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Volumn 267, Issue 4, 2010, Pages 626-637

Physiological modeling of isoprene dynamics in exhaled breath

Author keywords

Breath gas analysis; Hemodynamics; Isoprene; Modeling; Volatile organic compounds

Indexed keywords

ISOPRENE; VOLATILE ORGANIC COMPOUND;

EID: 77957321090     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2010.09.028     Document Type: Article
Times cited : (165)

References (97)
  • 2
    • 84967693161 scopus 로고    scopus 로고
    • Amann, A., Smith, D. (Eds.), Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring. World Scientific, Singapore
    • Amann, A., Smith, D. (Eds.), 2005. Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring. World Scientific, Singapore.
    • (2005)
  • 3
    • 33847788491 scopus 로고    scopus 로고
    • Breath analysis: the approach towards clinical applications
    • Amann A., Spanel P., Smith D. Breath analysis: the approach towards clinical applications. Mini Rev. Med. Chem. 2007, 7:115-129.
    • (2007) Mini Rev. Med. Chem. , vol.7 , pp. 115-129
    • Amann, A.1    Spanel, P.2    Smith, D.3
  • 5
    • 1042300691 scopus 로고    scopus 로고
    • Modeling soluble gas exchange in the airways and alveoli
    • Anderson J.C., Babb A.L., Hlastala M.P. Modeling soluble gas exchange in the airways and alveoli. Ann. Biomed. Eng. 2003, 31:1402-1422.
    • (2003) Ann. Biomed. Eng. , vol.31 , pp. 1402-1422
    • Anderson, J.C.1    Babb, A.L.2    Hlastala, M.P.3
  • 7
    • 0012503255 scopus 로고
    • Statistical methods for model comparison in parameter estimation problems for distributed systems
    • Banks H.T., Fitzpatrick B.G. Statistical methods for model comparison in parameter estimation problems for distributed systems. J. Math. Biol. 1990, 28:501-527.
    • (1990) J. Math. Biol. , vol.28 , pp. 501-527
    • Banks, H.T.1    Fitzpatrick, B.G.2
  • 8
    • 77956011311 scopus 로고    scopus 로고
    • Standard error computations for uncertainty quantification in inverse problems: asymptotic theory vs. bootstrapping
    • in press
    • Banks, H.T., Holm, K., Robbins, D., in press. Standard error computations for uncertainty quantification in inverse problems: asymptotic theory vs. bootstrapping. Math. Comput. Modelling 52, 1610-1625.
    • Math. Comput. Modelling , vol.52 , pp. 1610-1625
    • Banks, H.T.1    Holm, K.2    Robbins, D.3
  • 11
    • 0001622216 scopus 로고
    • Numerical treatment of inverse problems in chemical reaction kinetics
    • Springer, Heidelberg, K. Ebert, P. Deuflhard, W. Jäger (Eds.)
    • Bock H.G. Numerical treatment of inverse problems in chemical reaction kinetics. Modelling of Chemical Reaction Systems 1981, 102-125. Springer, Heidelberg. K. Ebert, P. Deuflhard, W. Jäger (Eds.).
    • (1981) Modelling of Chemical Reaction Systems , pp. 102-125
    • Bock, H.G.1
  • 12
    • 78049527513 scopus 로고
    • Randwertproblemmethoden zur Parameteridentifizierung in Systemen nichtlinearer Differentialgleichungen. Ph.D. Thesis, Universität Bonn
    • Bock, H.G., 1987. Randwertproblemmethoden zur Parameteridentifizierung in Systemen nichtlinearer Differentialgleichungen. Ph.D. Thesis, Universität Bonn.
    • (1987)
    • Bock, H.G.1
  • 13
    • 0035930397 scopus 로고    scopus 로고
    • Prediction of isoprene diepoxide levels in vivo in mouse, rat and man using enzyme kinetic data in vitro and physiologically-based pharmacokinetic modelling
    • Bogaards J.J., Freidig A.P., van Bladeren P.J. Prediction of isoprene diepoxide levels in vivo in mouse, rat and man using enzyme kinetic data in vitro and physiologically-based pharmacokinetic modelling. Chem. Biol. Interact. 2001, 138:247-265.
