Injectable implants for the sustained release of protein and peptide drugs

Drug Discovery Today

Volumn 18, Issue 7-8, 2013, Pages 337-349

  Agarwal, Priyanka ^a   Rupenthal, Ilva D ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; BLEOMYCIN A5; BOVINE SERUM ALBUMIN; BUPIVACAINE; CYCLOSPORIN A; CYTORYN; DOXIROBE; DOXYCYCLINE HYCLATE; ENZYME; ETHINYLESTRADIOL; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; GROWTH FACTOR; HORSERADISH PEROXIDASE; HUMAN GROWTH HORMONE; INSULIN; INTERLEUKIN 2; LEUPRORELIN; LYSOZYME; ONCOGEL; PACLIGEL; PACLITAXEL; PEPTIDE; PLASMID DNA; POLYMER; POSIDUR; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RELDAY; REPAGLINIDE; RISPERIDONE; RIVASTIGMINE; ROSIGLITAZONE; TISSUE PLASMINOGEN ACTIVATOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

CLINICAL TRIAL; CROSS LINKING; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG RELEASE; GEL; HUMAN; IMPLANT; LIQUID; MACROMOLECULE; MEDICAL DEVICE; PERIODONTITIS; PH; PRECIPITATION; REVIEW; THERMAL ANALYSIS;

ANIMALS; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; HUMANS; INJECTIONS; PEPTIDES; PROTEINS;

EID: 84875737923     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2013.01.013     Document Type: Review

References (154)

1. R. Pawar Protein and peptide parenteral controlled delivery Expert Opin. Biol. Ther. 4 2004 1203 1212 (Pubitemid 39005728)
2. J.L. Cleland Emerging protein drug delivery methods Curr. Opin. Biotechnol. 12 2001 212 219 (Pubitemid 32247411)
3. J. Shaji, and V. Patole Protein and peptide drug delivery: oral approaches Indian J. Pharm. Sci. 70 2008 269 277
4. V.H.L. Lee Enzymatic barriers to peptide and protein absorption Crit. Rev. Ther. Drug Carrier Syst. 5 1988 69 97
5. M. Bi, and J. Singh Degradation of luteinizing hormone releasing hormone in buccal, liver, nasal and skin tissues Int. J. Pharm. 175 1998 269 273 (Pubitemid 28517983)
6. C.G. Pitt The controlled parenteral delivery of polypeptides and proteins Int. J. Pharm. 59 1990 173 196 (Pubitemid 20146149)
7. L.C. Collins-Gold Parenteral emulsions for drug delivery Adv. Drug Deliv. Rev. 5 1990 189 208 (Pubitemid 20333024)
8. A. Hatefi, and B. Amsden Biodegradable injectable in situ forming drug delivery systems J. Control. Release 80 2002 9 28 (Pubitemid 34273745)
9. G.L. Yewey Delivery of proteins from a controlled release injectable implant Pharm. Biotechnol. 10 1997 93 117
10. K. Al-Tahami, and J. Singh Smart polymer based delivery systems for peptides and proteins Recent Pat. Drug Deliv. Form. 1 2007 65 71
11. M. Madhu Biodegradable injectable implant systems for sustained delivery using poly (lactide-co-glycolide) copolymers Int. J. Pharm. Pharm. Sci. 1 Suppl. 1 2009 103 107
12. R.E. Eliaz, and J. Kost Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins J. Biomed. Mater. Res. A 50 2000 388 396 (Pubitemid 30180731)
13. D.L. Elbert Protein delivery from materials formed by self-selective conjugate addition reactions J. Control. Release 76 2001 11 25 (Pubitemid 32786881)
14. S.A. Charman Techniques for assessing the effects of pharmaceutical excipients on the aggregation of porcine growth hormone Pharm. Res. 10 1993 954 962 (Pubitemid 23211415)
15. S. Li Inhibitory effect of sugars and polyols on the metal-catalyzed oxidation of human relaxin J. Pharm. Sci. 85 1996 868 872 (Pubitemid 26269484)
16. A.J. Tipton Release of naproxen from a biodegradable, injectable delivery system J. Kopecek, 19th International Symposium on Controlled Release of Bioactive Materials (Vol. 19) 1992 Controlled Release Society 314 pp.
