Assessment of the exhalation kinetics of volatile cancer biomarkers based on their physicochemical properties

Journal of Breath Research

Volumn 8, Issue 1, 2014, Pages

  Amann, Anton ^a,b   Mochalski, Pawel ^a   Ruzsanyi, Vera ^a,b   Broza, Yoav Y ^c   Haick, Hossam ^c  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

biomarker; blood solubility; exhalation kinetics; fat solubility; volatile organic compound

Indexed keywords

2 METHYL PROPANE; 5 METHYL TRIDECANE; ACETONE; ALDEHYDE; BENZOPHENONE; BUTANE; CARYOPHYLLENE; HALIDE; HYDROCARBON; ISOPRENE; KETONE; NEOPTERIN; TERPENE; TUMOR MARKER; UNCLASSIFIED DRUG; VOLATILE ORGANIC COMPOUND;

BLOOD SAMPLING; BREATH ANALYSIS; CANCER EPIDEMIOLOGY; DIFFUSION COEFFICIENT; EXHALATION; HUMAN; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; ARTICLE; CHEMISTRY; KINETICS; METHODOLOGY; PHYSIOLOGY;

BREATH TESTS; EXHALATION; HUMANS; KINETICS; PHYSICOCHEMICAL PHENOMENA; TUMOR MARKERS, BIOLOGICAL; VOLATILE ORGANIC COMPOUNDS;

EID: 84899497692     PISSN: 17527155     EISSN: 17527163     Source Type: Journal    
DOI: 10.1088/1752-7155/8/1/016003     Document Type: Review

References (139)

1. Mochalski P, King J, Klieber M, Unterkofler K, Hinterhuber H, Baumann M and Amann A 2013 Blood and breath levels of selected volatile organic compounds in healthy volunteers Analyst 138 2134-45
2. Filipiak W, Sponring A, Mikoviny T, Ager C, Schubert J, Miekisch W, Amann A and Troppmair J 2008 Release of volatile organic compounds (VOCs) from the lung cancer cell line CALU-1 in vitro Cancer Cell Int. 8 17
3. Sponring A, Filipiak W, Mikoviny T, Ager C, Schubert J, Miekisch W, Amann A and Troppmair J 2009 Release of volatile organic compounds from the lung cancer cell line NCI-H2087 in vitro Anticancer Res. 29 419-26
4. Sponring A, Filipiak W, Ager C, Schubert J, Miekisch W, Amann A and Troppmair J 2010 Analysis of volatile organic compounds (VOCs) in the headspace of NCI-H1666 lung cancer cells Cancer Biomarkers A 7 153-61
5. Barash O, Peled N, Hirsch F R and Haick H 2009 Sniffing the unique 'odor print' of non-small-cell lung cancer with gold nanoparticles Small 5 2618-24
6. Filipiak W, Sponring A, Filipiak A, Ager C, Schubert J, Miekisch W, Amann A and Troppmair J 2010 TD-GC-MS analysis of volatile metabolites of human lung cancer and normal cells in vitro Cancer Epidemiol. Biomarkers Prev. 19 182-95
7. Amal H et al 2012 The scent fingerprint of hepatocarcinoma: in-vitro metastasis prediction with volatile organic compounds (VOCs) Int. J. Nanomed. 7 4135-46
8. Barash O, Peled N, Tisch U, Bunn P A Jr, Hirsch F R and Haick H 2012 Classification of lung cancer histology by gold nanoparticle sensors Nanomedicine 8 580-9
9. Peled N, Barash O, Tisch U, Ionescu R, Broza Y Y, Ilouze M, Mattei J, Bunn P A Jr, Hirsch F R and Haick H 2013 Volatile fingerprints of cancer specific genetic mutations Nanomedicine 9 758-66
10. Mochalski P, Sponring A, King J, Unterkofler K, Troppmair J and Amann A 2013 Release and uptake of volatile organic compounds by human hepatocellular carcinoma cells (HepG2) in vitro Cancer Cell Int. 13 72
11. Filipiak W et al 2013 Comparative analyses of volatile organic compounds (VOCs) from patients, tumors and transformed cell lines for the validation of lung cancer-derived breath markers submitted
12. Amann A, Poupart G, Telser S, Ledochowski M, Schmid A and Mechtcheriakov S 2004 Applications of breath gas analysis in medicine Int. J. Mass Spectrom. 239 227-33
