Centrally located body fat is associated with lower bone mineral density in older Puerto Rican adults

American Journal of Clinical Nutrition

Volumn 94, Issue 4, 2011, Pages 1063-1070

  Bhupathiraju, Shilpa N ^a,b   Dawson Hughes, Bess ^b,c   Hannan, Marian T ^d   Lichtenstein, Alice H ^a,b   Tucker, Katherine L ^b,e  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL OBESITY; ADULT; AGED; ARTICLE; BODY COMPOSITION; BODY FAT; BODY WEIGHT; BONE; BONE DENSITY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR; FEMUR NECK; HUMAN; LUMBAR SPINE; MALE; OSTEOPENIA; OSTEOPOROSIS; PUERTO RICO; RISK; WEIGHT BEARING;

ABDOMINAL FAT; ADIPOSITY; AGED; BODY MASS INDEX; BONE DENSITY; BONE DISEASES, METABOLIC; BONE RESORPTION; BOSTON; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; FOLLOW-UP STUDIES; HISPANIC AMERICANS; HUMANS; MALE; MIDDLE AGED; OBESITY, ABDOMINAL; OSTEOPOROSIS; PUERTO RICO; RISK FACTORS; SEX FACTORS;

EID: 80053199319     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.111.016030     Document Type: Article

References (54)