17. R.L. Dunn A biodegrdable in situ forming drug delivery system 465 pp. I.W. Kellaway, 18th International Symposium on Controlled Release of Bioactive Materials (Vol. 18) 1991 Controlled Release Society
18. R. Astaneh Changes in morphology of in situ forming PLGA implant prepared by different polymer molecular weight and its effect on release behavior J. Pharm. Sci. 98 2009 135 145
19. W.J. Lambert, and K.D. Peck Development of an in situ forming biodegradable poly-lactide-coglycolide system for the controlled release of proteins J. Control. Release 33 1995 189 195
20. D.M. Dhanaraju Characterization of polymeric poly(ε-caprolactone) injectable implant delivery system for the controlled delivery of contraceptive steroids J. Biomed. Mater. Res. A 76 2006 63 72
21. A.J. Tipton A biodegradable injectabledeliverysystem for nonsteroidal anti-inflammatory drugs Pharm. Res. 8 1991 S S196
22. S.A. Yehia Biodegradable donepezil lipospheres for depot injection: optimization and in-vivo evaluation J. Pharm. Pharmacol. 64 2012 1425 1437
23. Y. Tang, and J. Singh Biodegradable and biocompatible thermosensitive polymer based injectable implant for controlled release of protein Int. J. Pharm. 365 2009 34 43
24. E. Ruel-Gariépy, and J-C. Leroux In situ-forming hydrogels: from in-situ review of temperature-sensitive systems Eur. J. Pharm. Biopharm. 58 2004 409 426 (Pubitemid 39037244)
25. R. Eliaz Delivery of soluble tumor necrosis factor receptor forming PLGA implants: in-vivo Pharm. Res. 17 2000 1546 1550 (Pubitemid 32217565)
26. K. Schoenhammer Biocompatibility of an injectable in situ forming depot for peptide delivery J. Pharm. Sci. 99 2010 4390 4399
27. S. Jacobs Characterization and evaluation of β-glucan formulations as injectable implants for protein and peptide delivery Drug Dev. Ind. Pharm. 38 2012 1337 1343
28. N.H. Shah A biodegradable injectable implant for delivering micro and macromolecules using poly (lactic-co-glycolic) acid (PLGA) copolymers J. Control. Release 27 1993 139 147 (Pubitemid 23328982)
29. S.A. Yehia A novel injectable in situ forming poly-dl-lactide and dl-lactide/glycolide implant containing lipospheres for controlled drug delivery J. Lipos. Res. 22 2012 128 138
30. H. Liu, and S.S. Venkatraman Cosolvent effects on the drug release and depot swelling in injectable in situ depot-forming systems J. Pharm. Sci. 101 2012 1783 1793
31. S. Dhawan Development and evaluation of in situ gel-forming system for sustained delivery of insulin J. Biomater. Appl. 25 2011 699 720
32. K.J. Brodbeck Phase inversion dynamics of PLGA solutions related to drug delivery: Part II. The role of solution thermodynamics and bath-side mass transfer J. Control. Release 62 1999 333 344 (Pubitemid 29476581)
33. P.D. Graham Phase inversion dynamics of PLGA solutions related to drug delivery J. Control. Release 58 1999 233 245 (Pubitemid 29112894)
34. C. Bouissou The influence of surfactant on PLGA microsphere glass transition and water sorption: remodeling the surface morphology to attenuate the burst release Pharm. Res. 23 2006 1295 1305 (Pubitemid 43946151)
35. R. De Souza Biocompatibility of injectable chitosan-phospholipid implant systems Biomaterials 30 2009 3818 3824
36. A. Gutowska Injectable gels for tissue engineering Anat. Rec. 263 2001 342 349 (Pubitemid 32730261)
37. N. Bhattarai Chitosan-based hydrogels for controlled, localized drug delivery Adv. Drug Deliv. Rev. 62 2010 83 99