13. Baumbach J I, Vautz W, Ruzsanyi V and Freitag L 2005 Metabolites in human breath: ion mobility spectrometers as diagnostic tools for lung diseases Breath Analysis: for Clinical Diagnosis and Therapeutic Monitoring ed A Amann and D Smith (Singapore: World Scientific) pp 53-66
14. Buszewski B, Kesy M, Ligor T and Amann A 2007 Human exhaled air analytics: biomarkers of diseases Biomed. Chromatogr. 21 553-66 (Pubitemid 46937852)
15. Amann A and Smith D (ed) 2013 Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine (Amsterdam: Elsevier)
16. Solga S and Risby T 2013 Issues and challenges in human breath research: perspectives from our experience Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine ed A Amann and D Smith (Amsterdam: Elsevier) pp 19-24
17. Pleil J D, Stiegel M A and Risby T H 2013 Clinical breath analysis: discriminating between human endogenous compounds and exogenous (environmental) chemical confounders J. Breath Res. 7 017107
18. Haick H, Broza Y, Mochalski P, Ruzsanyi V and Amann A 2014 Assessment, origin, and implementation of breath volatile cancer markers Chem. Soc. Rev. 43 1423-49
19. Konvalina G and Haick H 2014 Sensors for breath testing: from nanomaterials to comprehensive disease detection Acc. Chem. Res. 47 66-76
20. Broza Y Y and Haick H 2013 Nanomaterial-based sensors for detection of disease by volatile organic compounds Nanomedicine (Lond.) 8 785-806
21. Tisch U and Haick H 2013 Arrays of nanomaterial-based sensors for breath testing Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine ed A Amann and D Smith (Amsterdam: Elsevier)
22. Tisch U and Haick H 2010 Arrays of chemisensitive monolayer-capped metallic nanoparticles for diagnostic breath testing Rev. Chem. Eng. 26 171-9
23. Tisch U and Haick H 2010 Nanomaterials for cross-reactive sensor arrays MRS Bull. 35 797-803
24. Leja M A, Liu H and Haick H 2013 Breath testing: the future for digestive cancer detection Expert Rev. Gastroenterol. Hepatol. 7 389-91
25. Trefz P, Schmidt M, Oertel P, Obermeier J, Brock B, Kamysek S, Dunkl J, Zimmermann R, Schubert J K and Miekisch W 2013 Continuous real time breath gas monitoring in the clinical environment by proton-transfer-reaction-time-of- flight-mass spectrometry Anal. Chem. 85 10321-9
26. Filipiak W et al 2013 Pathogen-derived breath markers for monitoring of lower respiratory tract infections in mechanically ventilated patients submitted
27. Kazui M, Andreoni K A, Williams G M, Perler B A, Bulkley G B, Beattie C, Donham R T, Sehnert S S, Burdick J F and Risby T H 1994 Visceral lipid peroxidation occurs at reperfusion after supraceliac aortic cross-clamping J. Vasc. Surg. 19 473-7 (Pubitemid 24093981)
28. Pabst F, Miekisch W, Fuchs P, Kischkel S and Schubert J K 2007 Monitoring of oxidative and metabolic stress during cardiac surgery by means of breath biomarkers: an observational study J. Cardiothorac. Surg. 2 37
29. Brown R H, Wagner E M, Cope K A and Risby T H 2009 Propofol and in vivo oxidative stress: effects of preservative J. Breath Res. 3 016003
30. Broza Y Y, Kremer R, Tisch U, Gevorkyan A, Shiban A, Best L A and Haick H 2013 A nanomaterial-based breath test for short-term follow-up after lung tumor resection Nanomedicine (New York) 9 15-21
31. Filipiak W, Sponring A, Baur M M, Ager C, Filipiak A, Wiesenhofer H, Nagl M, Troppmair J and Amann A 2012 Characterization of volatile metabolites taken up by or released from Streptococcus pneumoniae and Haemophilus influenzae by using GC-MS Microbiology 158 3044-53
