Tetrahydroquinoline derivatives as opioid receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 2, 2011, Pages 670-676

  Zhang, Cunyu ^a   Westaway, Susan M ^b   Speake, Jason D ^a,c   Bishop, Michael J ^a   Goetz, Aaron S ^a   Carballo, Luz Helena ^a   Hu, Mike ^a   Epperly, Andrea H ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c TARGACEPT INC   (United States)

Author keywords

Antagonist; Opioid; Tetrahydroquinoline

Indexed keywords

ALVIMOPAN; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; LY 255582; MU OPIATE RECEPTOR; NALTREXONE; OPIATE ANTAGONIST; TETRAHYDROQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; OBESITY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; QUINOLINES; RATS; RATS, LONG-EVANS; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78651243855     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.010     Document Type: Article

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