38. S.S. Vaghani, and M.M. Patel Hydrogels based on interpenetrating network of chitosan and polyvinyl pyrrolidone for pH-sensitive delivery of repaglinide Curr. Drug Discov. Technol. 8 2011 126 135
39. Y-L. Chiu pH-triggered injectable hydrogels prepared from aqueous N-palmitoyl chitosan: in vitro characteristics and in vivo biocompatibility Biomaterials 30 2009 4877 4888
40. J. Wu A thermo- and pH-sensitive hydrogel composed of quaternized chitosan/glycerophosphate Int. J. Pharm. 315 2006 1 11 (Pubitemid 43674112)
41. J. Sun Thermosensitive chitosan hydrogel for implantable drug delivery: blending PVA to mitigate body response and promote bioavailability J. Appl. Polym. Sci. 125 2012 2092 2101
42. Y.B. Schuetz A novel thermoresponsive hydrogel based on chitosan Eur. J. Pharm. Biopharm. 68 2008 19 25 (Pubitemid 350181419)
43. A. Bochot Liposomes dispersed within a thermosensitive gel: a new dosage form for ocular delivery of oligonucleotides Pharm. Res. 15 1998 1364 1369 (Pubitemid 28427922)
44. K.M. Wasan Poloxamer 407-mediated alterations in the activities of enzymes regulating lipid metabolism in rats J. Pharm. Pharm. Sci. 6 2003 189 197 (Pubitemid 37211712)
45. A. Rey-Rico Osteogenic efficiency of in situ gelling poloxamine systems with and without bone morphogenetic protein-2 Eur. Cell. Mater. 21 2011 317 340
46. B. Jeong Thermogelling biodegradable polymers with hydrophilic backbones: PEG-g-PLGA Macromolecules 33 2000 8317 8322 (Pubitemid 32031177)
47. T. Vermonden Macromolecular diffusion in self-assembling biodegradable thermosensitive hydrogels Macromolecules 43 2010 782 789
48. S.W. Choi Thermoreversible gelation of poly(ethylene oxide) biodegradable polyester block copolymers. II J. Polym. Sci. 37 1999 2207 2218
49. B. Jeong Thermoreversible gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions Macromolecules 32 1999 7064 7069 (Pubitemid 32079730)
50. B. Jeong New biodegradable polymers for injectable drug delivery systems J. Control. Release 62 1999 109 114 (Pubitemid 29486489)
51. Y. Jeong Enzymatically degradable temperature-sensitive polypeptide as a new in-situ gelling biomaterial J. Control. Release 137 2009 25 30
52. Y.M. Kang A biodegradable, injectable, gel system based on MPEG-b-(PCL-ran-PLLA) diblock copolymers with an adjustable therapeutic window Biomaterials 31 2010 2453 2460
53. W. Xun Peptide-functionalized thermo-sensitive hydrogels for sustained drug delivery Macromol. Biosci. 9 2009 1219 1226
54. E. Ruel-Gariépy A thermosensitive chitosan-based hydrogel for the local delivery of paclitaxel Eur. J. Pharm. Biopharm. 57 2004 53 63 (Pubitemid 38058803)
55. A. Chenite Novel injectable neutral solutions of chitosan form biodegradable gels in situ Biomaterials 21 2000 2155 2161 (Pubitemid 30612386)
56. E. Renbutsu Preparation and biocompatibility of novel UV-curable chitosan derivatives Biomacromolecules 6 2005 2385 2388 (Pubitemid 41388247)
57. R. Jin Enzymatically-crosslinked injectable hydrogels based on biomimetic dextran-hyaluronic acid conjugates for cartilage tissue engineering Biomaterials 31 2010 3103 3113
58. M.J. Moura In situ forming chitosan hydrogels prepared via ionic/covalent co-cross-linking Biomacromolecules 12 2011 3275 3284
59. K.A. Davis Photoinitiated crosslinked degradable copolymer networks for tissue engineering applications Biomaterials 24 2003 2485 2495 (Pubitemid 36407665)
60. Hubbell, J.A. et al. Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers. Boards of Regents, The University of Texas System. 6,306,922
61. J.L. West, and J.A. Hubbell Photopolymerized hydrogel materials for drug delivery applications React. Polym. 25 1995 139 147
