A new 13C breath test to detect vitamin B12 deficiency: A prevalent and poorly diagnosed health problem

Journal of Breath Research

Volumn 5, Issue 4, 2011, Pages

  Wagner, David A ^a   Schatz, Richard ^b   Coston, Richard ^b   Curington, Cheryl ^b   Bolt, Daniel ^a   Toskes, Phillip P ^b  

^a METABOLIC SOLUTIONS INC   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 13; PROPIONIC ACID; CARBON; DIAGNOSTIC AGENT;

ADULT; AGED; ARTICLE; BREATH ANALYSIS; CHRONIC PANCREATITIS; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; CROHN DISEASE; CYANOCOBALAMIN DEFICIENCY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIET RESTRICTION; FEMALE; HUMAN; INTESTINE INFECTION; MALE; PRIORITY JOURNAL; ADOLESCENT; COMPARATIVE STUDY; DIFFERENTIAL DIAGNOSIS; FOLLOW UP; INCIDENCE; METABOLISM; METHODOLOGY; MIDDLE AGED; PREVALENCE; PUBLIC HEALTH; REPRODUCIBILITY; UNITED STATES;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BREATH TESTS; CARBON ISOTOPES; DIAGNOSIS, DIFFERENTIAL; FEMALE; FLORIDA; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PREVALENCE; PUBLIC HEALTH; REPRODUCIBILITY OF RESULTS; VITAMIN B 12 DEFICIENCY; YOUNG ADULT;

EID: 83155176965     PISSN: 17527155     EISSN: 17527163     Source Type: Journal    
DOI: 10.1088/1752-7155/5/4/046001     Document Type: Article

References (22)

1. Tucker K L, Rich S, Rosenberg I, Jacques P, Dallal G, Wilson P W and Selhaub J 2000 Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring Study Am. J. Clin. Nutr. 71 514-22 (Pubitemid 30061231)
2. Klee G G 2000 Cobalamin and folate evaluation: measurement of methylmalonic acid and homcysteine vs vitamin B(12) and folate Clin. Chem. 46 (8 Pt 2) 1277-83 (Pubitemid 30643299)
3. Snow C 1999 Laboratory diagnosis of vitamin B12 and folate deficiency Arch. Intern. Med. 159 1289-98
4. Green R 1996 Screening for vitamin B12 deficiency: caveat emptor Ann. Int. Med. 124 509-11 (Pubitemid 26070118)
5. Cooper B A, Fehedy V and Blanshay P 1986 Recognition of deficiency of vitamin B12 using measurement of serum concentration J. Lab. Clin. Med. 107 447-52 (Pubitemid 16014153)
6. Snow C F 1999 Laboratory disgnosis of vitamin B12 and folate deficiency: a guide for the primary care physician Arch. Intern. Med. 159 1289-98 (Pubitemid 29293591)
7. Lindenbaum J, Savage D G, Stabler S P and Allen R H 1990 Diagnosis of cobalamin deficiency: relative sensitivities of seum cobalamin, methylmalonic acid, and total homocysteine concentrations Am. J. Hematol. 34 99-107 (Pubitemid 20180101)
8. Herrmann W, Schorr H, Geisel J and Riegel W 2001 Homocysteine, cystathionine, methylmalonic acid and B-vitamins in patients with renal disease Clin. Chem. Lab. Med. 239 739-46 (Pubitemid 32894421)
9. Magera M J, Helgeson J K, Matern D and Rinaldo P 2000 Methylmalonic acid measured in plasma and urine by stable-isotope dilution and electrospray tandem mass spectrometry Clin. Chem. 46 1804-10 (www.clinchem.org/cgi/content/abstract/ 46/11/1804)
10. Schofield W N 1985 Predicting basal metabolic rate, new standards and review of previous work Hum. Nutr. Clin. Nutr. 39 (Supp. 1) 5-41
11. 2 and their importance in assessing energy expenditure when using tracer techniques Am. J. Physiol. 260 (1 Pt 1) E75-88
12. Fish M B, Pollycove M and Wallerstein R O 1968 In vivo oxidative metabolism of propionic acid in human vitamin B 12 deficiency J. Lab. Clin. Med. 72 767-77
13. Dankert J, Zijlstra J and Wolthers B 1981 Volatile fatty acids in human peripheral and portal blood: quantitative determination, vacuum distillation, and gas chromatography Clin. Chim. Acta 110 301-7 (Pubitemid 11125719)
14. Peters S, Pomare E and Fisher C 1992 Portal and peripheral blood short-chain fatty acid concentrations after caecal lactulose instillation at surgery Gut 33 1249-52
15. DeGrazia J A, Fish M B, Pollycove M, Wallerstein R O and Hollander L 1969 The role of propionic acid as a precursor of methylmalonic acid in normal and vitamin B12-deficient man J. Lab. Clin. Med. 73 917-23
16. Burns S P, Iles R A, Saudubray J M and Chambers R A 1996 Propionylcarnitine excretion is not affected by metronidazole administration to patients with disorders of propionate metabolism Eur. J. Pediatr. 155 31-5
17. Stabler S P, Allen R H, Savage D G and Lindenbaum J 1990 Clinical spectrum and diagnosis of cobalamin deficiency Blood 76 871-81 (Pubitemid 20295496)
18. Johnson M A, Hawthorne N A, Brackett W R, Fischer J G, Gunter E W, Allen R H and Stabler S P 2003 Hyperhomocysteinemia and vitamin B-12 deficiency in elderly using Title IIIc nutrition services Am. J. Clin. Nutr. 77 211-20 (Pubitemid 36015394)
19. Norman E J and Morrison J A 1993 Screening elderly populations for cobalamin (vitamin B12) deficiency using the urinary methylmalonic acid assay by gas chromatography mass spectrometry Am. J. Med. 94 589-94 (Pubitemid 23166704)
20. Elmadfa I and Singer I 2009 Vitamin B-12 and homocysteine status among vegetarians: a global perspective Am. J. Clin. Nutr. 89 1693S-8S
21. Hvas A-M, Ellegaard J and Nexo E 2001 Increased plasma methylmalonic acid level does not predict clinical manifestations of vitamin B12 deficiency Arch. Int. Med. 161 1534-41 (Pubitemid 32679567)
22. Morris M S, Jacques P F, Rosenberg I H and Seleb J 2002 Elevated serum methylmalonic acid concentrations are common among elderly Americans J. Nutr. 132 2799-803 (Pubitemid 35013273)