Identification of the first trans-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid κ receptor antagonist activity

Journal of Medicinal Chemistry

Volumn 44, Issue 17, 2001, Pages 2687-2690

  Thomas, J B ^a   Atkinson, R N ^a   Rothman, R B ^a   Fix, S E ^a   Mascarella, S W ^a   Vinson, N A ^a   Xu, H ^a   Dersch, C M ^a   Lu, Y F ^a   Cantrell, B E ^a   Zimmerman, D M ^a   Carroll, F I ^a  

^a RTI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIMETHYL 4 (3 HYDROXYPHENYL)PIPERIDINE DERIVATIVE; 7 HYDROXY N [1 [[4 (3 HYDROXYPHENYL) 3,4 DIMETHYL 1 PIPERIDINYL]METHYL] 2 METHYLPROPYL] 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINECARBOXAMIDE; KAPPA OPIATE RECEPTOR ANTAGONIST; NALOXONE; NALTREXONE; NALTRINDOLE; OPIATE RECEPTOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

CONTROLLED STUDY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; LETTER; NONHUMAN; RECEPTOR AFFINITY;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CLONING, MOLECULAR; GUINEA PIGS; HUMANS; ISOQUINOLINES; NARCOTIC ANTAGONISTS; PIPERIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 0035899186     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm015521r     Document Type: Letter

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