62. K.A. Smeds Photocrosslinkable polysaccharides for in situ hydrogel formation J. Biomed. Mater. Res. 55 2001 254 255
63. Y.D. Park Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks Biomaterials 24 2003 893 900 (Pubitemid 36024167)
64. K. Ono Experimental evaluation of photocrosslinkable chitosan as a biologic adhesive with surgical applications Surgery 130 2001 844 850 (Pubitemid 33022392)
65. K. Obara Controlled release of paclitaxel from photocrosslinked chitosan hydrogels and its subsequent effect on subcutaneous tumor growth in mice J. Control. Release 110 2005 79 89 (Pubitemid 41713933)
66. M. Ishihara Chitosan hydrogel as a drug delivery carrier to control angiogenesis J. Artif. Organs 9 2006 8 16
67. P.B. Malafaya Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications Adv. Drug Deliv. Rev. 59 2007 207 233 (Pubitemid 46879967)
68. H. Cui, and P.B. Messersmith Thermally triggered gelation of alginate for controlled release ACS Symp. Ser. 709 1998 203 211 (Pubitemid 128432700)
69. Y. Hori Modular injectable matrices based on alginate solution/microsphere mixtures that gel in situ and co-deliver immunomodulatory factors Acta Biomater. 5 2009 969 982
70. L. Lu Rapidly in situ forming biodegradable hydrogels by combining alginate and hydroxyapatite nanocrystal Sci. China Technol. Sci. 53 2010 272 277
71. L. Pescosolido Injectable and in situ gelling hydrogels for modified protein release Eur. Biophys. J. 39 2010 903 909
72. Y. Suzuki Evaluation of a novel alginate gel dressing: cytotoxicity to fibroblasts in vitro and foreign-body reaction in pig skin in vivo J. Biomed. Mater. Res. 39 1998 317 322 (Pubitemid 28060366)
73. L. Pescosolido Biodegradable IPNs based on oxidized alginate and dextran-HEMA for controlled release of proteins Carbohydr. Polym. 86 2011 208 213
74. T. Nakai Injectable hydrogel for sustained protein release by salt-induced association of hyaluronic acid nanogel Macromol. Biosci. 12 2012 475 483
75. T.C. Laurent The Chemistry, Biology and Medical Applications of Hyaluronan and Its Derivatives 1998 Portland Press
76. T.C. Laurent, and J.R.E. Fraser Hyaluronan FASEB J. 6 1992 2397 2404
77. N.E. Davis Modular enzymatically crosslinked protein polymer hydrogels for in situ gelation Biomaterials 31 2010 7288 7297
78. Y. Ogushi Synthesis of enzymatically-gellable carboxymethylcellulose for biomedical applications J. Biosci. Bioeng. 104 2007 30 33 (Pubitemid 47223815)
79. S.J. Sofia Peroxidase-catalyzed crosslinking of functionalized polyaspartic acid polymers J. Macromol. Sci. A 39 2002 1151 1181 (Pubitemid 35444351)
80. N.Q. Tran Supramolecular hydrogels exhibiting fast in situ gel forming and adjustable degradation properties Biomacromolecules 11 2010 617 625
81. R. Jin Enzyme-mediated fast in situ formation of hydrogels from dextran-tyramine conjugates Biomaterials 28 2007 2791 2800 (Pubitemid 46482659)
82. K.S. Kim Injectable hyaluronic acid-tyramine hydrogels for the treatment of rheumatoid arthritis Acta Biomater. 7 2011 666 674
83. F. Lee An injectable enzymatically crosslinked hyaluronic acid-tyramine hydrogel system with independent tuning of mechanical strength and gelation rate Soft Mater. 4 2008 880 887 (Pubitemid 351434096)
84. R. Jin Chondrogenesis in injectable enzymatically crosslinked heparin/dextran hydrogels J. Control. Release 152 2011 186 195
85. D. Chitkara Biodegradable injectable in situ depot-forming drug delivery systems Macromol. Biosci. 6 2006 977 990 (Pubitemid 46032935)
