UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 38, 2012, Pages 15324-15329

  Wang, Chaochen ^a   Lee, Ji Eun ^a   Cho, Young Wook ^b   Xiao, Ying ^c   Jin, Qihuang ^a   Liu, Chengyu ^d   Ge, Kai ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b Korea Basic Science Institute (KBSI)   (South Korea)

^c NATIONAL CANCER INSTITUTE   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; H3K27 DEMETHYLASE UTX; HISTONE METHYLTRANSFERASE; HOX PROTEIN; NESTIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRACHYURY; TRANSCRIPTION FACTOR NANOG; TUBULIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOGENESIS; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; ENZYME ACTIVITY; FEMALE; GENE DELETION; GENE EXPRESSION; GENE LOSS; GENE TARGETING; MALE; MESODERM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METABOLISM; SIGNAL TRANSDUCTION; X CHROMOSOME; Y CHROMOSOME;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; EMBRYONIC STEM CELLS; FEMALE; FETAL PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HISTONE DEMETHYLASES; HOMEODOMAIN PROTEINS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MALE; MESODERM; MICE; MICE, KNOCKOUT; MODELS, GENETIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; T-BOX DOMAIN PROTEINS; TIME FACTORS;

MUS;

EID: 84866530722     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1204166109     Document Type: Article

References (32)

1. Keller G (2005) Embryonic stem cell differentiation: Emergence of a new era in biology and medicine. Genes Dev 19:1129-1155.
2. Wilkinson DG, Bhatt S, Herrmann BG (1990) Expression pattern of the mouse T gene and its role in mesoderm formation. Nature 343:657-659.
3. Arnold SJ, et al. (2000) Brachyury is a target gene of the Wnt/beta-catenin signaling pathway. Mech Dev 91:249-258. (Pubitemid 30125923)
4. Yamaguchi TP, Takada S, Yoshikawa Y, Wu N, McMahon AP (1999) T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev 13:3185-3190. (Pubitemid 30030440)
5. Martin BL, Kimelman D (2010) Brachyury establishes the embryonic mesodermal progenitor niche. Genes Dev 24:2778-2783.
6. Boyer LA, et al. (2006) Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441:349-353. (Pubitemid 44050199)
7. Pasini D, Bracken AP, Hansen JB, Capillo M, Helin K (2007) The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol 27:3769-3779. (Pubitemid 46726184)
8. Hong S, et al. (2007) Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc Natl Acad Sci USA 104:18439-18444. (Pubitemid 350210715)
9. Swigut T, Wysocka J (2007) H3K27 demethylases, at long last. Cell 131:29-32. (Pubitemid 47498542)
10. Agger K, et al. (2007) UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 449:731-734. (Pubitemid 47552088)
11. Lee MG, et al. (2007) Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science 318:447-450.
12. Lan F, et al. (2007) A histone H3 lysine 27 demethylase regulates animal posterior development. Nature 449:689-694. (Pubitemid 47552096)
13. Lee S, Lee JW, Lee S-K (2012) UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program. Dev Cell 22:25-37.
14. Miller SA, Mohn SE, Weinmann AS (2010) Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol Cell 40:594-605.
15. Seenundun S, et al. (2010) UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis. EMBO J 29:1401-1411.
16. Smith ER, et al. (2008) Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol 28:1041-1046. (Pubitemid 351160060)
17. Macarthur BD, Ma'ayan A, Lemischka IR (2009) Systems biology of stem cell fate and cellular reprogramming. Nat Rev Mol Cell Biol 10:672-681.
18. Williams RL, et al. (1988) Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336:684-687. (Pubitemid 19007951)
19. Walker E, et al. (2010) Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell 6:153-166.
20. Wang JK, et al. (2010) The histone demethylase UTX enables RB-dependent cell fate control. Genes Dev 24:327-332.
21. Bibel M, et al. (2004) Differentiation of mouse embryonic stem cells into a defined neuronal lineage. Nat Neurosci 7:1003-1009. (Pubitemid 39129511)
22. Keller GM (1995) In vitro differentiation of embryonic stem cells. Curr Opin Cell Biol 7:862-869.
23. Dovey OM, Foster CT, Cowley SM (2010) Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation. Proc Natl Acad Sci USA 107:8242-8247.
24. Dahle O, Kumar A, Kuehn MR (2010) Nodal signaling recruits the histone demethylase Jmjd3 to counteract polycomb-mediated repression at target genes. Sci Signal 3:ra48.
25. Herrmann BG (1991) Expression pattern of the Brachyury gene in whole-mount TWis/TWis mutant embryos. Development 113:913-917.
26. Dzierzak E, Medvinsky A (2008) The discovery of a source of adult hematopoietic cells in the embryo. Development 135:2343-2346.
27. Watanabe K, Dai X (2011) A WNTer revisit: New faces of â-catenin and TCFs in pluripotency. Sci Signal 4:pe41.
28. Cox BJ, et al. (2010) Phenotypic annotation of the mouse X chromosome. Genome Res 20:1154-1164.
29. Vandamme J, et al. (2012) The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity. PLoS Genet 8:e1002647.
30. Jin Q, et al. (2011) Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J 30:249-262.
31. Cho YW, et al. (2009) Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis. Cell Metab 10:27-39.
32. Cho Y-W, et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem 282:20395-20406. (Pubitemid 47099985)