Bioavailabilities of quercetin-3-glucoside and quercetin-4'- glucoside do not differ in humans

Journal of Nutrition

Volumn 130, Issue 5, 2000, Pages 1200-1203

  Olthof, Margreet R ^a   Hollman, Peter C H ^a   Vree, Tom B ^b   Katan, Martijn B ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Bioavailability; Flavonols; Humans; Metabolism; Quercetin glucosides

Indexed keywords

ISOQUERCITRIN; QUERCETIN DERIVATIVE;

ABSORPTION; ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; BIOAVAILABILITY; DIETARY INTAKE; FEMALE; FOOD INTAKE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; NUTRIENT;

EID: 0034054933     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/130.5.1200     Document Type: Article

References (29)

1. Anonymous (1976) Analytical methods for atomic absorption spectrophotometry, Perkin-Elmer: Norwalk, CT.
2. Aziz, A. A., Edwards, C. A., Lean, M. E. & Crazier, A. (1998) Absorption and excretion of conjugated flavonols, including quercetin-4′-O-beta-glucoside and isorhamnetin-4′-O-beta-glucoside by human volunteers after the consumption of onions. Free Radical Res. 29: 257-269.
3. Bokkenheuser, V. D., Shackleton, C. H. & Winter, J. (1987) Hydrolysis of dietary flavonoid glycosides by strains of intestinal Bacteroides from humans. Biochem. J. 248: 953-956.
4. De Whalley, C., Rankin, S. M., Hoult, J. R., Jessup, W. & Leake, D. S. (1990) Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages. Biochem. Pharmacol. 39: 1743-1750.
5. Engelhardt, U., Finger, A., Herzig, B. & Kuhr, S. (1992) Determination of flavonol glycosides in black tea. Deutsche Lebensmittel-Rundschau 88: 69-73.
6. Gunata, Z., Bitteur, S., Brillout, J.-M., Bayonove, C. & Cordonnier, R. (1988) Sequential enzymatic hydrolysis of potentially aromatic glycosides from grapes. Carbohydrate Res. 184: 139-149.
7. Herrmann, K. (1976) Flavonols and flavones in food plants: a review. J. Fd. Technol. 11: 433-438.
8. Herrmann, K. (1988) On the occurrence of flavonol and flavone glycosides in vegetables. Z. Lebensm. Unters. Forsch. 186: 1-5.
9. Hertog, M. G., Feskens, E. J., Hollman, P. C., Katan, M. B. & Kromhout, D. (1993a) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342: 1007-1011.
10. Hertog, M., Hollman, P. & Katan, M. (1992) Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in The Netherlands. J. Agric. Fd. Chem. 40: 2379-2383.
11. Hertog, M. G., Hollman, P. C., Katan, M. B. & Kromhout, D. (1993b) Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr. Cancer 20: 21-29.
12. Hertog, M., Hollman, P. & van de Putte, B. (1993c) Content of potentially anticarcinogenic flavonoids of tea infusions, wines and fruit juices. J. Agric. Fd. Chem. 41: 1242-1246.
13. Hollman, P., Buysman, M. P., van Gameren, Y., Cnossen, E., de Vries, J. & Katan, M. (1999) The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Rad. Res. 31: 569-573.
14. Hollman, P. C., de Vries, J. H., van Leeuwen, S. D., Mengelers, M. J. & Katan, M. B. (1995) Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am. J. Clin. Nutr. 62: 1276-1282.
15. Hollman, P. C., van der Gaag, M., Mengelers, M. J., van Trijp, J., de Vries, J. & Katan, M. B. (1996a) Absorption and disposition kinetics of the dietary antioxidant quercetin in man. Free Radic. Biol. Med. 21: 703-707.
16. Hollman, P.C.H. & Katan, M. B. (1998) Absorption, metabolism and bioavailability of flavonoids. In: Flavonoids in Health and Disease (Rice Evans, C. & Packer, L., eds.) pp. 483-522. Marcel Dekker Inc, New York.
17. Hollman, P., van Trijp, J. & Buysman, M. (1996b) Fluorescence detection of flavonols in HPLC by postcolumn chelation with aluminum. Analyt. Chem. 68: 3511-3515.
18. Hollman, P. C., van Trijp, J., Buysman, M. N., van der Gaag, M., Mengelers, M. J., de Vries, J. & Katan, M. B. (1997) Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Lett. 418: 152-156.
19. Kiviranta, J., Huovinen, K. & Hiltunen, R. (1988) Variation in phenolic substances in onion. Acta Pharmaceutica Fennica 97: 67-72.
20. Kurosawa, Y., Ikeda, K. & Egami, F. (1973) Alpha-L-rhamnosidases of the liver of Turbo cornutus and Aspergillus niger. J. Biochem. 73: 31-37.
21. Manach, C., Morand, C., Crespy, V., Demigne, C., Taxier, O., Regerat, F. & Remesy, C. (1998) Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett. 426: 331-336.
22. Morand, C., Crespy, V., Manach, C., Besson, C., Demigne, C. & Remesy, C. (1998) Plasma metabolites of quercetin and their antioxidant properties. Am. J. Physiol. 275: R212-R219.
23. Proost, J. H. & Meijer, D. K. (1992) MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring. Comput. Biol. Med. 22: 155-163.
24. Rice Evans, C., Miller, N. J. & Paganga, G. (1996) Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med. 20: 933-956.
25. Sanchez-Castillo, C. P., Branch, W. J. & James, W.P.T. (1987a) A test of the validity of the lithium-marker technique for monitoring dietary sources of salt in man. Clin. Sci. 72: 87-94.
26. Sanchez-Castillo, C. P., Seidell, J. & James, W.P.T. (1987b) The potential use of lithium as a marker for the assessment of the sources of dietary salt: cooking studies and physiological experiments in men. Clin. Sci. 72: 81-86.
27. Williamson, G., Plumb, G. W., Uda, Y., Price, K. R. & Rhodes, M. J. (1996) Dietary quercetin glycosides: antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepalclc7 cells. Carcinogenesis 17: 2385-2387.
28. Yochum, L., Kushi, L., Meyer, K. & Folsom, A. (1999) Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women. Am. J. Epidemiol. 149: 943-949.
29. Zhu, B. T., Ezell, E. L. & Liehr, J. G. (1994) Catechol-O-methyltransferase-catalyzed rapid O-methylation of mutagenic flavonoids. Metabolic inactivation as a possible reason for their lack of carcinogenicity in vivo. J. Biol. Chem. 269: 292-299.