86. P.C. Painter, and M.M. Coleman Fundamentals of Polymer Science 1997 Technomic
87. J. Heller Polyanhydrides and poly(ortho esters) Adv. Drug Deliv. Rev. 54 2002 887 888
88. Bezwada, R.S. et al. Liquid absorbable copolymers for parenteral applications. Ethicon, Inc. 5,631,015
89. S. Einmahl A viscous bioerodible poly(ortho ester) as a new biomaterial for intraocular application J. Biomed. Mater. Res. 50 2000 566 573 (Pubitemid 30225383)
90. C.G. Pitt Poly-ε-caprolactone and its copolymers M. Chasin, R. Langer, Biodegradable Polymers as Drug Delivery Systems 1990 Marcel Dekker 71 120
91. S.B. Rizwan Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins Expert Opin. Drug Deliv. 7 2010 1133 1144
92. J.C. Shah Cubic phase gels as drug delivery systems Adv. Drug Deliv. Rev. 47 2001 229 250 (Pubitemid 32324116)
93. L. Appel An in vitro model to mimic in vivo subcutaneous monoolein degradation Pharm. Res. 11 1994 S217
94. B. Ericsson Cubic phases as delivery systems for peptide drugs Polymeric Drugs and Drug Delivery Systems Vol. 469 1991 American Chemical Society pp. 251-265
95. Z. Gao Controlled release of contraceptive steroids from biodegradable and injectable gel formulations: in vivo evaluation Pharm. Res. 12 1995 864 868
96. W-K. Fong Stimuli responsive liquid crystals provide 'on-demand' drug delivery in vitro and in vivo J. Control. Release 135 2009 218 226
97. Y-D. Dong Bulk and dispersed aqueous phase behavior of phytantriol: effect of vitamin e acetate and F127 polymer on liquid crystal nanostructure Langmuir 22 2006 9512 9518 (Pubitemid 44826357)
98. L. Lopes Reverse hexagonal phase nanodispersion of monoolein and oleic acid for topical delivery of peptides: in vitro and in vivo skin penetration of cyclosporin A Pharm. Res. 23 2006 1332 1342 (Pubitemid 43946155)
99. W-K. Fong Plasmonic nanorods provide reversible control over nanostructure of self-assembled drug delivery materials Langmuir 26 2010 6136 6139
100. S. Shikanov Intratumoral delivery of paclitaxel for treatment of orthotopic prostate cancer J. Pharm. Sci. 98 2009 1005 1014
101. M.Y. Krasko Gentamicin extended release from an injectable polymeric implant J. Control. Release 117 2007 90 96 (Pubitemid 46172499)
102. R. Censi In-situ forming hydrogels by simultaneous thermal gelling and Michael addition reaction between methacrylate bearing thermosensitive triblock copolymers and thiolated hyaluronan J. Control. Release 148 2010 e28 e29
103. W.S. Shim Novel Injectable pH and temperature sensitive block copolymer hydrogel Biomacromolecules 6 2005 2930 2934 (Pubitemid 41764046)
104. R.A. Jain Controlled delivery of drugs from a novel injectable in situ formed biodegradable PLGA microsphere system J. Microencapsul. 17 2000 343 362 (Pubitemid 30235007)
105. H. Lee, and T.G. Park Photo-crosslinkable, biomimetic, and thermo-sensitive pluronic grafted hyaluronic acid copolymers for injectable delivery of chondrocytes J. Biomed. Mater. Res. A 88 2009 797 806
106. R. Censi Photopolymerized thermosensitive hydrogels for tailorable diffusion-controlled protein delivery J. Control. Release 140 2009 230 236
107. C. Hiemstra Protein release from injectable stereocomplexed hydrogels based on PEG-PDLA and PEG-PLLA star block copolymers J. Control. Release 116 2006 e19 e21
108. C. Hiemstra Rapidly in situ forming biodegradable robust hydrogels by combining stereocomplexation and photopolymerization J. Am. Chem. Soc. 129 2007 9918 9926 (Pubitemid 47257778)
109. S. Fredenberg The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems: a review Int. J. Pharm. 415 2011 34 52
