Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Lewinsohn, David M ^a,b   Swarbrick, Gwendolyn M ^a   Cansler, Meghan E ^a   Null, Megan D ^a   Rajaraman, Veena ^a,b   Frieder, Marisa M ^a,b   Sherman, David R ^c   McWeeney, Shannon ^a   Lewinsohn, Deborah A ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

^c SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; EPITOPE; ESAT 6 LIKE PROTEIN 2; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN PE PGRS42; PROTEIN PE9; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; HLA ANTIGEN CLASS 1; PEPTIDE; PEPTIDE LIBRARY;

ANTIGEN DETECTION; ANTIGEN PRESENTING CELL; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; ENZYME LINKED IMMUNOSPOT ASSAY; HUMAN; HUMAN CELL; LATENT TUBERCULOSIS; MOLECULAR CLONING; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE LIBRARY; PROTEOMICS; TUBERCULOSIS; AMINO ACID SEQUENCE; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EPITOPE MAPPING; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MONOCYTE; PATHOLOGY; PHYSIOLOGY; SYNTHESIS;

MYCOBACTERIUM TUBERCULOSIS;

AMINO ACID SEQUENCE; ANTIGENS, CD8; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSPOT ASSAY; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MONOCYTES; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE LIBRARY; PEPTIDES; PROTEOMICS; TUBERCULOSIS;

EID: 84879256835     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067016     Document Type: Article

References (41)

