Synthesis and evaluation of 11-CLY2795050 as a k-opioid receptor antagonist radiotracer for PET imaging

Journal of Nuclear Medicine

Volumn 54, Issue 3, 2013, Pages 455-463

  Zheng, Ming Qiang ^a   Nabulsi, Nabeel ^a   Kim, Su Jin ^a   Tomasi, Giampaolo ^a   Lin, Shu Fei ^a   Mitch, Charles ^b   Quimby, Steven ^b   Barth, Vanessa ^b   Rash, Karen ^b   Masters, John ^b   Navarro, Antonio ^b   Seest, Eric ^b   Morris, Evan D ^a   Carson, Richard E ^a   Huang, Yiyun ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Antagonist; Kappa opioid receptor; PET; Radioligand; Synthesis

Indexed keywords

KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR ANTAGONIST; LY 2456302 CARBON 11; LY 2795050; LY 2795050 CARBON 11; LY2456302; NALTREXONE; RADIOLIGAND; TRACER; UNCLASSIFIED DRUG; CARBON; DIAGNOSTIC AGENT; LIGAND; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING ASSAY; DIAGNOSTIC IMAGING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EX VIVO STUDY; HAPLORHINI; IMAGE ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; RAT; RODENT; TANDEM MASS SPECTROMETRY; WILD TYPE; 129 MOUSE; ANIMAL; BRAIN; CHEMISTRY; DRUG ANTAGONISM; EVALUATION; METABOLISM; METHODOLOGY; MOUSE MUTANT; RADIOASSAY; RHESUS MONKEY; SCINTISCANNING; SPRAGUE DAWLEY RAT; SYNTHESIS;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; LIGANDS; MACACA MULATTA; MALE; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, KAPPA;

MLCS; MLOWN;

EID: 84874902902     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.112.109512     Document Type: Article

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