110. J. Heller Controlled release of biologically active compounds from bioerodible polymers Biomaterials 1 1980 51 57 (Pubitemid 10061159)
111. D. Klose How porosity and size affect the drug release mechanisms from PLGA-based microparticles Int. J. Pharm. 314 2006 198 206
112. A.M. Polson Periodontal pocket treatment in beagle dogs using subgingival doxycycline from a biodegradable system. I. Initial clinical responses J. Periodontol. 67 1996 1176 1184 (Pubitemid 26413009)
113. A.M. Polson Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. I. Study design, procedures, and management J. Periodontol. 68 1997 110 118 (Pubitemid 27149464)
114. ® technology in the treatment of periodontal disease Expert Opin. Investig. Drugs 7 1998 1483 1491 (Pubitemid 28408809)
115. F.M. Chu A clinical study of 22.5 mg. La-2550: a new subcutaneous depot delivery system for leuprolide acetate for the treatment of prostate cancer J. Urol. 168 2002 1199 1203
116. U.W. Tunn A 6-month depot formulation of leuprolide acetate is safe and effective in daily clinical practice: a non-interventional prospective study in 1273 patients BMC Urol. 11 2011
117. Durect The SABER™ Delivery System 2012 Durect
118. F.W. Okumu Sustained delivery of human growth hormone from a novel gel system: SABER™ Biomaterials 23 2002 4353 4358
119. Y-S. Rhee A review on the current status of long-acting injectables, including commercially marketed products Pharm. Technol. 2010 s6 s13
120. G.M. Zentner Biodegradable block copolymers for delivery of proteins and water-insoluble drugs J. Control. Release 72 2001 203 215 (Pubitemid 32522358)
121. W.E. Samlowski ReGel(R) polymer-based delivery of interleukin-2 as a cancer treatment J. Immunother. 29 2006 524 535 (Pubitemid 44395277)
122. Rathi, R. et al. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties. MacroMed, Inc. 6,201,072
123. S.J. Vukelja Phase 1 study of escalating-dose OncoGel(R) (ReGel(R)/paclitaxel) depot injection, a controlled-release formulation of paclitaxel, for local management of superficial solid tumor lesions Anticancer. Drugs 18 2007 283 289 (Pubitemid 46192981)
124. G. Aaron DuVall Phase 2: a dose-escalation study of OncoGel (ReGel/paclitaxel), a controlled-release formulation of paclitaxel, as adjunctive local therapy to external-beam radiation in patients with inoperable esophageal cancer Anticancer. Drugs 20 2009 89 95
125. InGell Injectable Gells that Deliver 2012 InGell
126. Z. Zhang Biodegradable and thermoreversible PCLA-PEG-PCLA hydrogel as a barrier for prevention of post-operative adhesion Biomaterials 32 2011 4725 4736
127. BusinessWire BioSyntech Inc.: A Novel Non-Toxic Sustained Release Taxol Formulation for Cancer Chemotherapy 2002 The Free Library
128. M. Berrada A novel non-toxic camptothecin formulation for cancer chemotherapy Biomaterials 26 2005 2115 2120 (Pubitemid 39575354)
129. S.J. De Jong Physically crosslinked dextran hydrogels by stereocomplex formation of lactic acid oligomers: degradation and protein release behavior J. Control. Release 71 2001 261 275 (Pubitemid 32276046)
130. G.W. Bos OctoDEX™-controlled release of pharmaceutical proteins from hydrogels Pharmatech May 2003
131. T. Vermonden Hydrogels for protein delivery Chem. Rev. 112 2012 2853 2888
132. G.W. Bos In situ crosslinked biodegradable hydrogels loaded with IL-2 are effective tools for local IL-2 therapy Eur. J. Pharm. Sci. 21 2004 561 567 (Pubitemid 38283931)