    • (2001) Chem. Biol. Interact. , vol.138 , pp. 247-265
    • Bogaards, J.J.1    Freidig, A.P.2    van Bladeren, P.J.3
  • 15
    • 0019135838 scopus 로고
    • Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth
    • Brown M.S., Goldstein J.L. Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. J. Lipid Res. 1980, 21:505-517.
    • (1980) J. Lipid Res. , vol.21 , pp. 505-517
    • Brown, M.S.1    Goldstein, J.L.2
  • 16
    • 0036753969 scopus 로고    scopus 로고
    • Practical identifiability of ASM2d parameters-systematic selection and tuning of parameter subsets
    • Brun R., Kühni M., Siegrist H., Gujer W., Reichert P. Practical identifiability of ASM2d parameters-systematic selection and tuning of parameter subsets. Water Res. 2002, 36:4113-4127.
    • (2002) Water Res. , vol.36 , pp. 4113-4127
    • Brun, R.1    Kühni, M.2    Siegrist, H.3    Gujer, W.4    Reichert, P.5
  • 18
    • 0024396146 scopus 로고
    • Isoprene and sleep
    • Cailleux A., Allain P. Isoprene and sleep. Life Sci. 1989, 44:1877-1880.
    • (1989) Life Sci. , vol.44 , pp. 1877-1880
    • Cailleux, A.1    Allain, P.2
  • 19
    • 0026681326 scopus 로고
    • Blood isoprene concentrations in humans and in some animal species
    • Cailleux A., Cogny M., Allain P. Blood isoprene concentrations in humans and in some animal species. Biochem. Med. Metab. Biol. 1992, 47:157-160.
    • (1992) Biochem. Med. Metab. Biol. , vol.47 , pp. 157-160
    • Cailleux, A.1    Cogny, M.2    Allain, P.3
  • 24
    • 0019034031 scopus 로고
    • Parameter and structural identifiability concepts and ambiguities: a critical review and analysis
    • Cobelli C., DiStefano J.J. Parameter and structural identifiability concepts and ambiguities: a critical review and analysis. Am. J. Physiol. 1980, 239:R7-R24.
    • (1980) Am. J. Physiol. , vol.239
    • Cobelli, C.1    DiStefano, J.J.2
  • 26
    • 0035369384 scopus 로고    scopus 로고
    • Toxicokinetics of inhaled and endogenous isoprene in mice, rats, and humans
    • Csanády G.A., Filser J.G. Toxicokinetics of inhaled and endogenous isoprene in mice, rats, and humans. Chem. Biol. Interact. 2001, 135-136:679-685.
    • (2001) Chem. Biol. Interact. , pp. 679-685
    • Csanády, G.A.1    Filser, J.G.2
  • 28
    • 0021193159 scopus 로고
    • In vitro biosynthesis of isoprene from mevalonate utilizing a rat liver cytosolic fraction
    • Deneris E.S., Stein R.A., Mead J.F. In vitro biosynthesis of isoprene from mevalonate utilizing a rat liver cytosolic fraction. Biochem. Biophys. Res. Commun. 1984, 123:691-696.
    • (1984) Biochem. Biophys. Res. Commun. , vol.123 , pp. 691-696
    • Deneris, E.S.1    Stein, R.A.2    Mead, J.F.3
  • 29
    • 38949139462 scopus 로고    scopus 로고
    • Bootstrapping for confidence interval estimation and hypothesis testing for parameters of system dynamics models
    • Dogan G. Bootstrapping for confidence interval estimation and hypothesis testing for parameters of system dynamics models. Syst. Dyn. Rev. 2007, 23:415-436.
    • (2007) Syst. Dyn. Rev. , vol.23 , pp. 415-436
    • Dogan, G.1
  • 30
    • 0014116112 scopus 로고
    • Elimination of inert gas by the lung
    • Farhi L.E. Elimination of inert gas by the lung. Respir. Physiol. 1967, 3:1-11.
