Apoptosis associated with ex vivo down-regulation of Bcl-2 and up-regulation of Fas in potential cytotoxic CD8+ T lymphocytes during HIV infection

Journal of Immunology

Volumn 156, Issue 6, 1996, Pages 2282-2293

  Boudet, Florence ^a   Lecoeur, Hervé ^a   Gougeon, Marie Lise ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN; HLA DR ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; APOPTOSIS; ARTICLE; CELL DEATH; CLONAL ANERGY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DOWN REGULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; PROTO ONCOGENE; REGULATORY MECHANISM; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD95; APOPTOSIS; CELLS, CULTURED; DOWN-REGULATION; HIV INFECTIONS; HUMANS; IMMUNE TOLERANCE; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; T-LYMPHOCYTES, CYTOTOXIC; UP-REGULATION;

EID: 0029980469     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (93)

1. Raff, M C., B A. Barres, J F Burne, H S. Coles, Y. Ishizaki, and M D Jacobson. 1993. Programmed cell death and the control of cell survival: lessons from the nervous system Science 262:695.
2. Cohen, J J. 1993. Apoptosis. Immunol Today 14:126
3. Vaux, D L 1993. Toward an understanding of the molecular mechanisms of physiological cell death Proc. Natl. Acad Sci. USA 90:786.
4. Hockenbery, D , G. Nunez, C Milliman, R. D. Schreiber, and S. J. Korsmeyer. 1990 Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death Nature 348:334.
5. Alnemri, E S , N M Robenson, T F. Fernandes, C. M. Croce, and G. Litwack. 1992. Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells. Proc. Natl Acad Sci. USA 89:7295
6. Jacobson, M D., J. F. Burne, M. P. King, T. Miyashita, J C. Reed, and M. C. Raff 1993 Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature 361:365
7. Vaux, D L., S. Cory, and J M Adams 1988 Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440
8. Reed, J. C 1994 Bcl-2 and the regulation of programmed cell death. J. Cell Biol 124:1
9. Nunez, G , R. Merino, D Grillot, and M Gonzalez-Garcia. 1994 Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival. Immunol Today 15:182
10. Akbar, A. N., N. Borthwick, M. Salmott, W. Gombert, M. Bofill, N. Shamsadeen, D. Pilling, S. Pett, J. E Grundy, and G. Janossy. 1993. The significance of low bcl-2 expression by CD45RO T cells, in normal individuals and patients with acute viral infections the role of apoptosis in T cell memory. J. Exp. Med. 178:427.
11. Akbar, A. N., M. Salmon, J Savill, and G. Janossy. 1993. A possible role for bcl-2 in regulating T-cell memory: a "balancing act" between cell death and survival Immunol. Today 14.526.
12. Salmon, M., D. Pilling, N. J. Borthwick, N. Viner, G. Janossy, P A Bacon, and A. N. Akbar 1994. The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. Eur. J. Immunol 24:892.
13. Itoh, N., S. Yonehara, A. Ishii, M. Yonehara, S. Mizushima, M Sameshima, A. Hase, Y. Seto, and S. Nagata. 1991. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233.
14. Oehm, A , I. Behrmann, W. Falk, M. Pawlita, G. Maier, C. Klas, M. Li-Weber, S. Richards, J. Dhein, B. C. Trauth, H. Ponsting, and P. H. Krammer. 1992. Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily sequence identity with the Fas antigen. J. Biol. Chem. 267:10709.
15. Yonehara, S., A Ishii, and M. Yonehara. 1989. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J. Exp. Med. 169:1747.
16. Trauth, B C., C. Klas, A. M. Peters, S Matzku, P. Moller, W. Falk, K. M. Debatin, and P. H. Krammer. 1989. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245:301.
17. Suda, T., T. Takahashi, P. Golstein, and S. Nagata. 1993. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169.
18. Alderson, M R., T. W. Tough, T. Davis-Smith, S. Braddy, B. Falk, K. A. Schooley, R. G. Goodwin, C. A. Smith, F Ramsdell, and D. H Lynch. 1995. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181:71.
19. Nagata, S , and T Suda. 1995. Fas and Fas ligand: lpr and gld mutations. Immunol. Today 16:39.
20. Yoshino, T., E. Kondo, L. Cao, K Takahashi, K Hayashi, S. Nomura, and T. Akagi. 1994. Inverse expression of Bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes. Blood 83:1856.
21. Iwai, K., T. Miyawaki, T. Takizawa, A. Konno, K. Ohta, A Yachie, H. Seki, and N Taniguchi. 1994 Differential expression of bcl-2 and susceptibility to anti-Fas-mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils. Blood 84:1201.
