Molecular analysis of volatile metabolites released specifically by staphylococcus aureus and pseudomonas aeruginosa

BMC Microbiology

Volumn 12, Issue , 2012, Pages

  Filipiak, Wojciech ^a,b   Sponring, Andreas ^a,b   Baur, Maria Magdalena ^a,b   Filipiak, Anna ^a,b   Ager, Clemens ^a,b   Wiesenhofer, Helmut ^a,b   Nagl, Markus ^b   Troppmair, Jakob ^b   Amann, Anton ^a,b  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Adsorptive enrichment; Breath analysis; Gas chromatography mass spectrometry (GCMS); In vitro headspace sampling; Multibed sorption tubes; Pseudomonas aeruginosa; Staphylococcus aureus; Volatile metabolites; Volatile organic compounds (VOCs)

Indexed keywords

1,10 UNDECADIENE; 2 BUTENE; 2 NONANONE; 3 METHYLPYRROLE; ACETALDEHYDE; ACETOIN; ALCOHOL; ALDEHYDE; DIMETHYL SULFIDE; ESTER DERIVATIVE; FORMIC ACID ETHYL ESTER; HYDROCARBON; ISOBUTANOL; ISOVALERALDEHYDE; ISOVALERIC ACID; KETONE; METHYL 2 METHYLBUTYRATE; NITROGEN DERIVATIVE; SULFUR DERIVATIVE; UNCLASSIFIED DRUG; VOLATILE ORGANIC COMPOUND;

ARTICLE; BACTERIAL COUNT; BACTERIUM CULTURE; COLONY FORMING UNIT; MASS FRAGMENTOGRAPHY; MULTIBED SORPTION TUBE; NONHUMAN; PSEUDOMONAS AERUGINOSA; REACTION TIME; STAPHYLOCOCCUS AUREUS; TUBE; ADULT; AGED; BACTERIAL INFECTION; BREATH ANALYSIS; CLASSIFICATION; FEMALE; HUMAN; LUNG DISEASE; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED;

BACTERIA (MICROORGANISMS); PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

ADULT; AGED; AGED, 80 AND OVER; BACTERIAL INFECTIONS; BREATH TESTS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LUNG DISEASES; MALE; MIDDLE AGED; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; VOLATILE ORGANIC COMPOUNDS; YOUNG ADULT;

EID: 84862310904     PISSN: None     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-12-113     Document Type: Article

References (65)

