Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons

Journal of Neuroscience

Volumn 28, Issue 17, 2008, Pages 4521-4527

  Xu, Jun ^a,b,c   Deng, Xinxian ^a   Watkins, Rebecca ^c   Disteche, Christine M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b TUFTS UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Androgen; Cognition; Estrogen; Klinefelter's syndrome; Neuron; Turner syndrome

Indexed keywords

HISTONE H3; LYSINE; METHYLTRANSFERASE; N DEMETHYLASE; NUCLEAR PROTEIN; PROTEIN; UTX PROTEIN, MOUSE; UTY PROTEIN, MOUSE;

ACETYLATION; AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTICLE; BRAIN FUNCTION; BRAIN REGION; CONTROLLED STUDY; EMBRYONAL CARCINOMA; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; LIVER FUNCTION; MALE; METHYLATION; MOUSE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEX DIFFERENCE; TETRATRICOPEPTIDE REPEAT; THALAMUS MIDLINE NUCLEUS; UBIQUITINATION; X CHROMOSOME; Y CHROMOSOME; ANIMAL; BIOSYNTHESIS; BRAIN; C57BL MOUSE; CELL CULTURE; COMPARATIVE STUDY; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; PHYSIOLOGY; SEXUAL DEVELOPMENT;

ANIMALS; BRAIN; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; MICE; MICE, INBRED C57BL; NEURONS; NUCLEAR PROTEINS; OXIDOREDUCTASES, N-DEMETHYLATING; PROTEINS; SEX CHARACTERISTICS; TUMOR CELLS, CULTURED;

EID: 43749094750     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5382-07.2008     Document Type: Article

References (38)