32. Filipiak W, Sponring A, Baur M M, Filipiak A, Ager C, Wiesenhofer H, Nagl M, Troppmair J and Amann A 2012 Molecular analysis of volatile metabolites released specifically by Staphylococcus aureus and Pseudomonas aeruginosa BMC Microbiol. 12 113
33. Filipiak W, Sponring A, Filipiak A, Baur M M, Ager C, Wiesenhofer H, Margesin R, Nagl M, Troppmair J and Amann A 2013 Volatile organic compounds (VOCs) released by pathogenic microorganisms in vitro: potential breath biomarkers for early-stage diagnosis of disease Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine ed A Amann and D Smith (Amsterdam: Elsevier) pp 463-512
34. Zhu J, Jimenez-Diaz J, Bean H D, Daphtary N A, Aliyeva M I, Lundblad L K and Hill J E 2013 Robust detection of P. aeruginosa and S. aureus acute lung infections by secondary electrospray ionization-mass spectrometry (SESI-MS) breathprinting: from initial infection to clearance J. Breath Res. 7 037106
35. Zhu J, Bean H D, Wargo M J, Leclair L W and Hill J E 2013 Detecting bacterial lung infections: in vivo evaluation of in vitro volatile fingerprints J. Breath Res. 7 016003
36. Tuboly E, Szabo A, Eros G, Mohacsi A, Szabo G, Tengolics R, Rakhely G and Boros M 2013 Determination of endogenous methane formation by photoacoustic spectroscopy J. Breath Res. 7 046004
37. Eisenmann A, Amann A, Said M, Datta B and Ledochowski M 2008 Implementation and interpretation of hydrogen breath tests J. Breath Res. 2 046002
38. de Lacy Costello B P, Ledochowski M and Ratcliffe N M 2013 The importance of methane breath testing: a review J. Breath Res. 7 024001
39. Erhart S et al 2009 3-Heptanone as a potential new marker for valproic acid therapy J. Breath Res. 3 016004
40. Modak A 2009 Breath tests with 13C substrates J. Breath Res. 3 040201
41. Modak A S 2010 Single time point diagnostic breath tests: a review J. Breath Res. 4 017002
42. Wagner D A, Schatz R, Coston R, Curington C, Bolt D and Toskes P P 2011 A new 13C breath test to detect vitamin B12 deficiency: a prevalent and poorly diagnosed health problem J. Breath Res. 5 046001
43. Rubin T, von Haimberger T, Helmke A and Heyne K 2011 Quantitative determination of metabolization dynamics by a real-time 13CO2 breath test J. Breath Res. 5 027102
44. Thacker D L, Modak A, Flockhart D A and Desta Z 2013 Is (+)-[13C]-pantoprazole better than (±) -[13C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity? J. Breath Res. 7 016001
45. Modak A S 2013 Regulatory issues on breath tests and updates of recent advances on [13C]-breath tests J. Breath Res. 7 037103
46. Ruzsanyi V, Mochalski P, Schmid A, Wiesenhofer H, KlieberM, Hinterhuber H and Amann A 2012 Ion mobility spectrometry for detection of skin volatiles J. Chromatogr. B, Anal. Technol. Biomed. Life Sci. 911 84-92
47. Schmidt F M, Vaittinen O, Metsala M, Lehto M, Forsblom C, Groop P H and Halonen L 2013 Ammonia in breath and emitted from skin J. Breath Res. 7 017109
48. Mochalski P, Krapf K, Ager C, Wiesenhofer H, Agapiou A, Statheropoulos M, Fuchs D, Ellmerer E, Buszewski B and Amann A 2012 Temporal profiling of human urine VOCs and its potential role under the ruins of collapsed buildings Toxicol. Mech. Methods 22 502-11
49. Al-Kateb H, de Lacy Costello B and Ratcliffe N 2013 An investigation of volatile organic compounds from the saliva of healthy individuals using headspace-trap/GC-MS J. Breath Res. 7 036004
50. ten Oever J, Mandon J, Netea M G, van Deuren M, Harren F J, Cristescu S M and Pickkers P 2013 Pulmonary infection, and not systemic inflammation, accounts for increased concentrations of exhaled nitric oxide in patients with septic shock J. Breath Res. 7 036003
