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Volumn 5, Issue 22, 2009, Pages 2618-2624

Sniffing the unique "Odor Print" of non-small-cell lung cancer with gold nanoparticles

Author keywords

Breath analysis; Lung cancer; Nanoparticles; Sensors; Volatile organic compounds

Indexed keywords

ARRAY OF SENSORS; BIOCHEMICAL SOURCES; BREATH ANALYSIS; CANCER CELLS; CURE RATE; GOLD NANOPARTICLES; HIGHLY SENSITIVE; LUNG CANCER; NEGATIVE CONTROL; NON SMALL CELL LUNG CANCER; PATTERN RECOGNITION METHOD; PRE-CONCENTRATION TECHNIQUES; SPECTROMETRY TECHNIQUE;

EID: 73349090616     PISSN: 16136810     EISSN: 16136829     Source Type: Journal    
DOI: 10.1002/smll.200900937     Document Type: Article
Times cited : (160)

References (33)
  • 15
    • 73349143815 scopus 로고    scopus 로고
    • PCA is a statistical method to effectively reduce our multidimensional data space to its main components and allow convenient visualization of the differentiation ability of the sensor array. PCA determines the linear combinations of the sensor values so that the maximum variance between all data points can be obtained in mutually orthogonal dimensions
    • PCA is a statistical method to effectively reduce our multidimensional data space to its main components and allow convenient visualization of the differentiation ability of the sensor array. PCA determines the linear combinations of the sensor values so that the maximum variance between all data points can be obtained in mutually orthogonal dimensions.
  • 27
    • 73349109663 scopus 로고    scopus 로고
    • The American Thoracic Society/European Respiratory Society(ATS/ERS) method is designed to avoid potential errors due to failure to distinguish between endogenous and exogenous compounds in the breath and to exclude nasal entrainment of gas. The exogenous VOCs are either directly absorbed through the lung via the inhaled breath or indirectly through the blood or skin. The endogenous VOCs are generated by the cellular biochemical processes of the body and, thus, may provide insight into the body's functioning. Based on this method, the people tested cleared the inhaled air of ambient contaminants by repeatedly inhaling to total lung capacity for 5 min through a mouthpiece that contained a filter cartridge on the inspiratory port, thus removing more than 99.99% of the exogenous VOCs from the air during inspiration. Immediately after the lung washout, the subjects exhaled through a separate exhalation port of the mouthpiece against 10-15 cm H2O pressure to ensure closure
    • 2O pressure to ensure closure ofthe vellum so that nasal entrainment of gas was excluded. Exhaled breath is a mixture of alveolar air and respiratory dead-space air. In this study, subjects first exhaled the dead-space air into a separate bag and then exhaled the alveolar breath into a 750-mL Tedlar sampling bag (purchased from Eco Medics) made from poly(vinyl fluoride),which is chemically inert with respect to most compounds in the breath. The Tedlar bags were reused and thoroughly cleaned prior to each use with flowing N2 gas. A minimum of five bags was collected from each person tested.
  • 28
    • 73349116402 scopus 로고    scopus 로고
    • The presentation of the exhaled breath results in 2D space, instead of 3D space, is forthe sake of consistency with the results presented in Reference [25].
    • The presentation of the exhaled breath results in 2D space, instead of 3D space, is forthe sake of consistency with the results presented in Reference [25].


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.