1. National Osteoporosis Foundation. Prevalence report. Washington, DC. Available from: http://www.nof.org/advocacy/resources/prevalencereport (cited 27 September 2010).
2. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 2007;22: 465-75. (Pubitemid 46797130)
3. Ford ES, Li C, Zhao G, Tsai J. Trends in obesity and abdominal obesity among adults in the United States from 1999-2008. Int J Obes (Lond) 2010.
4. Looker AC, Flegal KM, Melton LJ III. Impact of increased overweight on the projected prevalence of osteoporosis in older women. Osteoporos Int 2007;18:307-13. (Pubitemid 46233176)
5. Looker AC, Melton LJ III, Harris TB, Borrud LG, Shepherd JA. Prevalence and trends in low femur bone density among older US adults: NHANES 2005-2006 compared with NHANES III. J Bone Miner Res 2010;25:64-71.
6. Jacobs EJ, Newton CC, Wang Y, Patel AV, McCullough ML, Campbell PT, Thun MJ, Gapstur SM.Waist circumference and all cause mortality in a large US cohort. Arch Intern Med 2010;170(15):1293-301.
7. Perry CD, Alekel DL, Ritland LM, Bhupathiraju SN, Stewart JW, Hanson LN, Matvienko OA, Kohut ML, Reddy MB, van Loan MD, et al. Centrally located body fat is related to inflammatory markers in healthy postmenopausal women. Menopause 2008;15:619-27.
8. Panagiotakos DB, Pitsavos C, Yannakoulia M, Chrysohoou C, Stefanadis C. The implication of obesity and central fat on markers of chronic inflammation: the ATTICA study. Atherosclerosis 2005; 183(2):308-15. (Pubitemid 41579282)
9. dos Santos RE, Aldrighi JM, Lanz JR, Ferezin PC, Marone MM. Relationship of body fat distribution by waist circumference, dual-energy X-ray absorptiometry and ultrasonography to insulin resistance by homeostasis model assessment and lipid profile in obese and non-obese postmenopausal women. Gynecol Endocrinol 2005;21(5):295-301. (Pubitemid 43041752)
10. Katzel LI, Busby-Whitehead MJ, Goldberg AP. Adverse effects of abdominal obesity on lipoprotein lipids in healthy older men. Exp Gerontol 1993;28:411-20. (Pubitemid 23226558)
11. Mattei J, Demissie S, Falcon LM, Ordovas JM, Tucker K. Allostatic load is associated with chronic conditions in the Boston Puerto Rican Health Study. Soc Sci Med 2010;70(12):1988-96.
12. Ohnishi H, Saitoh S, Akasaka H, Mitsumata K, Chiba M, Furugen M, Furukawa T, Mori M, Shimamoto K. Incidence of hypertension in individuals with abdominal obesity in a rural Japanese population: the Tanno and Sobetsu study. Hypertens Res 2008;31(7):1385-90.
13. Tucker KL, Falcon LM, Bianchi LA, Cacho E, Bermudez OI. Selfreported prevalence and health correlates of functional limitation among Massachusetts elderly Puerto Ricans, Dominicans, and non- Hispanic white neighborhood comparison group. J Gerontol A Biol Sci Med Sci 2000;55:M90-7. (Pubitemid 30165502)
14. Tucker KL, Mattei J, Noel SE, Collado BM, Mendez J, Nelson J, Griffith J, Ordovas JM, Falcon LM. The Boston Puerto Rican Health Study, a longitudinal cohort study on health disparities in Puerto Rican adults: challenges and opportunities. BMC Public Health 2010;10:107.
15. The International Society for Clinical Densitometry. Official positions of the International Society for Clinical Densitometry. West Hartford, CT: 2007:4-5.
16. White J, Harris SS, Dallal GE, Dawson-Hughes B. Precision of single vs bilateral hip bone mineral density scans. J Clin Densitom 2003;6(2): 159-62. (Pubitemid 36693810)
17. Paffenbarger RS, Wing AL, Hyde RT. Physical activity as an index of heart attack risk in college alumni. Am J Epidemiol 1978;108:161-75. (Pubitemid 9167225)
18. Paffenbarger RS Jr, Hyde RT, Wing AL, Lee IM, Jung DL, Kampert JB. The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. N Engl J Med 1993; 328:538-45. (Pubitemid 23053830)
19. Tucker KL, Bianchi LA, Maras J, Bermudez OI. Adaptation of a food frequency questionnaire to assess diets of Puerto Rican and non- Hispanic adults. Am J Epidemiol 1998;148:507-18. (Pubitemid 28411108)
20. Dawson-Hughes B, Dallal GE, Krall EA, Harris S, Sokoll LJ, Falconer G. Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Ann Intern Med 1991;115: 505-12.
21. Krall EA, Sahyoun N, Tannenbaum S, Dallal GE, Dawson-Hughes B. Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women. N Engl J Med 1989;321: 1777-83. (Pubitemid 20015570)
22. Willett WC, Howe GR, Kushi LH. Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 1997;65(4 suppl):1220S-8S; discussion 9S-31S.
23. World Health Organization. Available from: http://www.sheffield.ac. uk/FRAX/tool.jsp (cited 27 September 2010).
24. Hsu YH, Venners SA, Terwedow HA, Feng Y, Niu T, Li Z, Laird N, Brain JD, Cummings SR, Bouxsein ML, et al. Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr 2006;83(1): 146-54. (Pubitemid 44699248)
25. Zhao LJ, Liu YJ, Liu PY, Hamilton J, Recker RR, Deng HW. Relationship of obesity with osteoporosis. J Clin Endocrinol Metab 2007; 92(5):1640-6. (Pubitemid 46997165)
26. Reid IR. Fat and bone. Arch Biochem Biophys 2010;503(1):20-7.
27. Girard J, Lafontan M. Impact of visceral adipose tissue on liver metabolism and insulin resistance. Part II: Visceral adipose tissue production and liver metabolism. Diabetes Metab 2008;34(5):439-45.
28. Faulhaber GA, Premaor MO, Moser Filho HL, Silla LM, Furlanetto TW. Low bone mineral density is associated with insulin resistance in bone marrow transplant subjects. Bone Marrow Transplant 2009;43 (12):953-7.