1. Madigan TM, Martinko JM, Dunlap PV, Clark DP, Brock Biology of Microorganisms Pearson Education Inc., San Francisco 12 2009
2. Mims' Medical Microbiology Elsevier, Philadelphia, Goering R, Dockrell H, Zuckermann M, Wakelin D, Roitt I, Mims C, Chiodini P, 2008 22937979
3. Pathophysiology and management of pulmonary infections in cystic fibrosis. Gibson RL, Burns JL, Ramsey BW, Am J Respir Crit Care Med 2003 168 8 918 951 10.1164/rccm.200304-505SO 14555458
4. Mortality rate attributable to ventilator-associated nosocomial pneumonia in an adult intensive care unit: a prospective case-control study. Bercault N, Boulain T, Crit Care Med 2001 29 12 2303 2309 10.1097/00003246-200112000-00012 11801831
5. Spectrum of practice in the diagnosis of nosocomial pneumonia in patients requiring mechanical ventilation in European intensive care units. Koulenti D, Lisboa T, Brun-Buisson C, Krueger W, Macor A, Sole-Violan J, Diaz E, Topeli A, DeWaele J, Carneiro A, et al. Crit Care Med 2009 37 8 2360 2368 10.1097/CCM.0b013e3181a037ac 19531951
6. Characterization of pathogenic bacteria by automated headspace concentration-gas chromatography. Zechman JM, Aldinger S, Labows JN, J Chromatogr 1986 377 49 57 3086354
7. Volatile metabolites from some gram-negative bacteria. Scholler C, Molin S, Wilkins K, Chemosphere 1997 35 7 1487 1495 10.1016/S0045-6535(97)00209-9 9314189
8. Detection of mastitic milk using a gas-sensor array system (electronic nose). Eriksson A, Persson Waller K, Svennersten Sjaunja K, Haugen JE, Lundby F, Lind O, Int Dairy J 2005 15 1193 1201 10.1016/j.idairyj.2004.12.012
9. Identification of volatile organic compounds secreted from cancer tissues and bacterial cultures. Buszewski B, Ulanowska A, Ligor T, Jackowski M, Klodzinska E, Szeliga J, J Chromatogr B Analyt Technol Biomed Life Sci 2008 868 1-2 88 94 18490205
10. Detection of mastitis pathogens by analysis of volatile bacterial metabolites. Hettinga KA, van Valenberg HJ, Lam TJ, van Hooijdonk AC, J Dairy Sci 2008 91 10 3834 3839 10.3168/jds.2007-0941 18832205
11. Detection of volatile metabolites produced by bacterial growth in blood culture media by selected ion flow tube mass spectrometry (SIFT-MS). Allardyce RA, Langford VS, Hill AL, Murdoch DR, J Microbiol Methods 2006 65 2 361 365 10.1016/j.mimet.2005.09.003 16249043
12. Bronchoalveolar lavage examined by solid phase microextraction, gas chromatography-mass spectrometry and selected ion flow tube mass spectrometry. Julak J, Stranska E, Rosova V, Geppert H, Spanel P, Smith D, J Microbiol Methods 2006 65 1 76 86 10.1016/j.mimet.2005.06.009 16048732
13. The rapid evaluation of bacterial growth in blood cultures by selected ion flow tube-mass spectrometry (SIFT-MS) and comparison with the BacT/ALERT automated blood culture system. Scotter JM, Allardyce RA, Langford VS, Hill A, Murdoch DR, J Microbiol Methods 2006 65 3 628 631 10.1016/j.mimet.2005.09.016 16271408
14. On-line monitoring of microbial volatile metabolites by proton transfer reaction-mass spectrometry. Bunge M, Araghipour N, Mikoviny T, Dunkl J, Schnitzhofer R, Hansel A, Schinner F, Wisthaler A, Margesin R, Mark TD, Appl Environ Microbiol 2008 74 7 2179 2186 10.1128/AEM.02069-07 18245241
15. A preliminary comparison of volatile organic compounds in the headspace of cultures of Staphylococcus aureus grown in nutrient, dextrose and brain heart bovine broths measured using a proton transfer reaction mass spectrometer. OHara M, Mayhew C, J Breath Res 2009 3 027001 027008pp 10.1088/1752-7155/3/2/ 027001 21383456
16. Analysis of volatile flavour compounds by proton transfer reaction mass spectrometry: fragmentation patterns and discrimination between isobaric and isomeric compounds. Buhr K, Van Ruth S, Delahunty C, Int J Mass Spec 2002 221 1 7 10.1016/S1387-3806(02)00896-5
17. Determining concentration patterns of volatile compounds in exhaled breath by PTR-MS. Schwarz K, Filipiak W, Amann A, J Breath Res 2009 3 2 027002 10.1088/1752-7155/3/2/027002 21383457
18. The prediction of bacteria type and culture growth phase by an electronic nose with a multi-layer perceptron network. Gardner JW, Craven M, Dow C, Hines EL, Meas Sci Technol 1998 9 120 127 10.1088/0957-0233/9/1/016
19. Flavours of cheese products: metabolic pathways, analytical tools and identification of producing strains. Marilley L, Casey MG, Int J Food Microbiol 2004 90 2 139 159 10.1016/S0168-1605(03)00304-0 14698096
20. Electronic noses and disease diagnostics. Turner AP, Magan N, Nat Rev Microbiol 2004 2 2 161 166 10.1038/nrmicro823 15040263
