The scent fingerprint of hepatocarcinoma: In-vitro metastasis prediction with volatile organic compounds (VOCs)

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 4135-4146

  Amal, Haitham ^a   Ding, Lu ^b   Liu, Bin Bin ^c   Tisch, Ulrike ^a   Xu, Zhen Qin ^b   Shi, Da You ^c   Zhao, Yan ^c   Chen, Jie ^c   Sun, Rui Xia ^c   Liu, Hu ^b   Ye, Sheng Long ^c   Tang, Zhao You ^c   Haick, Hossam ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

GC MS; Hepatocarcinoma; Metastasis; Sensor; Volatile organic compound

Indexed keywords

ACETIC ACID; ALCOHOL; COUMARAN; METHANESULFONIL CHLORIDE; UNCLASSIFIED DRUG; VOLATILE ORGANIC COMPOUND;

ANALYTICAL PARAMETERS; ARTICLE; BIOLOGICAL MODEL; CANCER CELL CULTURE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FEASIBILITY STUDY; GAS; HEADSPACE GAS; HIGH METASTATIC POTENTIAL; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; LIVER METASTASIS; LOW METASTATIC POTENTIAL; MASS FRAGMENTOGRAPHY; NANOSENSOR; NANOTECHNOLOGY; PILOT STUDY; PREDICTIVE VALUE; SCENT FINGERPRINT; SENSITIVITY AND SPECIFICITY; VALIDATION PROCESS;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; CELL LINE, TUMOR; DISCRIMINANT ANALYSIS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; LUNG NEOPLASMS; MICE; MICE, NUDE; MODELS, THEORETICAL; NANOTECHNOLOGY; NEOPLASM METASTASIS; PATTERN RECOGNITION, AUTOMATED; REPRODUCIBILITY OF RESULTS; STATISTICS, NONPARAMETRIC; TUMOR MARKERS, BIOLOGICAL; VOLATILE ORGANIC COMPOUNDS;

EID: 84869172237     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S32680     Document Type: Article

References (58)

