Antagonists of the kappa opioid receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 9, 2014, Pages 2021-2032

  Urbano, Mariangela ^a   Guerrero, Miguel ^a   Rosen, Hugh ^a   Roberts, Edward ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Addictive disorders; Depression; OPRK antagonists; Short acting; Stress related disorders

Indexed keywords

ANTIDEPRESSANT AGENT; COCAINE; KAPPA OPIATE RECEPTOR ANTAGONIST; LY 2456302; LY 2795050; NICOTINE; PF 04455242; UNCLASSIFIED DRUG; KAPPA OPIATE RECEPTOR; LIGAND;

ADDICTION; ANXIETY DISORDER; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DEPRESSION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG PENETRATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; HUMAN; IC 50; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; MENTAL DISEASE; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION; TREATMENT RESISTANT DEPRESSION; ANIMAL; ANTAGONISTS AND INHIBITORS; ANXIETY; DRUG DEVELOPMENT; MENTAL STRESS; PROCEDURES; SUBSTANCE-RELATED DISORDERS;

ANIMALS; ANXIETY; DEPRESSION; DRUG DISCOVERY; HUMANS; LIGANDS; RECEPTORS, OPIOID, KAPPA; STRESS, PSYCHOLOGICAL; SUBSTANCE-RELATED DISORDERS;

EID: 84899060590     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.040     Document Type: Review

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