1. Adolphs R (2003) Cognitive neuroscience of human social behaviour. Nat Rev Neurosci 3:165-178.
2. Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K (2007) UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 449:731-734.
3. Anderson AK, Phelps EA (2000) Expression without recognition: contributions of the human amygdala to emotional communication. Psychol Sci 11:106-111.
4. Arnold AP (2004) Sex chromosomes and brain gender. Nat Rev Neurosci 5:701-708.
5. Arnold AP, Gorski RA (1984) Gonadal steroid induction of structural sex differences in the central nervous system. Annu Rev Neurosci 7:413-442.
6. Arnold AP, Xu J, Grisham W, Chen X, Kim YH, Itoh Y (2004) Sex chromosomes and brain sexual differentiation. Endocrinology 145:1057-1062.
7. Becker JB, Arnold AP, Berkley KJ, Blaustein JD, Eckel LA, Hampson E, Herman JP, Marts S, Sadee W, Steiner M, Taylor J, Young E (2005) Strategies and methods for research on sex differences in brain and behavior. Endocrinology 146:1650-1673.
8. Brown CJ, Greally JM (2003) A stain upon the silence: genes escaping X inactivation. Trends Genet 19:432-438.
9. Byrnes EM, Lee JO, Bridges RS (2007) Alterations in GABAA receptor alpha2 subunit mRNA expression following reproductive experience in rats. Neuroendocrinology 85:148-156.
10. Carrel L, Willard HF (2005) X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 434:400-404.
11. Disteche CM, Filippova GN, Tsuchiya KD (2002) Escape from X inactivation. Cytogenet Genome Res 99:36-43.
12. Gatewood JD, Wills A, Shetty S, Xu J, Arnold AP, Burgoyne PS, Rissman EF (2006) Sex chromosomes complement and gonadal sex influence aggressive and parental behaviors in mice. J Neurosci 26:2335-2342.
13. Good CD, Lawrence K, Thomas NS, Price CJ, Ashburner J, Friston KJ, Frackowiak RS, Oreland L, Skuse DH (2003) Dosage-sensitive X-linked locus influences the development of amygdale and orbitofrontal cortex, and fear recognition in humans. Brain 126:2431-2446.
14. Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P (1998) The UTX gene escapes X inactivation in mice and humans. Hum Mol Genet 7:737-742.
15. Heard E, Disteche CM (2006) Dosage compensation in mammals: fine-tuning the expression of the X chromosome. Genes Dev 20:1848-1867.
16. Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K (2007) Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc Natl Acad Sci USA 104:18439-18444.
17. Kesler SR, Garrett A, Bender B, Yankowitz J, Zeng SM, Reiss AL (2004) Amygdala and hippocampal volumes in Turner syndrome: a high-resolution MRI study of X-monosomy. Neuropsychologia 42:1971-1978.
18. Klose RJ, Zhang Y (2007) Regulation of histone methylation by demethylimination and demethylation. Nat Rev Mol Cell Biol 8:307-318.
19. Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y (2007) A histone H3lysine 27 demethylase regulates animal posterior development. Nature 449:689-694.
20. Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinbert D, Di Croce L, Shiekhattar R (2007) Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science 318:447-450.
21. Lovell-Badge R, Robertson E (1990) XY female mice resulting from a heritable mutation in the primary testis-determining gene, Tdy. Development 109:635-646.
22. Lyon MF (1961) Gene action in the X-chromosome of the mouse (Mus musculus L). Nature 190:372-373.
23. McBurney MW (1993) p19 embryonal carcinoma cells. Int J Deve Biol 37:135-140.
24. Morris JA, Jordan CL, Breedlove SM (2004) Sexual differentiation of the vertebrate nervous system. Nat Neurosci 7:1034-1039.
25. Morris JS, Frith CD, Perrett DI, Rowland D, Young AW, Calder AJ, Dolan RJ (1996) A differential neural response in the human amygdale to fearful and happy facial expressions. Nature 383:812-815.
26. Nelson RJ, Trainor BC (2007) Neural mechanisms of aggression. Nat Rev Neurosci 8:536-546.
27. Nguyen DK, Disteche CM (2006) Dosage compensation of the active X chromosome in mammals. Nat Genet 38:47-53.
28. Palaszynski KM, Smith DL, Kamrava S, Burgoyne PS, Arnold AP, Voskuhl RR (2005) A yin-yang effect between sex chromosome complement and sex hormones on the immune response. Endocrinology 146:3280-3285.
29. Ross J, Zinn A, McCauley E (2000) Neurodevelopmental and psychosocial aspects of Turner syndrome. Ment Retard Dev Disabil Res Rev 6:135-141.
30. Skuse D, Morris J, Lawrence K (2003) The amygdale and development of the social brain. Ann NY Acad Sci 1008:91-101.
31. Skuse DH, James RS, Bishop DV, Coppin B, Dalon P, Aamodt-Leeper G, Bacarese-Hamilton M, Creswell C, McGurk R, Jacobs PA (1997) Evidence from Turner's syndrome of an imprinted X-linked locus affecting cognitive function. Nature 387:705-708.
32. Tsankova N, Renthal W, Kumar A, Nestler EJ (2007) Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci 8:355-367.
33. Weiss LA, Purcell S, Waggoner S, Lawrence K, Spektor D, Daly MJ, Sklar P, Skuse D (2007) Identification of EFHC2 as a quantitative trait locus for fear recognition in Turner syndrome. Hum Mol Genet 16:107-113.
34. Xu J, Disteche CM (2006) Sex differences in brain expression of X- and Y-linked genes. Brain Res 1126:50-55.
35. Xu J, Burgoyne PS, Arnold AP (2002) Sex differences in sex chromosome gene expression in mouse brain. Hum Mol Genet 11:1409-1419.
36. Xu J, Taya S, Kaibuchi K, Arnold AP (2005) Sexually dimorphic expression of Usp9x is related to sex chromosome complement in adult mouse brain. Eur J Neuro 21:3017-3022.
37. Xu J, Watkins R, Arnold AP (2006) Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain. Gene Expr Patterns 6:146-155.
38. Zechner U, Wilda M, Kehrer-Sawatzki H, Vogel W, Fundele R, Hameister H (2001) A high density of X-linked genes for general cognitive ability: a run-away process shaping human evolution? Trends Genet 17:697-701.