22. Cauda, R., C. E. Grossi, R. J. Whitley, and A. B. Tilden 1987. Analysis of immune function in herpes zoster patients: demonstration and characterization of suppressor cells. J Immunol 138:1229.
23. + T cells as a sign of in vivo activation in infectious mononucleosis. Clin. Exp. Immunol 83:447.
24. + lymphocyte subsets in acquired immune deficiency syndrome (AIDS). J. Clin. Immunol 8:473
25. Kestens, L , G. Vanham, P. Gigase, G. Young, I. Hannet, F. Vanlangendonck, F. Hulstaert, and B. A. Bach. 1992. Expression of activation antigens. HLA-DR and CD38, on CD8 lymphocytes during HIV-1 infection. AIDS 6:793.
26. Koenig, S , P. Earl, D. Powell, G. Pantaleo, S. Merli, B Moss, and A. S. Fauci 1988 Group-specific, major histocompatibility complex class I-restricted cytotoxic responses to human immunodeficiency virus 1 (HIV-1) envelope proteins by cloned peripheral blood T cells from an HIV-1-infected individual Proc. Natl. Acad. Sci. USA 85:8638.
27. Vanham, G. L. Kestens, G. Penne, C. Gotlav, P. Gigase, R. Colebunders, M Vandenbruaene, J. Goeman, G van der Groen, and J. L. Ceuppens 1991. Subset markers of CD8(+) cells and their relation to enhanced cytotoxic T-cell activity during human immunodeficiency virus infection. J Clin. Immunol 11: 345.
28. Rivière, Y. 1994 Virus-specific cytotoxic T lymphocyte responses in patients infected with the human immunodeficiency virus, HIV-1. Cell. Mol. Biol. 40.45.
29. Gruters, R. A , F G. Terpstra, R. De Jong, C. J Van Noesel, R. A. Van Lier, and F. Miedema. 1990. Selective loss of T cell functions in different stages of HIV infection: early loss of anti-CD3-induced T cell proliferation followed by decreased anti-CD3-induced cytotoxic T lymphocyte generation in AIDS-related complex and AIDS. Eur. J. Immunol. 20:1039.
30. van Noesel, C. J , R. A Gruters, F. G Terpstra, P T. Schellekens, R A. van Lier, and F. Miedema. 1990. Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men J. Clin. Invest. 86:293.
31. Gougeon, M. L , R. Olivier, S. Garcia, D. Guetard, T. Dragic, C. Dauguet, and L. Montagnier. 1991 Demonstration of an engagement process towards cell death by apoptosis in lymphocytes, of HIV infected patients. C. R. Acad. Sci. III 312:529.
32. Meyaard, L., S. A. Otto, R R. Jonker, M. J Mijnster, R. P. Keet, and F. Miedema. 1992 Programmed death of T cells in HIV-1 infection. Science 257.217.
33. Gougeon, M. L., S. Garcia, J. Heeney, R. Tschopp, H. Lecoeur, D. Guetard, V Rame, C Dauguet, and L Montagnier 1993. Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res. Hum Retroviruses 9:553.
34. Gougeon, M. L., and L. Montagnier. 1993. Apoptosis in AIDS Science 260: 1269
35. Walker, B. D., and F Plata. 1990. Cytotoxic T lymphocytes against HIV. AIDS 4:177.
36. +T lymphocytes of patients with AIDS maintain normal broad cytolytic function despite the loss of human immodeficiency virus-specific cytotoxicity. Proc. Natl. Acad. Sci. USA 87:4818.
37. Carmichael, A , X. Jin, P. Sissons, and L. Borysiewicz. 1993. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J. Exp. Med. 177:249.
38. Centers for Disease Control. 1992. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Morb. Mortal Wkly. Rep. 41:1.
39. Goud, B., A. Zahraoui, A. Tavitian, and J Saraste. 1990. Small GTP-binding protein associated with Golgi cisternae Nature 345.553.
40. Schmid, I., C. H. Uittenbogaart, B. Keld, and J. V. Giorgi. 1994. A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry. J. Immunol. Methods 170:145.
41. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J. Exp. Med. 175:331.
42. + T cell depletion in HIV infection? Cell Death Differ. 2:1.
43. Siegel, R. M., M. Katsumata, T. Miyashita, D. C. Louie, M. I. Greene, and J. C. Reed. 1992. Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice. Proc. Natl. Acad. Sci. USA 89:7003.
44. Veis, D. J., C L. Sentman, E. A. Bach, and S. J. Korsmeyer. 1993. Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes J Immunol. 151:2546.
45. Dive, C., C D Gregory, D. J. Phipps, D. L. Evans, A. E. Milner, and A. H Wyllie. 1992 Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. Biochim Biophys Acta 1133:275.