51. Tarnoki D L et al 2013 Genetic influence on the relation between exhaled nitric oxide and pulse wave reflection J. Breath Res. 7 026008
52. Hirano T, Matsunaga K, Sugiura H, Minakata Y, Koarai A, Akamatsu K, Ichikawa T, Furukawa K and Ichinose M 2013 Relationship between alveolar nitric oxide concentration in exhaled air and small airway function in COPD J. Breath Res. 7 046002
53. Heffler E, Pizzimenti S, Badiu I, Guida G, Ricciardolo F L, Bucca C and Rolla G 2013 Nasal nitric oxide is a marker of poor asthma control J. Breath Res. 7 026009
54. Cristescu S M, Mandon J, Harren F J, Merilainen P and Hogman M 2013 Methods of NO detection in exhaled breath J. Breath Res. 7 017104
55. Boshier P R, Hanna G B and Marczin N 2013 Exhaled nitric oxide as biomarker of acute lung injury: an unfulfilled promise? J. Breath Res. 7 017118
56. Horvath I, Dweik R and Barnes P J 2012 Exhaled nitric oxide comes of age J. Breath Res. 6 040201
57. Högman M 2012 Extended NO analysis in health and disease J. Breath Res. 6 047103
58. Bucca C, Cicolin A, Guida G, Heffler E, Brussino L and Rolla G 2012 Exhaled nitric oxide (FENO) in non-pulmonary diseases J. Breath Res. 6 027104
59. Shorter J H, Nelson D D, McManus J B, Zahniser M S, Sama S R and Milton D K 2011 Clinical study of multiple breath biomarkers of asthma and COPD (NO, CO2, CO and N2O) by infrared laser spectroscopy J. Breath Res. 5 037108
60. McCurdy M R, Sharafkhaneh A, Abdel-Monem H, Rojo J and Tittel F K 2011 Exhaled nitric oxide parameters and functional capacity in chronic obstructive pulmonary disease J. Breath Res. 5 016003
61. Magori E, Hiltawsky K, Fleischer M, Simon E, Pohle R, von Sicard O and Tawil A 2011 Fractional exhaled nitric oxide measurement with a handheld device J. Breath Res. 5 027104
62. Ryter S W and Choi A M 2013 Carbon monoxide in exhaled breath testing and therapeutics J. Breath Res. 7 017111
63. Agapiou A, Mikedi K, Karma S, Giotaki Z K, Kolostoumbis D, Papageorgiou C, Zorba E, Spiliopoulou C, Amann A and Statheropoulos M 2013 Physiology and biochemistry of human subjects during entrapment J. Breath Res. 7 016004
64. Agapiou A, Mochalski P, Schmid A and Amann A 2013 Potential applications of volatile organic compounds in safety and security Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine ed A Amann and D Smith (Amsterdam: Elsevier) pp 515-58
65. Amann A et al 2010 Analysis of exhaled breath for screening of lung cancer patients Mag. Eur. Med. Oncol. 3 106-12
66. Amann A, Corradi M, Mazzone P and Mutti A 2011 Lung cancer biomarkers in exhaled breath Expert Rev. Mol. Diagn. 11 207-17
67. Hakim M, Broza Y Y, Barash O, Peled N, Phillips M, Amann A and Haick H 2012 Volatile organic compounds of lung cancer and possible biochemical pathways Chem. Rev. 112 5949-66
68. Amann A, Telser S, Hofer L, Schmid A and Hinterhuber H 2005 Exhaled breath gas as a biochemical probe during sleep Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring ed A Amann and D Smith (Singapore: World Scientific) pp 305-16
69. King J, Kupferthaler A, Unterkofler K, Koc H, Teschl S, Teschl G, Miekisch W, Schubert J, Hinterhuber H and Amann A 2009 Isoprene and acetone concentration profiles during exercise on an ergometer J. Breath Res. 3 027006
70. King J, Mochalski P, Kupferthaler A, Unterkofler K, Koc H, Filipiak W, Teschl S, Hinterhuber H and Amann A 2010 Dynamic profiles of volatile organic compounds in exhaled breath as determined by a coupled PTR-MS/GC-MS study Physiol. Meas. 31 1169-84