1. Parkin D, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer. 2001;94(2):153-156.
2. Parkin D. International variation. Oncogene. 2004;23(38): 6329-6340.
3. Hussain SA, Ferry DR, El-Gazzaz G, etal. Hepatocellular carcinoma. Ann Oncol. 2001;12(2):161-172.
4. Nagao T, Inoue S, Yoshimi F, etal. Postoperative recurrence of hepatocellular carcinoma. Ann Surg. 1990;211(1):28-33.
5. Nagao T, Inoue S, Goto S, etal. Hepatic resection for hepatocellularcarcinoma: clinical features and long-term prognosis. Ann Surg. 1987;205(1):33-40.
6. Feng YX, Wang T, Deng YZ, etal. Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model. Hepatology. 2011;53(2):483-492.
7. Welch DR. Technical considerations for studying cancer metastasis in vivo. Clin Exp Metastasis. 1997;15(3):272-306.
8. Tian J, Tang ZY, Ye SL, etal. New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis. Br J Cancer. 1999;81(5):814-821.
9. Li Y, Tian B, Yang J, etal. Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics. J Cancer Res Clin Oncol. 2004;130(8): 460-468.
10. Li JD, Peng Y, Dai Y, Li B, Wei YG, Yan LN. Comparison of the metastatic characteristics of HCCLM3cells and SMCC-7721cells in nude mice model. Zhonghua Gan Zang Bing Za Zhi. 2010;18(1):19-22.
11. Peng G, Tisch U, Adams O, etal. Diagnosing lung cancer in exhaled breath using gold nanoparticles. Nature Nanotechnol. 2009; 4(10):669-673.
12. Chen X, Xu F, Wang Y, etal. A study of the volatile organic compounds exhaled by lung cancer cells in vitro for breath diagnosis. Cancer. 2007;110(4):835-844.
13. Barash O, Peled N, Hirsch FR, Haick H. Sniffing the unique "odor print" of non-small-cell lung cancer with gold nanoparticles. Small (Weinheim an der Bergstrasse, Germany). Nov 2009;5(22):2618-2624.
14. Wehinger A, Schmid A, Mechtcheriakov S, etal. Lung cancer detection by proton transfer reaction mass-spectrometric analysis of human breath gas. Int J Mass spectrom. 2007;265(1):49-59.
15. Preti G, Labows JN, Kostelc JG, Aldinger S, Daniele R. Analysis of lung air from patients with bronchogenic carcinoma and controls using gas chromatography-mass spectrometry. J Chromatogr. 1988; 432:1-11.
16. O'Neill HJ, Gordon SM, O'Neill MH, Gibbons RD, Szidon JP. A computerized classification technique for screening for the presence of breath biomarkers in lung cancer. Clin Chem. 1988;34(8): 1613-1618.
17. Tisch U, Haick H. Arrays of chemisensitive monolayer-capped metallic nanoparticles for diagnostic breath testing. Rev Chem Eng. 2011;26:171-179.
18. Shuster G, Gallimidi Z, Heyman-Reiss A, etal. Classification of breast cancer precursors through exhaled breath. Breast Cancer Res Treat. 2011;126:791-796.
19. Tisch U, Haick H. Nanomaterials for cross-reactive sensor arrays. MRS Bull. 2010;35:797.
20. Tisch U, Haick H. Sensors based on monolayer-capped metal nanoparticles. In: Korotcenkov G, editor. Chemical Sensors-Vol 2: Nanstructured Materials. Vol 2 (Nanstructured Materials). 2010:141-202.
21. Tisch U, Aluf Y, Ionescu R, etal. Detection of asymptomatic nigrostriatal Dopaminergic lesion in rats by exhaled air analysis using carbon nanotube sensors. ACS Chem Neurosci. 2012;3(3):161-166.
22. Hakim M, Billan S, Tisch U, etal. Diagnosis of head-and-neck cancer from exhaled breath. Br J Cancer. 2011;104(10):1649-1655.
23. Peng G, Hakim M, Broza YY, etal. Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors. Br J Cancer. 2010;103(4):542-551.
24. Horváth I, Lázár Z, Gyulai N, Kollai M, Losonczy G. Exhaled biomarkers in lung cancer. Eur Respir J. 2009;34(1):261-275.
25. Amann A, Spanel P, Smith D. Breath analysis: the approach towards clinical applications. Mini Reviews in Med Chem. 2007;7(2):115-129.
26. Alberts B, Johnson A, Lewis J. Molecular Biology of the Cell. 4th ed. New York: Garland Publishing; 2002.
27. Singer SJ, Nicolson GL. The fluid mosaic model of the structure of cell membranes. Science. 1972;175:720-731.
28. Kneepkens CM, Lepage G, Roy CC. The potential of the hydrocarbon breath test as a measure of lipid peroxidation. Free Radic Biol Med. 1994;17(2):127-160.
29. Vousden KH, Ryan KM. p53 and metabolism. Nat Rev Cancer. Oct 2009;9(10):691-700.
30. Okunieff P, Fenton B, Chen Y. Past, present, and future of oxygen in cancer research. Adv Exp Med Biol. 2005;566:213-222.
31. Qin T, Liu H, Song Q, Song G, Wang H, Pan Y. The screening of volatile markers for hepatocellular carcinoma. Cancer Epidemiol Biomarkers and Prev. 2010;19(9):2247-2253.
32. Xue R, Dong L, Zhang S, etal. Investigation of volatile biomarkers in liver cancer blood using solid-phase microextraction and gas chromatography/mass spectrometry. Rapid Commun Mass Spectrom. 2008;22(8):1181-1186.
