAN TISSUE; HYPOBETALIPOPROTEINEMIA; LIPID BLOOD LEVEL; LIPID METABOLISM; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NONHUMAN; PRIORITY JOURNAL; VIROLOGY; VIRUS LOAD;

EID: 0037732910     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9270(03)00106-0     Document Type: Article

References (24)

1. Serfaty L, Andreani T, Giral P, et al. Hepatitis C virus induced hypobetalipoproteinemia: A possible mechanism for steatosis in chronic hepatitis C. J Hepatol 2001;34:428-34.
2. Fabris C, Federico E, Soardo G, et al. Blood lipids of patients with chronic hepatitis: Differences related to viral etiology. Clin Chem Acta 1997;261:159-61.
3. Maggi G, Bottelli R, Gola D, et al. Serum cholesterol and chronic hepatitis C. Ital J Gastroenterol 1996;28:436-40.
4. Thomssen R, Bonk S, Thiele A. Density heterogeneities of hepatitis C virus in human sera due to the binding of B-lipoproteins and immunoglobulins. Med Microbiol Immunol 1993;182:329-34.
5. Cicognani C, Malavolti M, Morselli-Labate AM, et al. Serum lipid and lipoprotein patterns in patients with liver cirrhosis and chronic active hepatitis. Arch Intern Med 1997;157:792-6.
6. Monazahian M, Bohme I, Bonk S, et al. Low density lipoprotein receptor as a candidate receptor for hepatitis C virus. J Med Virol 1999;57:223-9.
7. Agnello V, Abel G, Elfahal M, et al. Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc Natl Acad Sci USA 1999;96:12766-71.
8. Minuk GY, Weinstein S, Kaita KD. Serum cholesterol and low-density lipoprotein cholesterol levels as predictors of response to interferon therapy for chronic hepatitis C. Ann Intern Med 2000;132:761-2.
9. Toyada H, Kumada T. Cholesterol and lipoprotein levels as predictors of response to interferon for hepatitis C. Ann Intern Med 2000;133:921.
10. Soardo G, Pirisi M, Fonda M, et al. Changes in blood lipid composition and response to interferon treatment in chronic hepatitis C. J Interferon Res 1995;15:705-12.
11. D'Arienzo A, Manguso F, Scaglione G, et al. Prognostic value of progressive decrease in serum cholesterol survival in Child-Pugh C viral cirrhosis. Scand J Gastroenterol 1998;33:1213-8.
12. Allison ME, Wreghitt T, Palmer CR, et al. Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population. J Hepatol 1994;21:1135-39.
13. Caronia S, Taylor K, Pagliaro L, et al. Further evidence for an association between non-insulin-dependent diabetes mellitus and chronic hepatitis C virus infection. Hepatology 1999;30:1059-63.
14. Mehta SH, Brancati FL, Sulkowski MS, et al. Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States. Ann Intern Med 2000;133:592-9.
15. Petit JM, Bour JB, Galland-Jos C, et al. Risk factors for diabetes mellitus and early insulin resistance in chronic hepatitis C. J Hepatol 2001;35:279-83.
16. Taskinen MR. Insulin resistance and lipoprotein metabolism. Curr Opin Lipidol 1995;6:153-60.
17. Charlton M, Sreekumar R, Rasmussen D, et al. Apolipoprotein synthesis in nonalcoholic steatohepatitis. Hepatology 2002;35:898-904.
18. Ogata H, Akagi K, Baba M, et al. Fatty liver in a case with heterozygous familial hypobetalipoproteinemia. Am J Gastroenterol 1997;92:339-42.
19. Wetterau JR, Aggerbeck LP, Bouma ME, et al. Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science 1992;258:999-1001.
20. Wetterau JR, Lin MC, Jamil H. Microsomal triglyceride transfer protein. Biochim Biophys Acta 1997;1345:136-50.
21. Raabe M, Veniant MM, Sullivan MA, et al. Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knocknout mice. J Clin Invest 1999;103:1287-98.
22. Bernard S, Touzet S, Personne I, et al. Association between microsomal triglyceride transfer protein gene polymorphism and the biological features of liver steatosis in patients with type II diabetes. Diabetologia 2000;43:995-9.
23. Perlemuter G, Sabile A, Letteron P, et al. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: A model of viral-related steatosis. FASEB J 2002;16:185-94.
24. Martinot-Peignoux M, Marcellin P, Pouteau M, et al. Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alpha therapy in chronic hepatitis C. Hepatology 1995;22:1050-6.