71. King J, Unterkofler K, Teschl G, Teschl S, Mochalski P, Koc H, Hinterhuber H and Amann A 2012 A modeling-based evaluation of isothermal rebreathing for breath gas analyses of highly soluble volatile organic compounds J. Breath Res. 6 016005
72. King J, Kupferthaler A, Frauscher B, Hackner H, Unterkofler K, Teschl G, Hinterhuber H, Amann A and Hogl B 2012 Measurement of endogenous acetone and isoprene in exhaled breath during sleep Physiol. Meas. 33 413-28
73. Winkler K, Herbig J and Kohl I 2013 Real-time metabolic monitoring with proton transfer reaction mass spectrometry J. Breath Res. 7 036006
74. White I R, Willis K A, Whyte C, Cordell R, Blake R S, Wardlaw A J, Rao S, Grigg J, Ellis A M and Monks P S 2013 Real-time multi-marker measurement of organic compounds in human breath: towards fingerprinting breath J. Breath Res. 7 017112
75. Mochalski P, Rudnicka J, Agapiou A, Statheropoulos M, Amann A and Buszewski B 2013 Near real-time VOCs analysis using an aspiration ion mobility spectrometer J. Breath Res. 7 026002
76. Kohl I et al 2013 First observation of a potential non-invasive breath gas biomarker for kidney function J. Breath Res. 7 017110
77. Amann A, King J, Kupferthaler A, Unterkofler K, Koc H, Teschl S and Hinterhuber H 2009 Exhaled breath analysis - quantifying the storage of lipophilic compounds in the human body Proc. Ecopole 3 9-13
78. King J, Koc H, Unterkofler K, Mochalski P, Kupferthaler A, Teschl G, Teschl S, Hinterhuber H and Amann A 2010 Physiological modeling of isoprene dynamics in exhaled breath J. Theor. Biol. 267 626-37
79. Koc H, King J, Teschl G, Unterkofler K, Teschl S, Mochalski P, Hinterhuber H and Amann A 2011 The role of mathematical modeling in VOC analysis using isoprene as a prototypic example J. Breath Res. 5 037102
80. King J, Unterkofler K, Teschl G, Teschl S, Koc H, Hinterhuber H and Amann A 2011 A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone J. Math. Biol. 63 959-99
81. King J, Unterkofler K, Teschl S, Amann A and Teschl G 2011 Breath gas analysis for estimating physiological processes using anesthetic monitoring as a prototypic example Conf. Proc.: Annu. Int. Conf. of the IEEE Engineering in Medicine and Biology Society (2011) pp 1001-4
82. King J, Koc H, Unterkofler K, Teschl G, Teschl S, Mochalski P, Hinterhuber H and Amann A 2013 Physiological modeling for analysis of exhaled breath Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine ed A Amann and D Smith (Amsterdam: Elsevier) pp 27-46
83. Kohl I, Herbig J, Dunkl J, Hansel A, Daniaux M and Hubalek M 2013 Smokers breath as seen by proton-transfer-reaction time-of-flight mass spectrometry (PTR-TOF-MS) Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine ed A Amann and D Smith (Amsterdam: Elsevier)
84. Kushch I et al 2008 Breath isoprene - aspects of normal physiology related to age, gender and cholesterol profile as determined in a proton transfer reaction mass spectrometry study Clin. Chem. Lab. Med. 46 1011-8 (Pubitemid 352000486)
85. Conkle J P, Camp B J and Welch B E 1975 Trace composition of human respiratory gas Arch. Environ. Health 30 290-5
86. Jansson B O and Larsson B T 1969 Analysis of organic compounds in human breath by gas chromatography-mass spectrometry J. Lab. Clin. Med. 74 961-6
87. Gelmont D, Stein R A and Mead J F 1981 Isoprene-the main hydrocarbon in human breath Biochem. Biophys. Res. Commun. 99 1456-60 (Pubitemid 12242937)
