Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and Hit refinement strategy

ACS Chemical Neuroscience

Volumn 3, Issue 3, 2012, Pages 221-236

  Frankowski, Kevin J ^a   Hedrick, Michael P ^b   Gosalia, Palak ^b   Li, Kelin ^a   Shi, Shenghua ^b   Whipple, David ^a   Ghosh, Partha ^a   Prisinzano, Thomas E ^a   Schoenen, Frank J ^a   Su, Ying ^b   Vasile, S ^b   Sergienko, Eduard ^b   Gray, Wilson ^b   Hariharan, Santosh ^b   Milan, Loribelle ^b   Heynen Genel, Susanne ^b   Mangravita Novo, Arianna ^b   Vicchiarelli, Michael ^b   Smith, Layton H ^b   Streicher, John M ^d   Caron, Marc G ^c   Barak, Lawrence S ^c   Bohn, Laura M ^d   Chung, Thomas D Y ^b   Aubé, Jeffrey ^a   more..

^a UNIVERSITY OF KANSAS   (United States)

^b BURNHAM INSTITUTE   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

high throughput screening; Kappa opioid receptor agonist; kappa opioid receptor antagonist

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; KAPPA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; KETAZOCINE; SALVINORIN A;

ARTICLE; BINDING AFFINITY; CHIRALITY; HIGH THROUGHPUT SCREENING; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 84863393116     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn200128x     Document Type: Article

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