A physiologically based kinetic (PBK) model describing plasma concentrations of quercetin and its metabolites in rats

Biochemical Pharmacology

Volumn 89, Issue 2, 2014, Pages 287-299

  Boonpawa, Rungnapa ^a   Spenkelink, Albertus ^a   Rietjens, Ivonne M C M ^a   Punt, Ans ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Absorption distribution metabolism excretion (ADME); Bioavailability; Physiologically based kinetic (PBK) modeling; Quercetin

Indexed keywords

4' O METHYLQUERCETIN; AGLYCONE; DRUG METABOLITE; GLUCOSIDE; QUERCETIN; QUERCETIN 3 METHYL ETHER; QUERCETIN 3 O GLUCURONIDE; QUERCETIN 3' O SULFATE; QUERCETIN 4' O GLUCOSIDE; QUERCETIN 7 O SULFATE; QUERCETIN AGLYCONE; QUERCETIN DIGLUCURONIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG METABOLISM; GLUCURONIDATION; IN VITRO STUDY; MALE; MATHEMATICAL MODEL; NONHUMAN; PHYSIOLOGICALLY BASED KINETIC MODEL; PRIORITY JOURNAL; RAT;

ABSORPTION DISTRIBUTION METABOLISM EXCRETION (ADME); BIOAVAILABILITY; PHYSIOLOGICALLY BASED KINETIC (PBK) MODELING; QUERCETIN;

ANIMALS; BIOLOGICAL AVAILABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; INTESTINAL ABSORPTION; MALE; MODELS, BIOLOGICAL; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84899417777     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.02.007     Document Type: Article

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