    • (1967) Respir. Physiol. , vol.3 , pp. 1-11
    • Farhi, L.E.1
  • 32
    • 78049529288 scopus 로고
    • Fiserova-Bergerova, V. (Ed.), Modeling of Inhalation Exposure to Vapors: Uptake, Distribution, and Elimination. CRC Press, Boca Raton
    • Fiserova-Bergerova, V. (Ed.), 1983. Modeling of Inhalation Exposure to Vapors: Uptake, Distribution, and Elimination. CRC Press, Boca Raton.
    • (1983)
  • 33
    • 69249219178 scopus 로고    scopus 로고
    • Targeting the mevalonate pathway for improved anticancer therapy
    • Fritz G. Targeting the mevalonate pathway for improved anticancer therapy. Curr. Cancer Drug Targets 2009, 9:626-638.
    • (2009) Curr. Cancer Drug Targets , vol.9 , pp. 626-638
    • Fritz, G.1
  • 35
    • 0020963903 scopus 로고
    • Physiologically based pharmacokinetic modeling: principles and applications
    • Gerlowski L.E., Jain R.K. Physiologically based pharmacokinetic modeling: principles and applications. J. Pharm. Sci. 1983, 72:1103-1127.
    • (1983) J. Pharm. Sci. , vol.72 , pp. 1103-1127
    • Gerlowski, L.E.1    Jain, R.K.2
  • 38
    • 25344469867 scopus 로고
    • Pharmacokinetics and endogenous production of isoprene in humans
    • Hartmann M., Kessler W. Pharmacokinetics and endogenous production of isoprene in humans. Naunyn-Schmiedberg's Arch. Pharmacol. 1990, 341(Suppl.):R13.
    • (1990) Naunyn-Schmiedberg's Arch. Pharmacol. , vol.341 , Issue.SUPPL.
    • Hartmann, M.1    Kessler, W.2
  • 39
    • 35748931160 scopus 로고    scopus 로고
    • Data-based identifiability analysis of non-linear dynamical models
    • Hengl S., Kreutz C., Timmer J., Maiwald T. Data-based identifiability analysis of non-linear dynamical models. Bioinformatics 2007, 23:2612-2618.
    • (2007) Bioinformatics , vol.23 , pp. 2612-2618
    • Hengl, S.1    Kreutz, C.2    Timmer, J.3    Maiwald, T.4
  • 42
    • 0025343801 scopus 로고
    • Parameter estimation: local identifiability of parameters
    • Jacquez J.A., Perry T. Parameter estimation: local identifiability of parameters. Am. J. Physiol. 1990, 258:E727-E736.
    • (1990) Am. J. Physiol. , vol.258
    • Jacquez, J.A.1    Perry, T.2
  • 44
    • 0034912589 scopus 로고    scopus 로고
    • Human breath isoprene and its relation to blood cholesterol levels: new measurements and modeling
    • Karl T., Prazeller P., Mayr D., Jordan A., Rieder J., Fall R., Lindinger W. Human breath isoprene and its relation to blood cholesterol levels: new measurements and modeling. J. Appl. Physiol. 2001, 91:762-770.
    • (2001) J. Appl. Physiol. , vol.91 , pp. 762-770
    • Karl, T.1    Prazeller, P.2    Mayr, D.3    Jordan, A.4    Rieder, J.5    Fall, R.6    Lindinger, W.7
  • 45
    • 0036146786 scopus 로고    scopus 로고
    • Biomarkers of some pulmonary diseases in exhaled breath
    • Kharitonov S.A., Barnes P.J. Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers 2002, 7:1-32.
    • (2002) Biomarkers , vol.7 , pp. 1-32
    • Kharitonov, S.A.1    Barnes, P.J.2
  • 47
    • 78049530453 scopus 로고    scopus 로고
    • Dynamic profiles of volatile organic compounds in exhaled breath as determined by a coupled PTR-MS/GC-MS study
    • King J., Mochalski P., Kupferthaler A., Unterkofler K., Koc H., Filipiak W., Teschl S., Hinterhuber H., Amann A. Dynamic profiles of volatile organic compounds in exhaled breath as determined by a coupled PTR-MS/GC-MS study. Physiol. Meas. 2010, 31:1169-1184. URL: 〈https://homepages.fhv.at/ku/karl/pdfs/PhysMeas2010.pdf〉.
