Palmitic acid and DGAT1 deficiency enhance osteoclastogenesis, while oleic acid-induced triglyceride formation prevents it

Journal of Bone and Mineral Research

Volumn 29, Issue 5, 2014, Pages 1183-1195

  Drosatos Tampakaki, Zoi ^a   Drosatos, Konstantinos ^b   Siegelin, Yasemin ^a   Gong, Shan ^a   Khan, Salmiyeh ^c   Van Dyke, Thomas ^d   Goldberg, Ira J ^b   Schulze, P Christian ^b   Schulze Späte, Ulrike ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Division of Preventive Medicine and Nutrition Columbia University College of Physicians and Surgeons ^*  (United States)

^c Barnard College of Columbia University   (United States)

^d FORSYTH INSTITUTE   (United States)

Author keywords

DGAT1; osteoclastogenesis; palmitic acid; TNF ; triglycerides

Indexed keywords

DIACYLGLYCEROL ACYLTRANSFERASE 1; MESSENGER RNA; NEUTRALIZING ANTIBODY; OLEIC ACID; OSTEOCLAST DIFFERENTIATION FACTOR; PALMITIC ACID; SATURATED FATTY ACID; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; DGAT1 PROTEIN, MOUSE; DIACYLGLYCEROL ACYLTRANSFERASE; ENZYME INHIBITOR; FAT INTAKE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; BONE MASS; BONE STRUCTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIABETES MELLITUS; KNOCKOUT MOUSE; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; OBESITY; OSTEOCLAST; OSTEOCLASTOGENESIS; PROTEIN EXPRESSION; ANIMAL; CELL LINE; DRUG EFFECTS; FAT INTAKE; GENETICS; METABOLISM; PATHOLOGY; PHARMACOLOGY;

ANIMALS; ANTIBODIES, NEUTRALIZING; CELL DIFFERENTIATION; CELL LINE; DIACYLGLYCEROL O-ACYLTRANSFERASE; DIETARY FATS; ENZYME INHIBITORS; MICE; MICE, KNOCKOUT; OLEIC ACID; OSTEOCLASTS; PALMITIC ACID; TRIGLYCERIDES;

EID: 84899111431     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2150     Document Type: Article

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