88. Bajtarevic A et al 2009 Noninvasive detection of lung cancer by analysis of exhaled breath BMC Cancer 9 348
89. Kohl I, Dunkl J, Herbig J, Hubalek M, Fiegl H and Daniaux M 2012 Zukunft des brustkrebsscreenings-atemgasanalyse für eine zukünftige nicht-invasive medizin Gynäkol. Onkol. 6 21
90. Fuchs D, Jamnig H, Heininger P, Klieber M, Schroecksnadel S, Fiegl M, Hackl M, Denz H and Amann A 2012 Decline of exhaled isoprene in lung cancer patients correlates with immune activation J. Breath Res. 6 027101
91. King J, Mochalski P, Unterkofler K, Teschl G, Klieber M, Stein M, Amann A and Baumann M 2012 Breath isoprene: muscle dystrophy patients support the concept of a pool of isoprene in the periphery of the human body Biochem. Biophys. Res. Commun. 423 526-30
92. Amann A, Miekisch W, Pleil J, Risby T and Schubert W 2010 Methodological issues of sample collection and analysis of exhaled breath European Respiratory Society Monograph 49 ed I Horvath and J C de Jongste (Lausanne: European Respiratory Society) pp 96-114
93. Farhi L E 1967 Elimination of inert gas by the lung Respir. Physiol. 3 1-11
94. Mochalski P, King J, Kupferthaler A, Unterkofler K, Hinterhuber H and Amann A 2011 Measurement of isoprene solubility in water, human blood and plasma by multiple headspace extraction gas chromatography coupled with solid phase microextraction J. Breath Res. 5 046010
95. Mochalski P, King J, Kupferthaler A, Unterkofler K, Hinterhuber H and Amann A 2012 Human blood and plasma partition coefficients for C4-C8 n-alkanes, isoalkanes, and 1-alkenes Int. J. Toxicol. 31 267-75
96. Filser J G, Csanady G A, Denk B, Hartmann M, Kauffmann A, Kessler W, Kreuzer P E, Putz C, Shen J H and Stei P 1996 Toxicokinetics of isoprene in rodents and humans Toxicology 113 278-87 (Pubitemid 26364104)
97. Mork A K and Johanson G 2006 A human physiological model describing acetone kinetics in blood and breath during various levels of physical exercise Toxicol. Lett. 164 6-15
98. Perbellini L, Brugnone F, Caretta D and Maranelli G 1985 Partition coefficients of some industrial aliphatic hydrocarbons (C5-C7) in blood and human tissues Br. J. Indust. Med. 42 162-7 (Pubitemid 15076873)
99. Fiserova-Bergerova V and Diaz M L 1986 Determination and prediction of tissue-gas partition coefficients Int. Arch. Occup. Environ. Health 58 75-87 (Pubitemid 16107582)
100. Zahlsen K, Eide I, Nilsen A M and Nilsen O G 1993 Inhalation kinetics of C8 to C10 1-alkenes and iso-alkanes in the rat after repeated exposures Pharm. Toxicol. 73 163-8 (Pubitemid 23313606)
101. Balaz S and Lukacova V 1999 A model-based dependence of the human tissue/blood partition coefficients of chemicals on lipophilicity and tissue composition Quant. Struct.-Act. Relat. 18 361-8 (Pubitemid 29504991)
102. Meulenberg C J and Vijverberg H P 2000 Empirical relations predicting human and rat tissue:air partition coefficients of volatile organic compounds Toxicol. Appl. Pharm. 165 206-16 (Pubitemid 30429904)
103. Licata A C, Dekant W, Smith C E and Borghoff S J 2001 A physiologically based pharmacokinetic model for methyl tert-butyl ether in humans: implementing sensitivity and variability analyses Toxicol. Sci. 62 191-204 (Pubitemid 32707733)
104. Thrall K D, Gies R A, Muniz J, Woodstock A D and Higgins G 2002 Route-of-entry and brain tissue partition coefficients for common superfund contaminants J. Toxicol. Environ. Health A 65 2075-86 (Pubitemid 35425382)
