A physiologically based pharmacokinetic model for methyl tert-butyl ether in humans: Implementing sensitivity and variability analyses

Toxicological Sciences

Volumn 62, Issue 2, 2001, Pages 191-204

  Licata, Amy Collins ^a,b,d   Dekant, Wolfgang ^c   Smith, Charles E ^b   Borghoff, Susan J ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d RTI INTERNATIONAL   (United States)

Author keywords

Methyl tert butyl ether (MTBE); Physiologically based pharmacokinetic (PBPK) model; Sensitivity analysis; Variability analysis

Indexed keywords

FAT; TERT BUTYL METHYL ETHER;

ADIPOSE TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; EXPOSURE; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INHALATION; KIDNEY PARENCHYMA; LIVER; LIVER METABOLISM; LIVER MICROSOME; LUNG PARENCHYMA; MALE; METABOLIC RATE; MICHAELIS MENTEN KINETICS; MODEL; TARGET ORGAN; TISSUE PERFUSION; TOXICOKINETICS;

ADMINISTRATION, INHALATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; METHYL ETHERS; MODELS, BIOLOGICAL; SENSITIVITY AND SPECIFICITY;

EID: 0034894807     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/62.2.191     Document Type: Article

References (46)

1. Biotransformation and kinetics of excretion of methyl-tert-butyl ether in rats and humans
2. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride
3. Methyl-tertiary-butyl ether (MTBE)-a gasoline additive causes testicular and lymphohaematopoietic cancers in rats
4. Oncogenicity studies of inhaled methyl tertiary-butyl ether (MTBE) in CD-1 mice and F-344 rats
5. Pharmacokinetics for regulatory risk analysis: The case of trichloroethylene
6. Linking indoor air and pharmacokinetic models to assess tetrachloroethylene risk
7. Pharmacokinetics for regulatory risk analysis: The case of 1,1,1-trichloroethane (methyl chloroform)
8. Integrating uncertainty and interindividual variability in environmental risk assessment
9. Development of a physiologically based pharmacokinetic model for methyl tertiary-butyl ether and tertiary-butanol in male Fischer-344 rats
10. Metabolism of methyl tertiary-butyl ether by rat hepatic microsomes
11. Physiological parameter values for physiologically based pharmacokinetic models
12. Acute exposure to low-level methyl tertiary-butyl ether (MTBE): Human reactions and pharmacokinetic response
13. Evaluation of the uncertainty in an oral reference dose for methylmercury due to interindividual variability in pharmacokinetics
14. Sensitivity of physiologically based pharmacokinetic models to variation in model parameters: Methylene chloride
15. Health effects of oxygenated fuels
16. Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: Evidence for major roles by cytochromes P450 2A6 and 2E1
17. Applications of sensitivity analysis to a physiologically based pharmacokinetic model for carbon tetrachloride in rats
18. Risk assessment
19. Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues
20. Biological variation: The unsolvable problem in quantitative extrapolation from laboratory animals and other surrogate systems to human populations
21. Accounting for variability in responsiveness in human health risk assessment
22. Toxicology and epidemiology of 1,3-butadiene
23. Metabolism of methyl tert-butyl ether and other gasoline ethers by human liver microsomes and heterologously expressed human cytochromes P450: Identification of CYP2A6 as a major catalyst
24. Role of cytochrome P450 in the metabolism of methyl tert-butyl ether in human livers
25. Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen
26. Uncertainty, variability, and sensitivity analyses in physiological pharmacokinetic models
27. Physiologically based pharmacokinetic modeling in toxicology
28. Physiologically based pharmacokinetic models for gasoline oxygenates: Implementing statistical and mathematical analyses
29. In vivo metabolism of butadiene by mice and rats: A comparison of physiological model predictions and experimental data
30. Health effects of MTBE among New Jersey garage workers
31. Methyl tertiary butyl ether in human blood after exposure to oxygenated fuel in Fairbanks, Alaska
32. Liquid/air partition coefficients of methyl and ethyl t-butyl ethers, t-amyl methyl ether, and t-butyl alcohol
33. Experimental exposure to methyl tertiary-butyl ether: II. Acute effects in humans
34. Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity
35. Individual expression of carcinogen-metabolizing enzymes: Cytochrome P4502A
36. Metabolism of methyl t-butyl ether in human liver microsomes
37. Expression of cytochrome P4502E1 in human liver: Assessment by mRNA, genotype and phenotype
38. Sensory, symptomatic, inflammatory, and ocular responses to and the metabolism of methyl tertiary butyl ether in a controlled human exposure experiment
39. A physiologically based description of the inhalation pharmacokinetics of styrene monomer in rats and humans
40. Exposure to methyl tertiary-butyl ether from oxygenated gasoline in Stamford, Connecticut