Effect of diacylglycerols on osteoclastic bone resorption

Calcified Tissue International

Volumn 59, Issue 2, 1996, Pages 105-108

  Moonga, B S ^a   Stein, L S ^a   Kilb, J M ^a   Dempster, D W ^a,b  

^a HELEN HAYES HOSPITAL   (United States)

^b College of Physicians and Surgeons ^*  (United States)

Author keywords

Bone resorption; Diacylglycerol; Osteoclast

Indexed keywords

DIACYLGLYCEROL; PROTEIN KINASE C;

ARTICLE; HUMAN; HUMAN CELL; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; REGULATORY MECHANISM;

ANALYSIS OF VARIANCE; ANIMALS; BONE RESORPTION; CELL MOVEMENT; CELL SURVIVAL; CHICK EMBRYO; CHICKENS; DIGLYCERIDES; ENZYME ACTIVATION; OSTEOCLASTS; PROTEIN KINASE C; RATS; STEREOISOMERISM;

EID: 0029814066     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900095     Document Type: Article

References (15)

1. Murrills RJ, Stein LS, Horbert WR, Dempster DW (1992) Effects of phorbol myristate on rat and chick osteoclasts. J Bone Miner Res 7:415-423
2. Su Y, Chakraborty M, Nathanson M, Baron R (1992) Differential effects of the 3′,5′-cyclic adenosine monophosphate and protein kinase C pathways on the response of isolated rat osteoclasts to calcitonin. Endocrinology 131:1497-1502
3. 0 sensing in cultured osteoclasts. J Am Chem Soc 32:130-139
4. Gschwendr M, Kittstein W, Marks F (1991) Protein kinase C activation by phorbol esters: Do cysteine-rich regions and pseudosubstrate motifs play a role? Trends Biochem Sci 16: 167-169
5. Nomura H, Ase K, Sekiguchi K, Kikkawa U, Nishizuka Y, Nakano Y, Satoh T (1986) Stereospecificity of diacylglycerol for stimulus-response coupling in platelets. Biochem Biophys Res Commun 140:1143-1151
6. Rando R, Kishi Y (1992) Structural basis of protein kinase C activation by diacylglycerols and tumor promoters. J Am Chem Soc 31:2211-2218
7. Boyde A, Ali NN, Jones SJ (1984) Resorption of dentine by isolated osteoclasts in vitro. Br Dent J 156:210-220
8. Chambers TJ, Revell PA, Fuller K, Athanasou NA (1984) Resorption of bone by isolated rabbit osteoclasts. J Cell Sci 66:383-399
9. Dempster DW, Murrills RJ, Horbert WR, Arnett TR (1987) Biological activity of chicken calcitonin: effects of neonatal rat and embryonic chick osteoclasts. J Bone Miner Res 2:443-448
10. Rando RR, Young N (1984) The stereospecific activation of protein kinase C. Biochem Biophys Res Commun 122:818-823
11. Davis R, Ganong B, Bell R, Czech M (1985) sn-1,2-Dioctanoylglycerol. J Biol Chem 260:1562-1566
12. Go M, Sekiguchi K, Nomura H, Kikkawa U, Nishizuka Y (1987) Further studies on the specificity of diacylglycerol for protein kinase C activation. Biochem Biophys Res Commun 144:598-605
13. Fenton AJ, Kemp BE, Kent NG, Moseley JM, Zheng M, Rowe DJ, Britto JM, Martin TJ, Nicholson GC (1991) A carboxyl-terminal peptide from the parathyroid hormone-related protein inhibits bone resorption by osteoclasts. Endocrinology 129:1762-1768
14. Murrills RJ, Stein LS, Dempster DW (1995) Lack of significant effect of carboxyl-terminal parathyroid hormone-related peptide fragment on isolated rat and chick osteoclasts. Calcif Tissue Int 57:47-51
15. Kaji H, Sugimoto T, Kanatani M, Fukase M, Chihara K (1995) Carboxyl-terminal peptide from parathyroid hormone-related protein stimulates osteoclast-like cell formation. Endocrinology 136:842-848