21. Investigation into the production of 2-Pentylfuran by Aspergillus fumigatus and other respiratory pathogens in vitro and human breath samples. Syhre M, Scotter JM, Chambers ST, Med Mycol 2008 46 3 209 215 10.1080/13693780701753800 18404548
22. The 13C-urea breath test to detect Helicobacter pylori infection: a validated simple methodology with 50mg 13C-urea. Liao CC, Lee CL, Chiang TC, Lee SC, Huang SH, Tu TC, Chen TK, Wu CH, Aliment Pharmacol Ther 2002 16 4 787 792 10.1046/j.1365-2036.2002.01212.x 11929397
23. Implementation and interpretation of hydrogen breath tests. Eisenmann A, Amann A, Said M, Datta B, Ledochowski M, 2008 2(046002)
24. Diagnosis of pneumonia with an electronic nose: correlation of vapor signature with chest computed tomography scan findings. Hockstein NG, Thaler ER, Torigian D, Miller WT, Deffenderfer O, Hanson CW, Laryngoscope 2004 114 10 1701 1705 10.1097/00005537-200410000-00005 15454757
25. Electronic nose prediction of a clinical pneumonia score: biosensors and microbes. Hanson CW, Thaler ER, Anesthesiology 2005 102 1 63 68 10.1097/00000542-200501000-00013 15618788
26. 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung. Scott-Thomas AJ, Syhre S, Pattemore PK, Epton M, Laing R, Pearson J, Chambers ST, BMC Pulm Med 2010 10 56 10.1186/1471-2466-10-56 21054900
27. Uber den Geruchsstoff von Pseudomonas aeruginosa. Mann S, Arch Mikrobiol 1966 54 184 190 10.1007/BF00408715
28. Quinazoline derivatives in pseudomonads. Mann S, Arch Mikrobiol 1967 56 324 329 10.1007/BF00425207 4970237
29. Use of 2-aminoacetophenone production in identification of Pseudomonas aeruginosa. Cox CD, Parker J, J Clin Microbiol 1979 9 4 479 484 110829
30. Headspace analysis of volatile metabolites of Pseudomonas aeruginosa and related species by gas chromatography- mass spectrometry. Labows JN, McGinley KJ, Webster GF, Leyden JJ, J Clin Microbiol 1980 12 4 521 526 6775012
31. The scent of Mycobacterium tuberculosis. Syhre M, Chambers ST, Tuberculosis (Edinb) 2008 88 4 317 323 10.1016/j.tube.2008.01.002
32. The scent of Mycobacterium tuberculosis-part II breath. Syhre M, Manning L, Phuanukoonnon S, Harino P, Chambers ST, Tuberculosis (Edinb) 2009 89 4 263 266 10.1016/j.tube.2009.04.003
33. Detection of 2- pentylfuran in the breath of patients with Aspergillus fumigatus. Chambers ST, Syhre M, Murdoch DR, McCartin F, Epton MJ, Med Mycol 2009 47 5 468 476 10.1080/13693780802475212 19301177
34. Novel diagnostics: progress toward a breath test for invasive Aspergillus fumigatus. Chambers ST, Bhandari S, Scott-Thomas A, Syhre M, Med Mycol 2011 49 Suppl 1 54 S61 20795766
35. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Anonymous, Am J Respir Crit Care Med 2005 171 4 388 416 15699079
36. Studing of sorptive properties of systems for selective VOCs enrichment form air sample. Buszewski B, Ligor T, Filipiak W, Vasconcelos MT, Pompe M, Veber M, Toxicological and Environmental Chemistry 2007 1 51 64
37. Isoprene biosynthesis in Bacillus subtilis via the methylerythritol phosphate pathway. Wagner WP, Helmig D, Fall R, J Nat Prod 2000 63 1 37 40 10.1021/np990286p 10650075
38. Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. Rodriguez-Concepcion M, Boronat A, Plant Physiol 2002 130 3 1079 1089 10.1104/pp.007138 12427975
39. Brooks G, Carroll K, Butel J, Morse S, Jawetz, Melnick & Adelbergs Medical Microbiology The McGraw-Hill Companies, New York 2007
40. Volatile compounds characteristic of sinus-related bacteria and infected sinus mucus: analysis by solid- phase microextraction and gas chromatography-mass spectrometry. Preti G, Thaler E, Hanson CW, Troy M, Eades J, Gelperin A, J Chromatogr B Analyt Technol Biomed Life Sci 2009 877 22 2011 2018 10.1016/j.jchromb.2009.05.028 19553163
41. Addition of oxidizing or reducing agents to the reaction medium influences amino acid conversion to aroma compounds by Lactococcus lactis. Kieronczyk A, Cachon R, Feron G, Yvon M, J Appl Microbiol 2006 101 5 1114 1122 10.1111/j.1365-2672.2006.02999.x 17040235
42. Identity of additional aroma constituents in milk cultures of Streptococcus Lactis var. Maltigenes. Morgan ME, Lindsay RC, Libbey LM, Pereira RL, J Dairy Sci 1966 49 1 15 18 10.3168/jds.S0022-0302(66)87777-9 5952149
43. Cheese flavour formation by amino acid catabolism. Yvon M, Rijnen L, Int Dairy J 2001 11 185 201 10.1016/S0958-6946(01)00049-8
44. Michal G, Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology John Wiley and sons, Inc, New York 1999