    • (2010) Physiol. Meas. , vol.31 , pp. 1169-1184
    • King, J.1    Mochalski, P.2    Kupferthaler, A.3    Unterkofler, K.4    Koc, H.5    Filipiak, W.6    Teschl, S.7    Hinterhuber, H.8    Amann, A.9
  • 48
    • 78049529212 scopus 로고    scopus 로고
    • A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone. Preprint, Breath Research Institute, Austrian Academy of Sciences. URL:
    • King, J., Unterkofler, K., Teschl, G., Teschl, S., Koc, H., Hinterhuber, H., Amann, A., 2010b. A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone. Preprint, Breath Research Institute, Austrian Academy of Sciences. URL: http://arxiv.org/abs/1003.4475.
    • (2010)
    • King, J.1    Unterkofler, K.2    Teschl, G.3    Teschl, S.4    Koc, H.5    Hinterhuber, H.6    Amann, A.7
  • 49
    • 48749097866 scopus 로고    scopus 로고
    • Acetone and isoprene concentrations in exhaled breath in healthy subjects
    • Kinoyama M., Nitta H., Watanabe A., Ueda H. Acetone and isoprene concentrations in exhaled breath in healthy subjects. J. Health Sci. 2008, 54:471-477.
    • (2008) J. Health Sci. , vol.54 , pp. 471-477
    • Kinoyama, M.1    Nitta, H.2    Watanabe, A.3    Ueda, H.4
  • 50
    • 19044400906 scopus 로고    scopus 로고
    • Maximum likelihood estimation in nonlinear mixed effects models
    • Kuhn E., Lavielle M. Maximum likelihood estimation in nonlinear mixed effects models. Comput. Stat. Data Anal. 2005, 49:1020-1038.
    • (2005) Comput. Stat. Data Anal. , vol.49 , pp. 1020-1038
    • Kuhn, E.1    Lavielle, M.2
  • 51
    • 0033664240 scopus 로고    scopus 로고
    • A lung model describing uptake of organic solvents and roles of mucosal blood flow and metabolism in the bronchioles
    • Kumagai S., Matsunaga I. A lung model describing uptake of organic solvents and roles of mucosal blood flow and metabolism in the bronchioles. Inhal. Toxicol. 2000, 12:491-510.
    • (2000) Inhal. Toxicol. , vol.12 , pp. 491-510
    • Kumagai, S.1    Matsunaga, I.2
  • 53
    • 0025974062 scopus 로고
    • Development and utilization of physiologically based pharmacokinetic models for toxicological applications
    • Leung H.W. Development and utilization of physiologically based pharmacokinetic models for toxicological applications. J. Toxicol. Environ. Health 1991, 32:247-267.
    • (1991) J. Toxicol. Environ. Health , vol.32 , pp. 247-267
    • Leung, H.W.1
  • 54
    • 0029810207 scopus 로고    scopus 로고
    • Statistical properties of breath-to-breath variations in ventilation at constant PET,CO2 and PET,O2 in humans
    • Liang P.J., Pandit J.J., Robbins P.A. Statistical properties of breath-to-breath variations in ventilation at constant PET,CO2 and PET,O2 in humans. J. Appl. Physiol. 1996, 81:2274-2286.
    • (1996) J. Appl. Physiol. , vol.81 , pp. 2274-2286
    • Liang, P.J.1    Pandit, J.J.2    Robbins, P.A.3
  • 55
    • 62449177156 scopus 로고    scopus 로고
    • The analysis of healthy volunteers' exhaled breath by the use of solid-phase microextraction and GC-MS
    • Ligor T., Ligor M., Amann A., Ager C., Bachler M., Dzien A., Buszewski B. The analysis of healthy volunteers' exhaled breath by the use of solid-phase microextraction and GC-MS. J. Breath Res. 2008, 2:046006.