105. Abraham M H, Ibrahim A and Acree W E Jr 2005 Air to blood distribution of volatile organic compounds: a linear free energy analysis Chem. Res. Toxicol. 18 904-11 (Pubitemid 40705458)
106. Abraham M H and Ibrahim A 2006 Air to fat and blood to fat distribution of volatile organic compounds and drugs: linear free energy analyses Eur. J. Med. Chem. 41 1430-8 (Pubitemid 44880504)
107. Poulin P and Krishnan K 1995 An algorithm for predicting tissue: blood partition coefficients of organic chemicals from n-octanol: water partition coefficient data J. Toxicol. Environ. Health 46 117-29
108. Sander R 1999 Compilation of Henry's law constants for inorganic and organic species of potential importance in environmental chemistry www.mpch-mainz.mpg.de/%7Esander/res/henry.html
109. Poli D, Carbognani P, Corradi M, Goldoni M, Acampa O, Balbi B, Bianchi L, Michele Rusca and Mutti A 2005 Exhaled volatile organic compounds in patients with non-small cell lung cancer: cross sectional and nested short-term follow-up study Respir. Res. 6 71
110. Xue R, Dong L, Zhang S, Deng C, Liu T, Wang J and Shen X 2008 Investigation of volatile biomarkers in liver cancer blood using solid-phase microextraction and gas chromatography/mass spectrometry Rapid Commun. Mass Spectrom. 22 1181-6 (Pubitemid 351600767)
111. Phillips M, Cataneo R N, Ditkoff B A, Fisher P, Greenberg J, Gunawardena R, Kwon C S, Rahbari-Oskoui F and Wong C 2003 Volatile markers of breast cancer in the breath Breast J. 9 184-91 (Pubitemid 36627163)
112. Phillips M, Cataneo R N, Saunders C, Hope P, Schmitt P and Wai J 2010 Volatile biomarkers in the breath of women with breast cancer J. Breath Res. 4 026003
113. Gaspar E M, Lucena A F, Duro da Costa J and Chaves das Neves H 2009 Organic metabolites in exhaled human breath-a multivariate approach for identification of biomarkers in lung disorders J. Chromatogr. A 1216 2749-56
114. Hakim M, Billan S, Tisch U, Peng G, Dvrokind I, Marom O, Abdah-Bortnyak R, Kuten A and Haick H 2011 Diagnosis of head and neck cancer from exhaled breath Br. J. Cancer 104 1649-55
115. Peng G, Hakim M, Broza Y Y, Billan S, Abdah-Bortnyak R, Kuten A, Tisch U and Haick H 2010 Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors Br. J. Cancer 103 542-51
116. Phillips M, Altorki N, Austin J H M, Cameron R B, Cataneo R N, Kloss R, Maxfield R A, Munawar M I, Pass H I and Rashid A 2008 Detection of lung cancer using weighted digital analysis of breath biomarkers Clin. Chim. Acta 393 76-84
117. Phillips M, Cataneo R N, Ditkoff B A, Fisher P, Greenberg J, Gunawardena R, Kwon S C, Tietje O and Wong C 2006 Prediction of breast cancer using volatile biomarkers in the breath Breast Cancer Res. Treat. 99 19-21 (Pubitemid 44168599)
118. Song G, Qin T, Liu H, Xu G B, Pan Y Y, Xiong F X, Gu K S, Sun G P and Chen Z D 2010 Quantitative breath analysis of volatile organic compounds of lung cancer patients Lung Cancer 67 227-31
119. Fuchs P, Loeseken C, Schubert J K and Miekisch W 2010 Breath gas aldehydes as biomarkers of lung cancer Int. J. Cancer 126 2663-70
120. Phillips M, Altorki N, Austin J H M, Cameron R B, Cataneo R N, Greenberg J, Kloss R, Maxfield R A, Munawar M I and Pass H I 2007 Prediction of lung cancer using volatile biomarkers in breath Cancer Biomarkers 3 95-109 (Pubitemid 47103811)
121. Xu Z Q et al 2013 A nanomaterial-based breath test for distinguishing gastric cancer from benign gastric conditions Br. J. Cancer 108 941-50