33. Li Y, Tang ZY, Ye SL, etal. Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97. World J Gastroenterol. 2001;7(5):630-636.
34. Zhang W, Zhu XD, Sun HC, etal. Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects. Clin Cancer Res. 2010;16(13):3420-3430.
35. Zhao R, Wang TZ, Kong D, etal. Hepatoma cell line HepG2.2.15 demonstrates distinct biological features compared with parental HepG2. World J Gastroenterol. 2011;17(9):1152-1159.
36. Sun B-g, Zhang S-j, Liu Y-d, Yin L-r, Chen Z-x. Establishing human hepatoma model from subcutane to orthotopic transplantation with Bel-7402cells in athymic mice and PTEN expression. Chinese Journal of Integrated Traditional And Western Medicine on Digestion. 2007;15(5):297-300.
37. Ding SJ, Li Y, Shao XX, etal. Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials. Proteomics. 2004;4(4):982-994.
38. Tang Z-Y, Sun F-X, Tian J, etal. Metastatic human hepatocellular carcinoma models in nude mice and cell line with metastatic potential. World J Gastroenterol. 2001;7(5):597-601.
39. Peng G, Hakim M, Broza YY, etal. Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors. British Journal of Cancer. 2010;103:542-551.
40. Zilberman Y, Ionescu R, Feng X, Müllen K, Haick H. Nanoarray of polycyclic aromatic hydrocarbons and carbon nanotubes for accurate and predictive detection in real-world environmental humidity. ACS Nano. 2011;5(8):6743-6753.
41. Zilberman Y, Tisch U, Shuster G, etal. Carbon nanotube/Hexa-peri-hexabenzocoronene bilayers for discrimination between nonpolar volatile organic compounds of cancer and humid atmospheres. Adv Mater. 2010;22:4317-4320.
42. Zilberman Y, Tisch U, Pisula W, Feng X, Müllen K, Haick H. Sponge-like structures of Hexa-peri-hexabenzocoronenes derivatives enhances the sensitivity of chemiresistive carbon nanotubes to nonpolar volatile organic compounds. Langmuir. 2009;25(9):5411-5416.
43. Peng G, Trock E, Haick H. Detecting simulated patterns of lung cancer biomarkers by random network of single-walled carbon nanotubes coated with nonpolymeric organic materials. Nano Lett. 2008;8(11):3631-3635.
44. Konvalina G, Haick H. Effect of humidity on nanoparticle-based chemiresistors: a comparison between synthetic and real-world samples. ACS Appl Mater Interfaces. 2012;4(1):317-325.
45. Wilcoxon F. Individual comparisons by ranking methods. Biometrics Bulletin. 1945;1(6):80-83.
46. Siegel S. Nonparametric statistics. The American Statistician. 1957; 11(3):13-19.
47. Ionescu R, Llobet E, Vilanova X, Brezmes J, Sueiras J, Calderer J. Quantitative analysis of NO2 in the presence of CO using a single tungsten oxide semiconductor sensor and dynamic signal processing. Analyst. 2002;127(9):1237-1246.
48. Tisch U, Billan S, Ilouze M, Phillips M, Peled N, Haick H. Volatile Organic Compounds in Exhaled Breath as Biomarkers for the Early Detection and Screening of Lung Cancer. CML Lung Cancer. 2012;5(4):107-117.
49. Fidler IJ. Critical factors in the biology of human cancer metastasis: twenty-eighth GHA. Clowes memorial award lecture. Cancer Res. 1990;19:6130-6138.
50. Rangarajan A, Weinberg RA. Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice. Nat Rev Cancer. 2003;3(12):952-959.
51. Anisimov VN, Ukraintseva SV, Yashin AI. Cancer in rodents: does it tell us about cancer in humans? Nat Rev Cancer. 2005;5(10):807-819.
52. Chen S, Zieve L, Mahadevan V. Mercaptans and dimethyl sulfide in the breath of patients with cirrhosis of the liver. Effect of feeding methionine. J Lab Clin Med. 1970;75(4):628-635.
53. Scislowski P, Pickard K. The regulation of transaminative flux of methionine in rat liver mitochondria. Archives of Biochemistry and Biophysics. 1994;314(2):412-416.
54. Ma S, Chan KW, Lee TKW, etal. Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations. Mol Cancer Res. 2008; 6:1146-1153.
55. Irwin R. NTP technical report on the toxicology and carcinogenesis studies ofbenzofuran (CAS no 271-289-6) in f344/n rats and b6c3f1 mice (gavage studies). Research Triangle Park, NC: US Department of Health and Human Services; 1989.
56. Fan H, Ren Y, Wu X, Wang Q. Synthesis and cytotoxicity of novel benzofuran neolignan derivatives. Journal of Chemical Research. 2010;34:233-235.
57. Manna SK, Bose JS, Gangan V, etal. Novel derivative of benzofuran induces cell death mostly by G2/M cell cycle arrest through p53-dependent pathway but partially by inhibition of NF-kappaB. J Biol Chem. 2010;285(29):22318-22327.
58. Ionescu R, Broza YY, Shaltieli H, etal. Detection of multiple sclerosis from exhaled breath using bilayers of Polycyclic Aromatic Hydrocarbons and single-wall carbon nanotubes. ACS Chem Neurosci. 2011;2:687-693.