Patients with tuberculosis disease have mycobacterium tuberculosis-specific CD8 T cells with a pro-apoptotic phenotype and impaired proliferative capacity, which is not restored following treatment

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Day, Cheryl L ^a,b,c,d   Moshi, Noella D ^a   Abrahams, Deborah A ^a   Van Rooyen, Michele ^a   O'Rie, Terrence ^a   De Kock, Marwou ^a   Hanekom, Willem A ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY   (United States)

^d EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD57 ANTIGEN; CULTURE FILTRATE PROTEIN 10; EARLY SECRETORY ANTIGENIC TARGET 6; ETHAMBUTOL; FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 7 RECEPTOR; ISONIAZID; KI 67 ANTIGEN; PYRAZINAMIDE; RIFAMPICIN; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CFP-10 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; ESAT-6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; INTERLEUKIN 7 RECEPTOR ALPHA; PROTEIN BCL 2;

ADULT; AGED; ANTIGEN SPECIFICITY; ARTICLE; ASYMPTOMATIC DISEASE; BACTERIAL LOAD; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; HUMAN; LATENT TUBERCULOSIS; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; MYCOBACTERIUM TUBERCULOSIS; PHENOTYPE; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TUBERCULOSIS; ADOLESCENT; APOPTOSIS; CELL PROLIFERATION; DRUG EFFECTS; FLOW CYTOMETRY; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PHYSIOLOGY; TREATMENT OUTCOME; TUBERCULOSIS, PULMONARY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIGENS, BACTERIAL; ANTIGENS, CD57; ANTIGENS, CD95; APOPTOSIS; BACTERIAL PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; INTERFERON-GAMMA; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; KI-67 ANTIGEN; LATENT TUBERCULOSIS; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; TREATMENT OUTCOME; TUBERCULOSIS, PULMONARY; YOUNG ADULT;

EID: 84899739241     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094949     Document Type: Article

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