Injectable long-term control-released in situ gels of hydrochloric thiothixene for the treatment of schizophrenia: Preparation, in vitro and in vivo evaluation

International Journal of Pharmaceutics

Volumn 469, Issue 1, 2014, Pages 23-30

  Xin, Che ^a   Lihong, Wang ^a   Qiuyuan, Li ^a   Hongzhuo, Liu ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Biodegradable; Control released; Hydrochloric thiothixene; In situ gel; Injectable; PLA; Schizophrenia

Indexed keywords

BENZYL BENZOATE; HYDROCHLORIC THIOTHIXENE; POLYLACTIC ACID; TIOTIXENE; UNCLASSIFIED DRUG; BENZOIC ACID DERIVATIVE; DELAYED RELEASE FORMULATION; DRUG CARRIER; GEL; LACTIC ACID; NEUROLEPTIC AGENT; POLYMER;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; HISTOCOMPATIBILITY; IN VITRO STUDY; IN VIVO STUDY; LONG TERM CARE; MALE; MAXIMUM PLASMA CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PRODUCT PARAMETERS; RAT; SCHIZOPHRENIA; ANIMAL; BLOOD; CHEMISTRY; DELAYED RELEASE FORMULATION; GEL; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; PHARMACEUTICS; PROCEDURES; SOLUBILITY; WISTAR RAT;

ANIMALS; ANTIPSYCHOTIC AGENTS; BENZOATES; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; GELS; HUMANS; INJECTIONS, INTRAMUSCULAR; LACTIC ACID; MALE; POLYMERS; RATS, WISTAR; SCHIZOPHRENIA; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; THIOTHIXENE;

EID: 84899800519     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.04.044     Document Type: Article

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