122. Zou Y, Wang L, Zhao C, Hu Y, Xu S, Ying K, Wang P and Chen X 2013 CEA, SCC and NSE levels in exhaled breath condensate-possible markers for early detection of lung cancer J. Breath Res. 7 047101
123. Filipiak W et al 2012 Dependence of exhaled breath composition on exogenous factors, smoking habits and exposure to air pollutants J. Breath Res. 6 036008
124. Moretti M, Phillips M, Abouzeid A, Cataneo R N and Greenberg J 2004 Increased breath markers of oxidative stress in normal pregnancy and in preeclampsia Am. J. Obstet. Gynecol. 190 1184-90 (Pubitemid 38692195)
125. Phillips M et al 2004 Heart allograft rejection: detection with breath alkanes in low levels (the HARDBALL study) J. Heart Lung Transplant. 23 701-8 (Pubitemid 38721439)
126. Phillips M, Cataneo R N, Cheema T and Greenberg J 2004 Increased breath biomarkers of oxidative stress in diabetes mellitus Clin. Chim. Acta 344 189-94 (Pubitemid 38626154)
127. Phillips M, Cataneo R N, Greenberg J, Grodman R, Gunawardena R and Naidu A 2003 Effect of oxygen on breath markers of oxidative stress Eur. Respir. J. 21 48-51 (Pubitemid 36150300)
128. Phillips M, Cataneo R N, Greenberg J, Grodman R and Salazar M 2003 Breath markers of oxidative stress in patients with unstable angina Heart Dis. 5 95-9 (Pubitemid 36538664)
129. Phillips M, Cataneo R N, Greenberg J, Gunawardena R, Naidu A and Rahbari-Oskoui F 2000 Effect of age on the breath methylated alkane contour, a display of apparent new markers of oxidative stress J. Lab. Clin. Med. 136 243-9
130. Phillips M, Cataneo R N, Greenberg J, Gunawardena R and Rahbari-Oskoui F 2003 Increased oxidative stress in younger as well as in older humans Clin. Chim. Acta 328 83-6 (Pubitemid 36135782)
131. De Lacy Costello B and Ratcliffe N M 2013 Volatile organic compounds (VOCs) found in urine and stool Volatile Biomarkers: Non-invasive Diagnosis in Physiology and Medicine ed A Amann and D Smith (Amsterdam: Elsevier)
132. Penn D J, Oberzaucher E, Grammer K, Fischer G, Soini H A, Wiesler D, NovotnyMV, Dixon S J, Xu Y and Brereton R G 2007 Individual and gender fingerprints in human body odour J. R. Soc. Interface 4 331-40 (Pubitemid 46513063)
133. Soini H A, Klouckova I, Wiesler D, Oberzaucher E, Grammer K, Dixon S J, Xu Y, Brereton R G, Penn D J and Novotny M V 2010 Analysis of volatile organic compounds in human saliva by a static sorptive extraction method and gas chromatography-mass spectrometry J. Chem. Ecol. 36 1035-42
134. Phillips M et al 2008 Detection of lung cancer using weighted digital analysis of breath biomarkers Clin. Chim. Acta 393 76-84
135. Soini H A, Bruce K E, Klouckova I, Brereton R G, Penn D J and Novotny M V 2006 In situ surface sampling of biological objects and preconcentration of their volatiles for chromatographic analysis Anal. Chem. 78 7161-8 (Pubitemid 44607558)
136. Kostelc J G, Preti G, Zelson P R, Tonzetich J and Huggins G R 1981 Volatiles of exogenous origin from the human oral cavity J. Chromatogr. 226 315-23 (Pubitemid 12132000)
137. Mochalski P, Unterkofler K, Hinterhuber H and Amann A 2013 Emission of volatile organic compounds from skin of healthy volunteers submitted
138. de Lacy Costello B, Amann A, Al-Kateb H, Flynn C, Filipiak W and Ratcliffe N M 2013 A review of the volatiles from the healthy human body J. Breath Res. 8 014001
139. Rieder J, Lirk P, Ebenbichler C, Gruber G, Prazeller P, Lindinger W and Amann A 2001 Analysis of volatile organic compounds: possible applications in metabolic disorders and cancer screening Wien. Klin. Wochenschr. 113 181-5 (Pubitemid 32244768)