    • (2008) J. Breath Res. , vol.2 , pp. 046006
    • Ligor, T.1    Ligor, M.2    Amann, A.3    Ager, C.4    Bachler, M.5    Dzien, A.6    Buszewski, B.7
  • 56
    • 10044271359 scopus 로고    scopus 로고
    • On-line monitoring of volatile organic compounds at pptv levels by means of proton-transfer-reaction mass spectrometry (PTR-MS)-medical applications, food control and environmental research
    • Lindinger W., Hansel A., Jordan A. On-line monitoring of volatile organic compounds at pptv levels by means of proton-transfer-reaction mass spectrometry (PTR-MS)-medical applications, food control and environmental research. Int. J. Mass Spectrom. 1998, 173:191-241.
    • (1998) Int. J. Mass Spectrom. , vol.173 , pp. 191-241
    • Lindinger, W.1    Hansel, A.2    Jordan, A.3
  • 57
    • 0032382401 scopus 로고    scopus 로고
    • Proton-transfer-reaction mass spectrometry (PTR-MS): on-line monitoring of volatile organic compounds at pptv levels
    • Lindinger W., Hansel A., Jordan A. Proton-transfer-reaction mass spectrometry (PTR-MS): on-line monitoring of volatile organic compounds at pptv levels. Chem. Soc. Rev. 1998, 27:347-354.
    • (1998) Chem. Soc. Rev. , vol.27 , pp. 347-354
    • Lindinger, W.1    Hansel, A.2    Jordan, A.3
  • 59
    • 0017846358 scopus 로고
    • On a measure of lack of fit in time series models
    • Ljung G.M., Box G.E.P. On a measure of lack of fit in time series models. Biometrika 1978, 65:297-303.
    • (1978) Biometrika , vol.65 , pp. 297-303
    • Ljung, G.M.1    Box, G.E.P.2
  • 61
  • 62
    • 0034038041 scopus 로고    scopus 로고
    • Dose-response analyses of experimental cancer data
    • Melnick R.L., Kohn M.C. Dose-response analyses of experimental cancer data. Drug Metab. Rev. 2000, 32:193-209.
    • (2000) Drug Metab. Rev. , vol.32 , pp. 193-209
    • Melnick, R.L.1    Kohn, M.C.2
  • 63
    • 0028032364 scopus 로고
    • Isoprene, an endogenous hydrocarbon and industrial chemical induces, multiple organ neoplasia in rodents after 26 weeks of inhalation exposure
    • Melnick R.L., Sills R.C., Roycroft J.H., Chou B.J., Ragan H.A., Miller R.A. Isoprene, an endogenous hydrocarbon and industrial chemical induces, multiple organ neoplasia in rodents after 26 weeks of inhalation exposure. Cancer Res. 1994, 54:5333-5339.
    • (1994) Cancer Res. , vol.54 , pp. 5333-5339
    • Melnick, R.L.1    Sills, R.C.2    Roycroft, J.H.3    Chou, B.J.4    Ragan, H.A.5    Miller, R.A.6
  • 64
    • 33746216893 scopus 로고    scopus 로고
    • From highly sophisticated analytical techniques to life-saving diagnostics: technical developments in breath analysis
    • Miekisch W., Schubert J.K. From highly sophisticated analytical techniques to life-saving diagnostics: technical developments in breath analysis. Trends Anal. Chem. 2006, 25:665-673.
    • (2006) Trends Anal. Chem. , vol.25 , pp. 665-673
    • Miekisch, W.1    Schubert, J.K.2
  • 65
    • 4143053648 scopus 로고    scopus 로고
    • Diagnostic potential of breath analysis-focus on volatile organic compounds
    • Miekisch W., Schubert J.K., Noeldge-Schomburg G.F.E. Diagnostic potential of breath analysis-focus on volatile organic compounds. Clin. Chim. Acta 2004, 347:25-39.
