Tim-3-Expressing CD4+ and CD8+ T Cells in Human Tuberculosis (TB) Exhibit Polarized Effector Memory Phenotypes and Stronger Anti-TB Effector Functions

PLoS Pathogens

Volumn 8, Issue 11, 2012, Pages

  Qiu, Yueqin ^a,b   Chen, Jianbo ^c   Liao, Hongying ^d   Zhang, Yan ^e   Wang, Hua ^e   Li, Shaoyuan ^a   Luo, Yanfen ^a   Fang, Danyun ^a   Li, Guobao ^c   Zhou, Boping ^c   Shen, Ling ^f   Chen, Crystal Y ^g   Huang, Dan ^g   Cai, Jiye ^b   Cao, Kaiyuan ^a   Jiang, Lifang ^a   Zeng, Gucheng ^a   Chen, Zheng W ^g  

^a SUN YAT SEN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

^c SHENZHEN THIRD PEOPLE S HOSPITAL   (China)

^d THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^e SUN YAT SEN UNIVERSITY   (China)

^f HARVARD MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD3 ANTIGEN; CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; ECALECTIN; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 22; INTERLEUKIN 7 RECEPTOR; L SELECTIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA; STAT3 PROTEIN; STAT5 PROTEIN; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING PROTEIN 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DEGRANULATION; DOWN REGULATION; EFFECTOR CELL; EX VIVO STUDY; FLOW CYTOMETRY; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MEMORY T LYMPHOCYTE; MYCOBACTERIUM TUBERCULOSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UPREGULATION;

CD8-POSITIVE T-LYMPHOCYTES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE PROTEINS; SIGNAL TRANSDUCTION; TH1 CELLS; TUBERCULOSIS; TUMOR NECROSIS FACTOR-ALPHA;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84870827413     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002984     Document Type: Article

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