Intestinal first-pass metabolism of eperisone in the rat

Pharmaceutical Research

Volumn 18, Issue 8, 2001, Pages 1131-1137

  Mihara, K ^a   Matsumura, M ^a   Yoshioka, E ^a   Hanada, K ^a   Nakasa, H ^b   Ohmori, S ^b   Kitada, M ^b   Ogata, H ^a  

^a MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Bioavailability; Eperisone; Intestine; Metabolism; Microsomes; Rat

Indexed keywords

ALPHA NAPHTHOFLAVONE; CINNARIZINE; CYTOCHROME P450 1A1; EPERISONE;

ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG METABOLISM; DRUG TRANSFORMATION; FIRST PASS EFFECT; IN VITRO STUDY; IN VIVO STUDY; INTESTINE EPITHELIUM; INTESTINE PERFUSION; METABOLIC CLEARANCE RATE; MICROSOME; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; SMALL INTESTINE;

ALGORITHMS; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; IMMUNOBLOTTING; INTESTINAL ABSORPTION; INTESTINES; MALE; MICROSOMES; MICROSOMES, LIVER; PARASYMPATHOLYTICS; PERFUSION; PROPIOPHENONES; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0034802152     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010922925928     Document Type: Article

References (29)

1. Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine
2. Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism
3. The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin
4. Characterization of human small intestinal cytochromes P-450
5. A comparative study of xenobiotic-metabolizing enzymes in liver and intestine of various animal species
6. Induction of hepatic and extrahepatic cytoehrome P-450 and monooxygenase activities by N-substituted imidazoles
7. Xenobiotic metabolism and enzyme induction in isolated rat intestinal microsomes
8. Structural and functional assembly of rat intestinal cytochrome P-450 isozymes
9. Characterization of heme oxygenase in the small intestinal epithelium
10. Drug metabolism by the gastrointestinal mucosa
11. Metabolism of the human immunodeficiency virus protease inhibitors indinavir and ritonavir by human intestinal microsomes and expressed cytochrome P4503A4/3A5: Mechanism-based inactivation of cytochrome P4503A by ritonavir
12. Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: Comparison of Ki values and impact of CYP3A5 expression
13. Small intestinal cytochrome P450
14. Effects of E-0646 on cases of spasticity - A double blind comparision using tolperisone hydrochloride
15. Studies on the metabolic fate of 4′-ethyl-2-methyl-3-piperidinopropiophenone hydrochloride (1): Absorption, disposition and excretion in rats and guinea pigs
16. The metabolism of eperisone hydrochloride in laboratory aminals and man
17. Viability of the vascularly perfused, recirculating rat intestine and intestine-liver preparations
18. Cytochrome P-450 monooxygenase activities in human and rat liver microsomes
19. The carbon monoxide-binding pigment of liver microsomes
20. Protein measurement with the Folin phenol reagent
21. Hepatic triphosphopyridine nucleotide-cytochrome c reductase: Isolation, characterization and kinetic studies
22. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction
23. An adaptively stimulated o-demethylating system in rat liver microsomes and its kinetic properties
24. The o-dealkytation of 7-ethoxycoumarin by liver microsomes
25. Identification of glucocorticoid-induced cytochrome P-450 in the intestinal mucosa of rats and man
26. Immunochemical characterization and toxicological significance of P-450HFLb purified from human fetal livers
27. The absence of stereoselective P-glycoprotein-mediated transport of R/S-verapamil across the rat jejunum
28. Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin
29. Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2