    • (2004) Clin. Chim. Acta , vol.347 , pp. 25-39
    • Miekisch, W.1    Schubert, J.K.2    Noeldge-Schomburg, G.F.E.3
  • 68
    • 0021886452 scopus 로고
    • Isoprene metabolism by liver microsomal mono-oxygenases
    • Monte M.D., Citti L., Gervasi P.G. Isoprene metabolism by liver microsomal mono-oxygenases. Xenobiotica 1985, 15:591-597.
    • (1985) Xenobiotica , vol.15 , pp. 591-597
    • Monte, M.D.1    Citti, L.2    Gervasi, P.G.3
  • 69
    • 33646099147 scopus 로고    scopus 로고
    • A human physiological model describing acetone kinetics in blood and breath during various levels of physical exercise
    • Mörk A.K., Johanson G. A human physiological model describing acetone kinetics in blood and breath during various levels of physical exercise. Toxicol. Lett. 2006, 164:6-15.
    • (2006) Toxicol. Lett. , vol.164 , pp. 6-15
    • Mörk, A.K.1    Johanson, G.2
  • 70
    • 70349966232 scopus 로고    scopus 로고
    • Bayesian population analysis of a washin-washout physiologically based pharmacokinetic model for acetone
    • Mörk A.-K., Jonsson F., Johanson G. Bayesian population analysis of a washin-washout physiologically based pharmacokinetic model for acetone. Toxicol. Appl. Pharmacol. 2009, 240:423-432.
    • (2009) Toxicol. Appl. Pharmacol. , vol.240 , pp. 423-432
    • Mörk, A.-K.1    Jonsson, F.2    Johanson, G.3
  • 71
    • 0031819043 scopus 로고    scopus 로고
    • Exhaled isoprene and acetone in newborn infants and in children with diabetes mellitus
    • Nelson N., Lagesson V., Nosratabadi A.R., Ludvigsson J., Tagesson C. Exhaled isoprene and acetone in newborn infants and in children with diabetes mellitus. Pediatr. Res. 1998, 44:363-367.
    • (1998) Pediatr. Res. , vol.44 , pp. 363-367
    • Nelson, N.1    Lagesson, V.2    Nosratabadi, A.R.3    Ludvigsson, J.4    Tagesson, C.5
  • 72
    • 78049528936 scopus 로고    scopus 로고
    • NTP, Toxicology and carcinogenesis studies of isoprene (CAS No. 78-79-5) in F344/N rats (inhalation studies). Technical Report NTP-TR-486, NIH Publication No. 97-3976. Technical Report, National Toxicology Program, Research Triangle Park, NC.
    • NTP, 1999. Toxicology and carcinogenesis studies of isoprene (CAS No. 78-79-5) in F344/N rats (inhalation studies). Technical Report NTP-TR-486, NIH Publication No. 97-3976. Technical Report, National Toxicology Program, Research Triangle Park, NC.
    • (1999)
  • 74
    • 36849055638 scopus 로고    scopus 로고
    • Monitoring of oxidative and metabolic stress during cardiac surgery by means of breath biomarkers: an observational study
    • Pabst F., Miekisch W., Fuchs P., Kischkel S., Schubert J.K. Monitoring of oxidative and metabolic stress during cardiac surgery by means of breath biomarkers: an observational study. J. Cardiothorac. Surg. 2007, 2:37.
    • (2007) J. Cardiothorac. Surg. , vol.2 , pp. 37
    • Pabst, F.1    Miekisch, W.2    Fuchs, P.3    Kischkel, S.4    Schubert, J.K.5
  • 75
    • 33947641481 scopus 로고    scopus 로고
    • Parameter estimation in ordinary differential equations for biochemical processes using the method of multiple shooting
    • Peifer M., Timmer J. Parameter estimation in ordinary differential equations for biochemical processes using the method of multiple shooting. IET Syst. Biol. 2007, 1:78-88.
    • (2007) IET Syst. Biol. , vol.1 , pp. 78-88
    • Peifer, M.1    Timmer, J.2
  • 76
    • 52949136674 scopus 로고    scopus 로고
    • Role of exhaled breath biomarkers in environmental health science
    • Pleil J.D. Role of exhaled breath biomarkers in environmental health science. J. Toxicol. Environ. Health B Crit. Rev. 2008, 11:613-629.
