Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Ou, Xiang ^a,b   Liu, Meilian ^a,b   Luo, Hairong ^a   Dong, Lily Q ^b   Liu, Feng ^a,b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; INITIATION FACTOR 4E BINDING PROTEIN 1; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAGB PROTEIN; RHEB PROTEIN; S6 KINASE; TUBERIN; UNCLASSIFIED DRUG; URSOLIC ACID; DEPTOR PROTEIN, MOUSE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MTOR PROTEIN, MOUSE; MULTIPROTEIN COMPLEX; NEUROPEPTIDE; PROTEIN BINDING; RAGB PROTEIN, MOUSE; RHEB PROTEIN, MOUSE; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE; TRITERPENE; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; LYSOSOME; MOUSE; MYOTUBE; NONHUMAN; PROTEIN SYNTHESIS REGULATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; WESTERN BLOTTING; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MYOBLAST; RAPTOR; SKELETAL MUSCLE;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; GENE EXPRESSION REGULATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUCINE; LYSOSOMES; MICE; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; MUSCLE FIBERS, SKELETAL; MYOBLASTS; NEUROPEPTIDES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RAPTORS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRITERPENES; TUMOR SUPPRESSOR PROTEINS;

EID: 84899701589     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095393     Document Type: Article

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