Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells

Biochimie

Volumn 101, Issue 1, 2014, Pages 50-59

  Hou, Xiaoming ^a   Chen, Xing ^a   Zhang, Ping ^b   Fan, Youfei ^a   Ma, Aihua ^a   Pang, Tingting ^a   Song, Zhao ^a   Jin, Youpeng ^a   Hao, Wei ^a   Liu, Fengqin ^a   Wang, Wei ^a   Wang, Yulin ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

AKT inhibitor; Apoptosis; GANT58; GLI1; T ALL

Indexed keywords

4 [2 (4 AMINO 1,2,5 OXADIAZOL 3 YL) 1 ETHYL 7 (3 PIPERIDINYLMETHOXY) 1H IMIDAZO[4,5 C]PYRIDIN 4 YL] 2 METHYL 3 BUTYN 2 OL; ANTINEOPLASTIC AGENT; CYCLOPAMINE; GANT58; GLI1 PROTEIN, HUMAN; OXADIAZOLE DERIVATIVE; PERIFOSINE; PHOSPHORYLCHOLINE; PROTEIN KINASE B; PYRIDINE DERIVATIVE; SONIC HEDGEHOG PROTEIN; THIOPHENE DERIVATIVE; TRANSCRIPTION FACTOR; VERATRUM ALKALOID;

ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; APOPTOSIS; DRUG EFFECTS; DRUG POTENTIATION; DRUG SCREENING; HUMAN; JURKAT CELL LINE; METABOLISM; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; HEDGEHOG PROTEINS; HUMANS; JURKAT CELLS; MAP KINASE SIGNALING SYSTEM; OXADIAZOLES; PHOSPHORYLCHOLINE; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; THIOPHENES; TRANSCRIPTION FACTORS; VERATRUM ALKALOIDS;

EID: 84899447245     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2013.12.019     Document Type: Article

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