    • (2008) J. Toxicol. Environ. Health B Crit. Rev. , vol.11 , pp. 613-629
    • Pleil, J.D.1
  • 77
    • 84967495570 scopus 로고    scopus 로고
    • The unique value of breath biomarkers for estimating pharmacokinetic rate constants and body burden from environmental exposures
    • World Scientific, Singapore, A. Amann, D. Smith (Eds.)
    • Pleil J.D., Kim D., Prah J.D., Ashley D.L., Rappaport S.M. The unique value of breath biomarkers for estimating pharmacokinetic rate constants and body burden from environmental exposures. Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring 2005, 347-359. World Scientific, Singapore. A. Amann, D. Smith (Eds.).
    • (2005) Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring , pp. 347-359
    • Pleil, J.D.1    Kim, D.2    Prah, J.D.3    Ashley, D.L.4    Rappaport, S.M.5
  • 78
    • 84890762143 scopus 로고    scopus 로고
    • Physiologically Based Pharmacokinetic Modeling: Science and Applications. Wiley, Hoboken
    • Reddy, M.B., Yang, R.S.H., Clewell III, H.J., Andersen, M.E., 2005. Physiologically Based Pharmacokinetic Modeling: Science and Applications. Wiley, Hoboken.
    • (2005)
    • Reddy, M.B.1    Yang, R.S.H.2    Clewell, H.J.3    Andersen, M.E.4
  • 80
    • 33751423943 scopus 로고    scopus 로고
    • Novel metaheuristic for parameter estimation in nonlinear dynamic biological systems
    • Rodriguez-Fernandez M., Egea J.A., Banga J.R. Novel metaheuristic for parameter estimation in nonlinear dynamic biological systems. BMC Bioinformatics 2006, 7:483.
    • (2006) BMC Bioinformatics , vol.7 , pp. 483
    • Rodriguez-Fernandez, M.1    Egea, J.A.2    Banga, J.R.3
  • 81
    • 18444383957 scopus 로고    scopus 로고
    • Potential applications of breath isoprene as a biomarker in modern medicine: a concise overview
    • Salerno-Kennedy R., Cashman K.D. Potential applications of breath isoprene as a biomarker in modern medicine: a concise overview. Wien. Klin. Wochenschr. 2005, 117:180-186.
    • (2005) Wien. Klin. Wochenschr. , vol.117 , pp. 180-186
    • Salerno-Kennedy, R.1    Cashman, K.D.2
  • 82
    • 68149114145 scopus 로고    scopus 로고
    • Determining concentration patterns of volatile compounds in exhaled breath by PTR-MS
    • (15)
    • Schwarz K., Filipiak W., Amann A. Determining concentration patterns of volatile compounds in exhaled breath by PTR-MS. J. Breath Res. 2009, 3:027002. (15pp.).
    • (2009) J. Breath Res. , vol.3 , pp. 027002
    • Schwarz, K.1    Filipiak, W.2    Amann, A.3
  • 85
    • 0029036261 scopus 로고
    • Characterization of aspen isoprene synthase, an enzyme responsible for leaf isoprene emission to the atmosphere
    • Silver G.M., Fall R. Characterization of aspen isoprene synthase, an enzyme responsible for leaf isoprene emission to the atmosphere. J. Biol. Chem. 1995, 270:13010-13016.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13010-13016
    • Silver, G.M.1    Fall, R.2
  • 86
    • 0032724364 scopus 로고    scopus 로고
    • Trace gases in breath of healthy volunteers when fasting and after a protein-calorie meal: a preliminary study
    • Smith D., Spanel P., Davies S. Trace gases in breath of healthy volunteers when fasting and after a protein-calorie meal: a preliminary study. J. Appl. Physiol. 1999, 87:1584-1588.
