Protein kinase A, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells

Journal of Biological Chemistry

Volumn 282, Issue 52, 2007, Pages 37370-37377

  Ji, Zhenyu ^a   Mei, Fang C ^a   Johnson, Betty H ^a   Thompson, E Brad ^a   Cheng, Xiaodong ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA CELLS; GLUCOCORTICOID SENSITIVITY; PROTEIN KINASE;

CELL DEATH; DISEASES; ENZYME INHIBITION; PROTEINS;

ENZYME ACTIVITY;

ANTIPORTER; CASPASE 3; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RECEPTOR; GLUCOCORTICOID; PROTEIN EPAC; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL CYCLE ARREST; CELL GROWTH; CELL KILLING; CELL LINEAGE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; HORMONE SENSITIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; T LYMPHOCYTE;

APOPTOSIS; CASPASE 3; CELL CYCLE; CELL SURVIVAL; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, LEUKEMIC; GLUCOCORTICOIDS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEDGEHOG PROTEINS; HUMANS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TIME FACTORS;

ERINACEIDAE;

EID: 38049115661     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703697200     Document Type: Article

References (49)

1. Thompson, E. B. (1999) Trends Endocrinol. Metab 10, 353-358
2. Medh, R. D., Wang, A., Zhou, F., and Thompson, E. B. (2001) Oncogene 20, 4629-4639
3. Thulasi, R., Harbour, D. V., and Thompson, E. B. (1993) J. Biol. Chem. 268, 18306-18312
4. Zhou, F., Medh, R. D., and Thompson, E. B. (2000) J. Steroid Biochem. Mol. Biol. 73, 195-202
5. Miller, A. L., Webb, M. S., Copik, A. J., Wang, Y., Johnson, B. H., Kumar, R., and Thompson, E. B. (2005) Mol. Endocrinol. 19, 1569-1583
6. Miller, A. L., Garza, A. S., Johnson, B. H., and Thompson, E. B. (2007) Cancer Cell Int. 7, 3
7. Coffino, P., Bourne, H. R., Friedrich, U., Hochman, J., Insel, P. A., Lemaire, I., Melmon, K. L., and Tomkins, G. M. (1976) Recent Prog. Horm. Res. 32, 669-684
8. Thompson, E. B., Medh, R. D., Zhou, F., Ayala-Torres, S., Ansari, N., Zhang, W., and Johnson, B. H. (1999) J. Steroid Biochem. Mol. Biol. 69, 453-461
9. Zhang, L., and Insel, P. A. (2004) J. Biol. Chem. 279, 20858-20865
10. Medh, R. D., Saeed, M. F., Johnson, B. H., and Thompson, E. B. (1998) Cancer Res. 58, 3684-3693
11. Erlacher, M., Michalak, E. M., Kelly, P. N., Labi, V., Niederegger, H., Coultas, L., Adams, J. M., Strasser, A., and Villunger, A. (2005) Blood 106, 4131-4138
12. Lu, J., Quearry, B., and Harada, H. (2006) FEBS Lett. 580, 3539-3544
13. Bale, A. E. (2002) Annu. Rev. Genomics Hum. Genet. 3, 47-65
14. Chen, B. Y., Lin, D. P., Liu, J. Y., Chang, H., Huang, P. H., Chen, Y. L., and Chang, H. H. (2006) J. Biomed. Sci. 13, 373-384
15. Lau, J., Kawahira, H., and Hebrok, M. (2006) Cell Mol. Life Sci. 63, 642-652
16. Huang, S., He, J., Zhang, X., Bian, Y., Yang, L., Xie, G., Zhang, K., Tang, W., Stelter, A. A., Wang, Q., Zhang, H., and Xie, J. (2006) Carcinogenesis 27, 1334-1340
17. Thayer, S. P., di Magliano, M. P., Heiser, P. W., Nielsen, C. M., Roberts, D. J., Lauwers, G. Y., Qi, Y. P., Gysin, S., Fernandez-del Castillo, C., Yajnik, V., Antoniu, B., McMahon, M., Warshaw, A. L., and Hebrok, M. (2003) Nature 425, 851-856
18. Berman, D. M., Karhadkar, S. S., Maitra, A., Montes, D. O., Gerstenblith, M. R., Briggs, K., Parker, A. R., Shimada, Y., Eshleman, J. R., Watkins, D. N., and Beachy, P. A. (2003) Nature 425, 846-851
19. Ji, Z., Mei, F. C., Xie, J., and Cheng, X. (2007) J. Biol. Chem. 282, 14048-14055
