Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore

Journal of Medicinal Chemistry

Volumn 47, Issue 21, 2004, Pages 5069-5075

  Grundt, Peter ^a   Williams, Ian A ^a   Lewis, John W ^a   Husbands, Stephen M ^a  

^a University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIMETHYL 2 [(3 PHENYLPROP 2 ENYL)AMINO] 1,2,3,4 TETRAHYDRONAPHTHALEN 7 OL; 1,1 DIMETHYL 2 [METHYL(3 PHENYLPROP 2 ENYL)AMINO] 1,2,3,4 TETRAHYDRONAPHTHALEN 7 OL; 1,1 DIMETHYL 2 PROPYLAMINO 1,2,3,4 TETRAHYDRONAPHTHALEN 7 OL; 1,1 DIMETHYL 2 PROPYLMETHYLAMINO 1,2,3,4 TETRAHYDRONAPHTHALEN 7 OL; 2 [BIS (3 PHENYLPROP 2 ENYL)AMINO] 1,1 DIMETHYL 1,2,3,4 TETRAHYDRONAPHTHALEN 7 OL; 2 ALLYLAMINO 1,1 DIMETHYL 1,2,3,4 TETRAHYDRONAPHTHALEN 7 OL; 2 ALLYLMETHYLAMINO 1,1 DIMETHYL 1,2,3,4 TETRAHYDRONAPHTHALEN 7 OL; 2 AMINO 1,1 DIMETHYL 7 HYDROXYTETRALIN; 2 BIS CYCLOPROPYLMETHYLAMINO 1,1 DIMETHYL 1,2,3,4 TETRAHYDRONAPHTHALEN 7 OL; 2 CYCLOPROPYLMETHYLAMINO 1,1 DIMETHYL 1,2,3,4 TETRAHYDRONAPHTHALEN 7 OL; 2 CYCLOPROPYLMETHYLMETHYLAMINO 1,1 DIMETHYL 1,2,3,4 TETRAHYDRONAPHTHALEN 7 OL; 2 DIALLYLAMINO 1,1 DIMETHYL 1,2,3,4 TETRAHYDRONAPHTHALEN 7 OL; 2 DIMETHYLAMINO 1,1 DIMETHYL 1,2,3,4 TETRAHYDRONAPHTHALEN 7 OL; 2 DIPROPYLAMINO 1,1 DIMETHYL 1,2,3,4 TETRAHYDRONAPHTHALEN 7 OL; CINNAMIC ACID; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; NALTREXONE; NALTRINDOLE; OPIATE ANTAGONIST; PIPERIDINE DERIVATIVE; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG ANTAGONISM; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; PHARMACOPHORE; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION;

BINDING SITES; MODELS, MOLECULAR; NARCOTIC ANTAGONISTS; PIPERIDINES; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES;

EID: 4744365296     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040807s     Document Type: Article

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