46. Petit, P. X., H. Lecoeur, E. Zorn, C. Dauguet, B. Mignotte, and M.-L Gougeon. 1995 Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. J. Cell Biol. 130.157.
47. + T cells correlates with lymphocyte activation and with disease progression J. Immunol In press.
48. Levacher, M., F. Hulstaert, S. Tallet, S. Ullery, J. J Pocidalo, and B A Bach. 1992. The significance of activation markers on CD8 lymphocytes in human immunodeficiency syndrome, staging and prognostic value. Clin. Exp Immunol. 90:376.
49. Alessio, M., S. Roggero, A. Funaro, L. B. De Monte, L. Peruzzi, M. Geuna, and F. Malavasi. 1990. CD38 molecule: structural and biochemical analysis on human T lymphocytes, thymocytes, and plasma cells. J. Immunol 145:878
50. + T cell expansion in the peripheral blood of HIV-infected persons J. Immunol. 154:1418.
51. Borthwick, N. J., M. Bofill, W. M. Gombert, A. N. Akbar, E. Medina, K. Sagawa, M. C. Lipman, M. A. Johnson, and G. Janossy. 1994. Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28-T cells. AIDS 8:431.
52. + T cells from HIV-infected persons. J Immunol. 153:412.
53. + T cell populations in HIV disease and in anti-HIV immunity Clin. Exp. Immunol. 92:93.
54. Hoffenbach, A., P Langlade-Demoyen, G. Dadaglio, E. Vilmer, F Michel, C. Mayaud, B. Autran, and F Plata 1989. Unusually high frequencies of HIV-specific cytotoxic T lymphocyte's in humans. J. Immunol. 142:452.
55. + T lymphocytes. J Immunol. 144:574
56. Podack, E R , J. D., Young and Z. A. Cohn. 1985. Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules Proc. Natl Acad. Sci USA 82:8629.
57. Nakata, M., M. J. Smyth, Y. Norihisa, A. Kawasaki, Y. Shinkai, K Okumura, and H Yagita. 1990. Constitutive expression of pore-forming protein in peripheral blood gamma/delta T cells: implication for their cytotoxic role in vitro J Exp. Med. 172.1877.
58. Miyawaki, T., T Uehara, R. Nibu, T. Tsuji, A. Yachie, S Yonehara, and N Taniguchi. 1992 Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J. Immunol 149 3753.
59. Jenkins, M. K., P. S. Taylor, S. D Norton, and K B. Urdahl. 1991 CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J Immunol. 147:2461.
60. Gruters, R A., F G Terpsrra, R. E De Goede, J. W. Mulder, F. De Wolf, P. T Schellekens, R A. Van Lier, M Tersmette, and F. Miedema. 1991 Immunological and virological markers in individuals progressing from seroconversion to AIDS AIDS 5:837.
61. Salazar-Gonzalez, J F., D J. Moody, J. V. Giorgi, O. Martinez-Maza, R T. Mitsuyasu, and J. L. Fahey. 1985. Reduced ecto-5′-nucleotidase activity and enhanced OKT10 and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: evidence of CD8 cell immaturity J. Immunol 135:1778.
62. + patients. Am. J. Pathol. 146:1542.
63. + cytotoxic T cells express CD38 and HLA-DR antigens.. J. Immunol. 150:3070.
64. Koup, R. A., J. L Sullivan, P H. Levine, D. Brettler, A. Mahr, G. Mazzara, S. McKenzie, and D. Panicali 1989. Detection of major histocompatibility complex class I-restricted, HIV-speciflc cytotoxic T lymphocytes in the blood of infected hemophiliacs Blood 73:1909.
65. Tsubota, H., C. I. Lord, D I. Watkins, C. Morimoto, and N. L. Letvin. 1989. A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes. J Exp Med. 169:1421.
66. Lowrey, D M., T. Aebischer, K. Olsen, M. Lichtenheld, F. Rupp, H Hengartner, and E. R. Podack. 1989 Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9. Proc. Natl. Acad Sci. USA 86:247
67. Nakata, M., A. Kawasaki, M. Azuma, K. Tsuji, H. Matsuda, Y. Shinkai, H. Yagita, and K. Okumura. 1992. Expression of perforin and cytolytic potential of human peripheral blood lymphocyte subpopulations. Int. Immunol 4:1049.
68. Bajpai, A , B S. Kwon, and Z. Brahmi. 1991 Rapid loss of perforin and serine protease RNA in cytotoxic lymphocytes exposed to sensitive targets. Immunology 74:258.
69. Kagi, D., F. Vignaux, B Ledermann, K. Burki, V. Depraetere, S Nagata, H Hengartner, and P. Golstein. 1994. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 265:528.