133. C. Manoharan, and J. Singh Evaluation of polyanhydride microspheres for basal insulin delivery: effect of copolymer composition and zinc salt on encapsulation, in vitro release, stability, in vivo absorption and bioactivity in diabetic rats J. Pharm. Sci. 98 2009 4237 4250
134. M-R. Park Sustained delivery of human growth hormone using a polyelectrolyte complex-loaded thermosensitive polyphosphazene hydrogel J. Control. Release 147 2010 359 367
135. S. Kempe Non-invasive in vivo evaluation of in situ forming PLGA implants by benchtop magnetic resonance imaging (BT-MRI) and EPR spectroscopy Eur. J. Pharm. Biopharm. 74 2010 102 108
136. K. Mäder Non-invasive in vivo characterization of release processes in biodegradable polymers by low-frequency electron paramagnetic resonance spectroscopy Biomaterials 17 1996 457 461 (Pubitemid 26047499)
137. J. Kang Stability of proteins encapsulated in injectable and biodegradable poly(lactide-co-glycolide)-glucose millicylinders Int. J. Pharm. 357 2008 235 243
138. K.Y. Cho In situ micro-sized gel-forming injectable implant using biodegradable amphiphilic graft copolymer Macromol. Biosci. 7 2007 784 788 (Pubitemid 47237505)
139. O. Jeon Controlled and sustained gene delivery from injectable, porous PLGA scaffolds J. Biomed. Mater. Res. A 98 2011 72 79
140. G. Tae Sustained release of human growth hormone from in situ forming hydrogels using self-assembly of fluoroalkyl-ended poly(ethylene glycol) Biomaterials 26 2005 5259 5266 (Pubitemid 40387848)
141. S. Lü An injectable oxidized carboxymethylcellulose/N-succinyl- chitosan hydrogel system for protein delivery Chem. Eng. J. 160 2010 779 787
142. J. Lee Injectable gel: poly(ethylene glycol)-sebacic acid polyester Polymer 47 2006 3760 3766 (Pubitemid 43767387)
143. G. Ma Thermosensitive PCL-PEG-PCL hydrogels: synthesis, characterization, and delivery of proteins J. Appl. Polym. Sci. 116 2010 1985 1993
144. M. Ishihara Controlled release of fibroblast growth factors and heparin from photocrosslinked chitosan hydrogels and subsequent effect on in vivo vascularization J. Biomed. Mater. Res. A 64 2003 551 559 (Pubitemid 37522496)
145. F. Lee An injectable hyaluronic acid-tyramine hydrogel system for protein delivery J. Control. Release 134 2009 186 193
146. Z. Gao Controlled release of contraceptive steroids from biodegradable and injectable gel formulations: in-vivo evaluations Pharma. Res. 12 1998 864 868
147. A. Vintiloiu In situ-forming oleogel implant for rivastigmine delivery Pharm. Res. 25 2008 845 852 (Pubitemid 351661832)
148. Z. Gao Study of a pingyangmycin delivery system: Zein/Zein-SAIB in situ gels Int. J. Pharm. 328 2007 57 64 (Pubitemid 44827558)
149. Y. Lu In vivo evaluation of risperidone-SAIB in situ system as a sustained release delivery system in rats Eur. J. Pharm. Biopharm. 68 2008 422 429
150. Y. Lu Sucrose acetate isobutyrate as an In situ forming system for sustained risperidone release J. Pharm. Sci. 96 2007 3252 3262
151. Y.J. Kim Controlled release of insulin from injectable biodegradable triblock copolymer Pharm. Res. 18 2001 548 550
152. S. Choi, and S.W. Kim Controlled release of insulin from injectable biodegradable triblock copolymer depot in ZDF rats Pharm. Res. 20 2003 2008 2010 (Pubitemid 38005533)
153. M.F. Shamji Release and activity of anti-TNFα therapeutics from injectable chitosan preparations for local drug delivery J. Biomed. Mater. Res. B: Appl. Biomater. 90 2009 319 326
154. A.T. Hillel Photoactivated composite biomaterial for soft tissue restoration in rodents and in humans Sci. Transl. Med. 3 2011 93ra67