20. Varas, A., Hager-Theodorides, A. L., Sacedon, R., Vicente, A., Zapata, A. G., and Crompton, T. (2003) Trends Immunol. 24, 197-206
21. Stewart, G. A., Lowrey, J. A., Wakelin, S. J., Fitch, P. M., Lindey, S., Dallman, M. J., Lamb, J. R., and Howie, S. E. (2002) J. Immunol. 169, 5451-5457
22. Lowrey, J. A., Stewart, G. A., Lindey, S., Hoyne, G. F., Dallman, M. J., Howie, S. E., and Lamb, J. R. (2002) J. Immunol. 169, 1869-1875
23. Trowbridge, J. J., Scott, M. P., and Bhatia, M. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 14134-14139
24. Regl, G., Kasper, M., Schnidar, H., Eichberger, T., Neill, G. W., Philpott, M. P., Esterbauer, H., Hauser-Kronberger, C., Frischauf, A. M., and Aberger, F. (2004) Cancer Res. 64, 7724-7731
25. Zawydiwski, R., Harmon, J. M., and Thompson, E. B. (1983) Cancer Res. 43, 3865-3873
26. Medh, R. D., Webb, M. S., Miller, A. L., Johnson, B. H., Fofanov, Y., Li, T., Wood, T. G., Luxon, B. A., and Thompson, E. B. (2003) Genomics 81, 543-555
27. Cheng, X., Phelps, C., and Taylor, S. S. (2001) J. Biol. Chem. 276, 4102-4108
28. Mei, F. C., Young, T. W., Liu, J., and Cheng, X. (2006) FASEB J. 20, 497-499
29. Oancea, M., Mazumder, S., Crosby, M. E., and Almasan, A. (2006) Methods Mol. Med. 129, 279-290
30. Bos, J. L. (2006) Trends Biochem. Sci. 31, 680-686
31. Qiao, J., Mei, F. C., Popov, V. L., Vergara, L. A., and Cheng, X. (2002) J. Biol. Chem. 277, 26581-26586
32. DiPilato, L. M., Cheng, X., and Zhang, J. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 16513-16518
33. Mei, F. C., and Cheng, X. D. (2005) Mol. Biosystems 1, 325-331
34. Sheng, T., Chi, S., Zhang, X., and Xie, J. (2006) J. Biol. Chem. 281, 9-12
35. Simons, S. S., Jr., Thompson, E. B., and Johnson, D. F. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 5167-5171
36. He, J., Sheng, T., Stelter, A. A., Li, C., Zhang, X., Sinha, M., Luxon, B. A., and Xie, J. (2006) J. Biol. Chem. 281, 35598-35602
37. Chen, J. K., Taipale, J., Young, K. E., Maiti, T., and Beachy, P. A. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 14071-14076
38. Fuld, S., Borland, G., and Yarwood, S. J. (2005) Exp. Cell Res. 309, 161-173
39. Mei, F. C., Qiao, J., Tsygankova, O. M., Meinkoth, J. L., Quilliam, L. A., and Cheng, X. (2002) J. Biol. Chem. 277, 11497-11504
40. Yu, S., Fan, F., Flores, S. C., Mei, F., and Cheng, X. (2006) Biochemistry 45, 15318-15326
41. Molofsky, A. V., Pardal, R., and Morrison, S. J. (2004) Curr. Opin. Cell Biol. 16, 700-707
42. Rubin, L. L., and de Sauvage, F. J. (2006) Nat. Rev. Drug Discov. 5, 1026-1033
43. Benazeraf, B., Chen, Q., Peco, E., Lobjois, V., Medevielle, F., Ducommun, B., and Pituello, F. (2006) Dev. Biol. 294, 133-147
44. Duman-Scheel, M., Weng, L., Xin, S., and Du, W. (2002) Nature 417, 299-304
45. Lobjois, V., Benazeraf, B., Bertrand, N., Medevielle, F., and Pituello, F. (2004) Dev. Biol. 273, 195-209
46. Pogoriler, J., Millen, K., Utset, M., and Du, W. (2006) Development 133, 3929-3937
47. Feng, Y. Z., Shiozawa, T., Miyamoto, T., Kashima, H., Kurai, M., Suzuki, A., Ying-Song, J., and Konishi, I. (2007) Clin. Cancer Res. 13, 1389-1398
48. Sanchez, P., Hernandez, A. M., Stecca, B., Kahler, A. J., DeGueme, A. M., Barrett, A., Beyna, M., Datta, M. W., Datta, S., and Altaba, A. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 12561-12566
49. Wang, Y., McMahon, A. P., and Allen, B. L. (2007) Curr. Opin. Cell Biol. 19, 159-165