70. Lowin, B., M. Hahne, C. Mattmann, and J. Tschopp 1994. Cytolytic T-cell cytotoxicity is mediated through perform and Fas lytic pathways. Nature 370: 650.
71. Gillette-Ferguson, I., and C. L. Sidman. 1994. A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice. Eur. J. Immunol. 24 1181.
72. Vignaux, F., and P. Golstein 1994. Fas-based lymphocyte-mediated cytotoxicity against syngeneic activated lymphocytes: a regulatory pathway? Eur. J. Immunol. 24.923.
73. Vignaux, F., E. Vivier, B. Malissen, V. Depraetere, S. Nagata, and P. Golstein. 1995. TCR/CD3 coupling to Fas-based cytotoxicity J. Exp. Med. 181:781.
74. Dhein, J., H. Walczak, C Baumler, K. M. Debatin, and P. H. Krammer. 1995. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 373:438.
75. Brunner, T., R. J. Mogil, D. La Face, N. J. Yoo, A. Mahboubi, F. Echeverri, S. J Martin, W R. Force, D. H. Lynch, C F. Ware, and D. R Green 1995. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373.441.
76. Pischel, K. D., M. E. Hemler, C Huang, H. G Bluestein, and V. Woods Jr 1987. Use of the monoclonal antibody 12F1 to characterize the differentiation antigen VLA-2. J. Immunol. 138:226.
77. Muro-Cacho, C. A., G Pantaleo, and A. Fauci 1995. Analysis of apoptosis in lymph nodes of HIV-infected persons: intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with the stage of disease or viral burden. J. Immunol. 154:5555
78. Hartley, S. B., M. P. Cooke, D. A. Fulcher, A W. Harris, S Cory, A. Basten, and C. C. Goodnow. 1993. Elimination of self-reactive B lymphocytes proceeds in two stages, arrested development and cell death. Cell 72.325.
79. Testi, R , and L L. Lanier. 1989. Functional expression of CD28 on T cell antigen receptor gamma/delta-bearing T lymphocytes. Eur. J Immunol. 19:185.
80. + T lymphocytes in acute infectious mononucleosis supporting their susceptibility to programmed cell death Blood 82 521.
81. Beverley, P. C. 1990 Is T-cell memory maintained by crossreactive stimulation? Immunol. Today 11:203.
82. Akbar, A. N., M. Salmon, and G. Janossy. 1991. The synergy between naive and memory T cells during activation. Immunol Today 12.184
83. Perez, V L., T. Rowe, J. S. Justement, S. T. Butera, C. H. June, and T. M Folks. 1991. An HIV-1-infected T cell clone defective in IL-2 production and Ca2+ mobilization after CD3 stimulation. J. Immunol. 147:3145.
84. Clerici, M., F. T. Hakim, D. J. Venzon, S Blatt, C. W. Hendrix, T. A. Wynn, and G. M Shearer. 1993. Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. J. Clin. Invest. 91:759.
85. + cytotoxic T lymphocytes. J. Immunol. 143.1518.
86. + precursor subpopulations. J. Immunol 149:2489.
87. Oltvai, Z. N., C L. Milliman, and S. J Korsmeyer. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609
88. Sato, T , M. Hanada, S. Bodrug, S. Irie, N. Iwama, L H. Boise, C. B. Thompson, E. Golemis, L. Fong, H G. Wang, and J. C. Reed. 1994. Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl. Acad Sci. USA 91:9238.
89. Boise, L. H., M Gonzalez-Garcia, C. E. Postema, L Ding, T Lindsten, L. A. Turka, X. Mao, G. Nunez, and C. B Thompson. 1993. bcl-x, a bcl-2 -related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597.
90. Bargou, R. C , K. Bommert, P. Weinmann, P. T Daniel, C. Wagener, M. Y. Mapara, and B. Dörken. 1995. Induction of Bax-α precedes apoptosis in a human B lymphoma cell line: potential role of the bcl-2 gene family in surface IgM-mediated apoptosis. Eur. J. Immunol 25:770.
91. Ho, D. D., A. U. Neumann, A. S. Perelson, W Chen, J. M Leonard, and M. Markowitz. 1995 Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373.123.
92. Wei, X., S. K. Ghosh, M. E Taylor, V. A Johnson, E. A Emini, P. Deutsch, J. D. Lifson, S. Bonhoeffer, M A. Nowak, B H Hahn, M S. Saag, and G. M. Shaw. 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373:117.
93. Banda, N. K., J. Bernier, D. K Kurahara, R. Kurrle, N. Haigwood, R. P. Sekaly, and T. II Finkel. 1992 Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J. Exp. Med 176:1099.