1. Lewinsohn DA, Gold MC, Lewinsohn DM, (2011) Views of immunology: effector T cells. Immunol Rev 240: 25-39.
2. Day CL, Shea AK, Altfeld MA, Olson DP, Buchbinder SP, et al. (2001) Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J Virol 75: 6279-6291.
3. (2008) Global tuberculosis control: surveillance, planning, financing. WHO report 2008. Geneva, Switzerland.
4. (2008) WHO vaccine-preventable diseases: monitoring system 2008 global summary. Geneva, Switzerland.
5. Flynn JL, (2006) Lessons from experimental Mycobacterium tuberculosis infections. Microbes Infect 8: 1179-1188.
6. Barnes PF, Bloch AB, Davidson PT, Snider DE Jr, (1991) Tuberculosis in patients with human immunodeficiency virus infection. N Engl J Med 324: 1644-1650.
7. Oldstone MB, (1994) The role of cytotoxic T lymphocytes in infectious disease: history, criteria, and state of the art. Curr Top Microbiol Immmunol 189: 1-8.
8. Woodworth JS, Behar SM, (2006) Mycobacterium tuberculosis-specific CD8+ T cells and their role in immunity. Crit Rev Immunol 26: 317-352.
9. Lalvani A, Brookes R, Wilkinson RJ, Malin AS, Pathan AA, et al. (1998) Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 95: 270-275.
10. Lewinsohn DM, Zhu L, Madison VJ, Dillon DC, Fling SP, et al. (2001) Classically restricted human CD8+ T lymphocytes derived from Mycobacterium tuberculosis-infected cells: definition of antigenic specificity. J Immunol 166: 439-446.
11. Lewinsohn DA, Winata E, Swarbrick GM, Tanner KE, Cook MS, et al. (2007) Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B. PLoS Pathog 3: 1240-1249.
12. Cho S, Mehra V, Thoma-Uszynski S, Stenger S, Serbina N, et al. (2000) Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis. Proc Natl Acad Sci U S A 97: 12210-12215.
13. Grotzke JE, Lewinsohn DM, (2005) Role of CD8+ T lymphocytes in control of Mycobacterium tuberculosis infection. Microbes Infect 7: 776-788.
14. Gold MC, Cerri S, Smyk-Pearson S, Cansler ME, Vogt TM, et al. (2010) Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol 8: e1000407.
15. Lewinsohn DM, Bement TT, Xu J, Lynch DH, Grabstein KH, et al. (1998) Human purified protein derivative-specific CD4+ T cells use both CD95-dependent and CD95-independent cytolytic mechanisms. J Immunol 160: 2374-2379.
16. Lewinsohn DA, Heinzel AS, Gardner JM, Zhu L, Alderson MR, et al. (2003) Mycobacterium tuberculosis-specific CD8+ T cells preferentially recognize heavily infected cells. Am J Respir Crit Care Med 168: 1346-1352.
17. Hoang TT, Nansen A, Roy S, Billeskov R, Aagaard C, et al. (2009) Distinct differences in the expansion and phenotype of TB10.4 specific CD8 and CD4 T cells after infection with Mycobacterium tuberculosis. PLoS One 4: e5928.
18. van Pinxteren LA, Cassidy JP, Smedegaard BH, Agger EM, Andersen P, (2000) Control of latent Mycobacterium tuberculosis infection is dependent on CD8 T cells. Eur J Immunol 30: 3689-3698.
19. Ordway D, Higgins DM, Sanchez-Campillo J, Spencer JS, Henao-Tamayo M, et al. (2007) XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stability. J Leukoc Biol 82: 1221-1229.
20. Mogues T, Goodrich ME, Ryan L, LaCourse R, North RJ, (2001) The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice. J Exp Med 193: 271-280.
21. Chen CY, Huang D, Wang RC, Shen L, Zeng G, et al. (2009) A critical role for CD8 T cells in a nonhuman primate model of tuberculosis. PLoS Pathog 5: e1000392.
22. Louise R, Skjot V, Agger EM, Andersen P, (2001) Antigen discovery and tuberculosis vaccine development in the post-genomic era. Scand J Infect Dis 33: 643-647.
23. Reed S, Lobet Y, (2005) Tuberculosis vaccine development; from mouse to man. Microbes Infect 7: 922-931.
24. Lewinsohn DA, Lines RA, Lewinsohn DM, (2002) Human dendritic cells presenting adenovirally expressed antigen elicit Mtb-specific CD8+ T cells. Am J Respir Crit Care Med 166: 843-848.
25. Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, et al. (2003) Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J Exp Med 198: 693-704.
26. McDermott AB, Koup RA, (2012) CD8(+) T cells in preventing HIV infection and disease. AIDS 26: 1281-1292.
27. Moss P, Khan N, (2004) CD8(+) T-cell immunity to cytomegalovirus. Hum Immunol 65: 456-464.
28. Andersen P, (1994) Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins. Infect Immun 62: 2536-2544.
29. Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S, (2000) Recombinant bacillus calmette-guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model. Proc Natl Acad Sci U S A 97: 13853-13858.
30. Roberts AD, Sonnenberg MG, Ordway DJ, Furney SK, Brennan PJ, et al. (1995) Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis. Immunology 85: 502-508.
31. Lambert PH, Hawkridge T, Hanekom WA (2009) New vaccines against tuberculosis. Clin Chest Med 30:: 811-826, x.
32. Betts MR, Ambrozak DR, Douek DC, Bonhoeffer S, Brenchley JM, et al. (2001) Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection. J Virol 75: 11983-11991.
33. Lewinsohn DM, Briden AL, Reed SG, Grabstein KH, Alderson MR, (2000) Mycobacterium tuberculosis-reactive CD8+ T lymphocytes: the relative contribution of classical versus nonclassical HLA restriction. J Immunol 165: 925-930.
34. Heinzel AS, Grotzke JE, Lines RA, Lewinsohn DA, McNabb AL, et al. (2002) HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells. J Exp Med 196: 1473-1481.
35. Riddell SR, Watanabe KS, Goodrich JM, Li CR, Agha ME, et al. (1992) Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 257: 238-241.
36. Romani N, Gruner S, Brang D, Kampgen E, Lenz A, et al. (1994) Proliferating dendritic cell progenitors in human blood. J Exp Med 180: 83-93.
37. Brodie SJ, Lewinsohn DA, Patterson BK, Jiyamapa D, Krieger J, et al. (1999) In vivo migration and function of transferred HIV-1-specific cytotoxic T cells Nat Med. 5: 34-41.
38. Grotzke JE, Harriff MJ, Siler AC, Nolt D, Delepine J, et al. (2009) The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle. PLoS Pathog 5: e1000374.
39. Gold MC, Robinson TL, Cook MS, Byrd LK, Ehlinger HD, et al. (2007) Human neonatal dendritic cells are competent in MHC class I antigen processing and presentation. PLoS ONE 2: e957.
40. Kiepiela P, Leslie AJ, Honeyborne I, Ramduth D, Thobakgale C, et al. (2004) Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature 432: 769-775.
41. Aagaard C, Dietrich J, Doherty M, Andersen P, (2009) TB vaccines: current status and future perspectives. Immunol Cell Biol 87: 279-286.