    • (1999) J. Appl. Physiol. , vol.87 , pp. 1584-1588
    • Smith, D.1    Spanel, P.2    Davies, S.3
  • 87
    • 76249132107 scopus 로고    scopus 로고
    • Isoprene levels in the exhaled breath of 200 healthy pupils within the age range 7-18 years studied using SIFT-MS
    • Smith D., Spanel P., Enderby B., Lenney W., Turner C., Davies S.J. Isoprene levels in the exhaled breath of 200 healthy pupils within the age range 7-18 years studied using SIFT-MS. J. Breath Res. 2010, 4:017101.
    • (2010) J. Breath Res. , vol.4 , pp. 017101
    • Smith, D.1    Spanel, P.2    Enderby, B.3    Lenney, W.4    Turner, C.5    Davies, S.J.6
  • 88
    • 0027250730 scopus 로고
    • Effect of regulating cholesterol biosynthesis on breath isoprene excretion in men
    • Stone B.G., Besse T.J., Duane W.C., Evans C.D., DeMaster E.G. Effect of regulating cholesterol biosynthesis on breath isoprene excretion in men. Lipids 1993, 28:705-708.
    • (1993) Lipids , vol.28 , pp. 705-708
    • Stone, B.G.1    Besse, T.J.2    Duane, W.C.3    Evans, C.D.4    DeMaster, E.G.5
  • 89
    • 0024432116 scopus 로고
    • Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure. Muscle blood flow is reduced with maintenance of arterial perfusion pressure
    • Sullivan M.J., Knight J.D., Higginbotham M.B., Cobb F.R. Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure. Muscle blood flow is reduced with maintenance of arterial perfusion pressure. Circulation 1989, 80:769-781.
    • (1989) Circulation , vol.80 , pp. 769-781
    • Sullivan, M.J.1    Knight, J.D.2    Higginbotham, M.B.3    Cobb, F.R.4
  • 90
    • 0030786403 scopus 로고    scopus 로고
    • Detection of isoprene in expired air from human subjects using proton-transfer-reaction mass spectrometry
    • Taucher J., Hansel A., Jordan A., Fall R., Futrell J.H., Lindinger W. Detection of isoprene in expired air from human subjects using proton-transfer-reaction mass spectrometry. Rapid Commun. Mass Spectrom. 1997, 11:1230-1234.
    • (1997) Rapid Commun. Mass Spectrom. , vol.11 , pp. 1230-1234
    • Taucher, J.1    Hansel, A.2    Jordan, A.3    Fall, R.4    Futrell, J.H.5    Lindinger, W.6
  • 91
    • 0035996381 scopus 로고    scopus 로고
    • Estimation of thigh muscle and adipose tissue volume using magnetic resonance imaging and anthropometry
    • Tothill P., Stewart A.D. Estimation of thigh muscle and adipose tissue volume using magnetic resonance imaging and anthropometry. J. Sports Sci. 2002, 20:563-576.
    • (2002) J. Sports Sci. , vol.20 , pp. 563-576
    • Tothill, P.1    Stewart, A.D.2
  • 92
    • 29244462954 scopus 로고    scopus 로고
    • A longitudinal study of breath isoprene in healthy volunteers using selected ion flow tube mass spectrometry (SIFT-MS)
    • Turner C., Spanel P., Smith D. A longitudinal study of breath isoprene in healthy volunteers using selected ion flow tube mass spectrometry (SIFT-MS). Physiol. Meas. 2006, 27:13-22.
    • (2006) Physiol. Meas. , vol.27 , pp. 13-22
    • Turner, C.1    Spanel, P.2    Smith, D.3
  • 93
    • 0026638564 scopus 로고
    • Ventilation-perfusion matching during exercise
    • Wagner P. Ventilation-perfusion matching during exercise. Chest 1992, 101:192S-198S.
    • (1992) Chest , vol.101
    • Wagner, P.1
  • 94
    • 46149102671 scopus 로고    scopus 로고
    • The multiple inert gas elimination technique (MIGET)
    • Wagner P.D. The multiple inert gas elimination technique (MIGET). Intensive Care Med. 2008, 34:994-1001.
    • (2008) Intensive Care Med. , vol.34 , pp. 994-1001
    • Wagner, P.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.