29. Melton LJ III, Leibson CL, Achenbach SJ, Therneau TM, Khosla S. Fracture risk in type 2 diabetes: update of a population-based study. J Bone Miner Res 2008;23:1334-42. (Pubitemid 352040189)
30. Fain JN. Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review. Mediators Inflamm 2010;2010:513948.
31. Fain JN, Madan AK, Hiler ML, Cheema P, Bahouth SW. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 2004;145(5):2273-82. (Pubitemid 38535056)
32. Lapice E, Maione S, Patti L, Cipriano P, Rivellese AA, Riccardi G, Vaccaro O. Abdominal adiposity is associated with elevated C-reactive protein independent of BMI in healthy nonobese people. Diabetes Care 2009;32(9):1734-6.
33. Rexrode KM, Pradhan A, Manson JE, Buring JE, Ridker PM. Relationship of total and abdominal adiposity with CRP and IL-6 in women. Ann Epidemiol 2003;13(10):674-82. (Pubitemid 37346407)
34. Ding C, Parameswaran V, Udayan R, Burgess J, Jones G. Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study. J Clin Endocrinol Metab 2008;93(5):1952-8. (Pubitemid 351656543)
35. Kim BJ, Yu YM, Kim EN, Chung YE, Koh JM, Kim GS. Relationship between serum hsCRP concentration and biochemical bone turnover markers in healthy pre- and postmenopausal women. Clin Endocrinol (Oxf) 2007;67(1):152-8. (Pubitemid 46957455)
36. Koh JM, Khang YH, Jung CH, Bae S, Kim DJ, Chung YE, Kim GS. Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int 2005;16:1263-71. (Pubitemid 41396955)
37. Scheidt-Nave C, Bismar H, Leidig-Bruckner G, Woitge H, Seibel MJ, Ziegler R, Pfeilschifter J. Serum interleukin 6 is a major predictor of bone loss in women specific to the first decade past menopause. J Clin Endocrinol Metab 2001;86:2032-42. (Pubitemid 32472916)
38. Cauley JA, Danielson ME, Bounderau RM, Forrest KY, Zmuda JM, Pahor M, Tylavsky FA, Cummings SR, Harris TB, Newman AB. Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study. J Bone Miner Res 2007;22:1088-95. (Pubitemid 351339731)
39. Nomura K, Eto M, Kojima T, Ogawa S, Iijima K, Nakamura T, Araki A, Akishita M, Ouchi Y. Visceral fat accumulation and metabolic risk factor clustering in older adults. J Am Geriatr Soc 2010;58: 1658-63.
40. Samaras K, Botelho NK, Chisholm DJ, Lord RV. Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes. Obesity (Silver Spring) 2010;18(5):884-9.
41. Zhuo Q, Wang ZQ, Fu P, Piao JH, Tian Y, Xu J, Yang XG. Association between adiponectin and metabolic syndrome in older adults from major cities of China. Biomed Environ Sci 2010;23(1):53-61.
42. Oshima K, Nampei A, Matsuda M, Iwaki M, Fukuhara A, Hashimoto J, Yoshikawa H, Shimomura I. Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun 2005;331(2):520-6. (Pubitemid 40602668)
43. Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, Syversen U, Reseland JE. Adiponectin and its receptors are expressed in bone-forming cells. Bone 2004;35(4):842-9. (Pubitemid 39349215)
44. Williams GA, Wang Y, Callon KE, Watson M, Lin JM, Lam JB, Costa JL, Orpe A, Broom N, Naot D, et al. In vitro and in vivo effects of adiponectin on bone. Endocrinology 2009;150(8):3603-10.
45. Gilsanz V, Chalfant J, Mo AO, Lee DC, Dorey FJ, Mittelman SD. Reciprocal relations of subcutaneous and visceral fat to bone structure and strength. J Clin Endocrinol Metab 2009;94(9):3387-93.
46. Russell M, Mendes N, Miller KK, Rosen CJ, Lee H, Klibanski A, Misra M. Visceral fat is a negative predictor of bone density measures in obese adolescent girls. J Clin Endocrinol Metab 2010;95(3): 1247-55.
47. Huang JS, Rietschel P, Hadigan CM, Rosenthal DI, Grinspoon S. Increased abdominal visceral fat is associated with reduced bone density in HIV-infected men with lipodystrophy. AIDS 2001;15:975-82. (Pubitemid 32476664)
48. Seo HJ, Kim SG, Kim CS. Risk factors for bone mineral density at the calcaneus in 40-59 year-old male workers: a cross-sectional study in Korea. BMC Public Health 2008;8:253.
49. Kim CJ, Oh KW, Rhee EJ, Kim KH, Jo SK, Jung CH, Won JC, Park CY, Lee WY, Park SW, et al. Relationship between body composition and bone mineral density (BMD) in perimenopausal Korean women. Clin Endocrinol (Oxf) 2009;71(1):18-26.
50. Muraki S, Yamamoto S, Ishibashi H, Horiuchi T, Hosoi T, Orimo H, Nakamura K. Impact of degenerative spinal diseases on bone mineral density of the lumbar spine in elderly women. Osteoporos Int 2004;15: 724-8. (Pubitemid 39222655)
51. Jones G, Nguyen T, Sambrook PN, Kelly PJ, Eisman JA. A longitudinal study of the effect of spinal degenerative disease on bone density in the elderly. J Rheumatol 1995;22:932-6.
52. Goldacre MJ, Roberts SE, Yeates D. Mortality after admission to hospital with fractured neck of femur: database study. BMJ 2002;325: 868-9. (Pubitemid 35215258)
53. Savgan-Gurol E, Bredella M, Russell M, Mendes N, Klibanski A, Misra M. Waist to hip ratio and trunk to extremity fat (DXA) are better surrogates for IMCL and for visceral fat respectively than for subcutaneous fat in adolescent girls. Nutr Metab (Lond) 2010;7:86.
54. Ho JS, Cannaday JJ, Barlow CE, Willis B, Haskell WL, FitzGerald SJ. Comparative relation of general, central, and visceral adiposity measures for coronary artery calcium in subjects without previous coronary events. Am J Cardiol 2009;104(7):943-6.