Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 10, 2009, Pages 2852-2855

  Hamada, Shohei ^a   Kim, Tae Dong ^b   Suzuki, Takayoshi ^a   Itoh, Yukihiro ^a   Tsumoto, Hiroki ^a   Nakagawa, Hidehiko ^a   Janknecht, Ralf ^b   Miyata, Naoki ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Histone lysine demethylase; Inhibitor; N Oxalylglycine

Indexed keywords

ENZYME INHIBITOR; GLYCINE DERIVATIVE; HISTONE METHYLTRANSFERASE; N OXALYLGLYCINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DEMETHYLATION; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; METHYLATION;

AMINO ACIDS, DICARBOXYLIC; CELL LINE; ENZYME INHIBITORS; HUMANS; NEOPLASM PROTEINS; OXIDOREDUCTASES, N-DEMETHYLATING; TRANSCRIPTION FACTORS;

EID: 65349129552     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.098     Document Type: Article

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