Crystallization and liquid-liquid phase separation of monoclonal antibodies and fc-fusion proteins: Screening results

Biotechnology Progress

Volumn 27, Issue 4, 2011, Pages 1054-1067

  Trilisky, Egor ^a   Gillespie, Ronald ^a   Osslund, Timothy D ^b   Vunnum, Suresh ^a  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

Crystal; Evaporative screening; Fc fusion; IgG; Liquid liquid separation; Phase behavior; Product precipitation; Self buffering formulation

Indexed keywords

EVAPORATIVE SCREENING; FC-FUSION; IGG; LIQUID-LIQUID SEPARATION; PRODUCT PRECIPITATION; SELF-BUFFERING;

CRYSTALLIZATION; MONOCLONAL ANTIBODIES; PHASE SEPARATION; PIPE FLOW; PRECIPITATION (CHEMICAL); PROTEINS; PURIFICATION; SURFACE PLASMON RESONANCE;

LIQUIDS;

HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY;

ARTICLE; CHEMISTRY; CRYSTALLIZATION; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHODOLOGY;

ANTIBODIES, MONOCLONAL; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; RECOMBINANT FUSION PROTEINS;

EID: 79961027385     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.621     Document Type: Article

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