45. Bergey's Manual of Determinative Bacteriology Lippincott, Williams and Wilkins, Philadelphia, PA, USA, Holt JG KN, Sneath PHA, Staley JT, Williams ST, 9 2000 22772684
46. Characteristics of aldehyde dehydrogenases of certain aerobic bacteria representing human colonic flora. Nosova T, Jokelainen K, Kaihovaara P, Heine R, Jousimies-Somer H, Salaspuro M, Alcohol Alcohol 1998 33 3 273 280 9632053
47. Black JG, Microbiology Principles and Explorations Wiley, Hoboken (NJ, USA) 7 2008
48. Diversity of L-methionine catabolism pathways in cheese-ripening bacteria. Bonnarme P, Psoni L, Spinnler HE, Appl Environ Microbiol 2000 66 12 5514 5517 10.1128/AEM.66.12.5514-5517.2000 11097940
49. Biochemical pathways for the production of flavour compounds in cheeses during ripening: A review. McSweeney PLH, Sousa MJ, Lait 2000 80 293 324 10.1051/lait:2000127
50. Measurement and biological significance of the volatile sulfur compounds hydrogen sulfide, methanethiol and dimethyl sulfide in various biological matrices. Tangerman A, J Chromatogr B Analyt Technol Biomed Life Sci 2009 877 28 3366 3377 10.1016/j.jchromb.2009.05.026 19505855
51. Conversion of methionine to methional by Lactococcus lactis. Amarita F, Fernandez-Espla D, Requena T, Pelaez C, FEMS Microbiol Lett 2001 204 1 189 195 11682200
52. Detoxification of hydrogen sulfide and methanethiol in the cecal mucosa. Levitt MD, Furne J, Springfield J, Suarez F, DeMaster E, J Clin Invest 1999 104 8 1107 1114 10.1172/JCI7712 10525049
53. Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues: a specialized function of the colonic mucosa. Furne J, Springfield J, Koenig T, DeMaster E, Levitt MD, Biochem Pharmacol 2001 62 2 255 259 10.1016/S0006-2952(01)00657-8 11389886
54. Properties of recombinant Staphylococcus haemolyticus cystathionine beta-lyase (metC) and its potential role in the generation of volatile thiols in axillary malodor. Troccaz M, Benattia F, Borchard G, Clark AJ, Chem Biodivers 2008 5 11 2372 2385 10.1002/cbdv.200890202 19035565
55. Analysis of exhaled breath for screening of lung cancer patients. Amann A, Ligor M, Ligor T, Bajtarevic A, Ager C, Pienz M, Denz H, Fiegl M, Hilbe W, Weiss W, et al. MEMO 2010 3 103 112 10.1007/s12254-010-0216-5
56. Noninvasive detection of lung cancer by analysis of exhaled breath. Bajtarevic A, Ager C, Pienz M, Klieber M, Schwarz K, Ligor M, Ligor T, Filipiak W, Denz H, Fiegl M, et al. BMC Cancer 2009 9 348 10.1186/1471-2407-9-348 19788722
57. Breath isoprene-aspects of normal physiology related to age, gender and cholesterol profile as determined in a proton transfer reaction mass spectrometry study. Kushch I, Arendacka B, Stolc S, Mochalski P, Filipiak W, Schwarz K, Schwentner L, Schmid A, Dzien A, Lechleitner M, et al. Clin Chem Lab Med 2008 46 1011 1018 18605961
58. Breath acetone-aspects of normal physiology related to age and gender as determined in a PTR-MS study. Schwarz K, Pizzini A, Arendacká B, Zerlauth K, Filipiak W, Schmid A, Dzien A, Neuner S, Lechleitner M, Scholl-Bürgi S, et al. J Breath Res 2009 3 027003 027009 pp 10.1088/1752-7155/3/2/027003 21383458
59. Breath analysis: the approach towards clinical applications. Amann A, Spanel P, Smith D, Mini Rev Med Chem 2007 7 115 129 10.2174/138955707779802606 17305586
60. Applications of breath gas analysis in medicine. Amann A, Poupart G, Telser S, Ledochowski M, Schmid A, Mechtcheriakov S, Int J Mass Spectrometry 2004 239 227 233 10.1016/j.ijms.2004.08.010
61. Release of volatile organic compounds (VOCs) from the lung cancer cell line CALU-1 in vitro. Filipiak W, Sponring A, Mikoviny T, Ager C, Schubert J, Miekisch W, Amann A, Troppmair J, Cancer Cell Int 2008 8 17 10.1186/1475-2867-8- 17 19025629
62. Release of volatile organic compounds from the lung cancer cell line NCI-H2087 in vitro. Sponring A, Filipiak W, Mikoviny T, Ager C, Schubert J, Miekisch W, Amann A, Troppmair J, Anticancer Res 2009 29 1 419 426 19331181
63. Analysis of volatile organic compounds (VOCs) in the headspace of NCIH1666 lung cancer cells in vitro. Sponring A, Filipiak W, Ager C, Schubert J, Miekisch W, Amann A, Troppmair J, Cancer Biomark 2010 7 1 9 21045259
64. TD-GC-MS analysis of volatile metabolites of human lung cancer and normal cells in vitro. Filipiak W, Sponring A, Filipiak A, Ager C, Schubert J, Miekisch W, Amann A, Troppmair J, Cancer Epidemiol Biomarkers Prev 2010 19 1 182 195 10.1158/1055-9965.EPI-09-0162 20056637
65. Kleinbaum D, Kupper L, Muller A, Nizam K, Applied Regression Analysis and Other Multivariable Methods Brooks/Cole Publishing Company, Pacific Grove (CA) 1998