Long-acting κ opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase

Journal of Biological Chemistry

Volumn 282, Issue 41, 2007, Pages 29803-29811

  Bruchas, Michael R ^a   Yang, Tao ^a,b   Schreiber, Selena ^a   DeFino, Mia ^a   Kwan, Steven C ^a   Li, Shuang ^a,c   Chavkin, Charles ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b 9th Bldg   (China)

^c ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GUANIDINONALTRINDOLE; NORBINALTORPHIMINE; OPIOID ANTAGONISTS; RECEPTOR SIGNALING;

ASSAYS; CELL CULTURE; PHOSPHORYLATION; PROTEINS;

DRUG PRODUCTS;

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BUPRENORPHINE; DIMETHYL 4 (3 HYDROXYPHENYL)PIPERIDINE; GUANIDINONALTRINDOLE; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR ANTAGONIST; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALOXONE; NORBINALTORPHIMINE; STRESS ACTIVATED PROTEIN KINASE; TRITIUM; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; CONTROLLED STUDY; CORPUS STRIATUM; EMBRYO; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SINGLE DRUG DOSE; SPINAL CORD; TAIL FLICK TEST; TAIL WITHDRAWAL ASSAY;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTHRACENES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KINETICS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PHOSPHORYLATION; RECEPTORS, OPIOID, KAPPA; SIGNAL TRANSDUCTION;

MUS;

EID: 35649027979     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M705540200     Document Type: Article

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