메뉴 건너뛰기




Volumn 9, Issue 1, 2014, Pages

Ras effector mutant expression suggest a negative regulator inhibits lung tumor formation

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CRE RECOMBINASE; ENHANCED GREEN FLUORESCENT PROTEIN; K RAS PROTEIN; LENTIVIRUS VECTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; RAF PROTEIN; RAL PROTEIN; KRAS PROTEIN, HUMAN; ONCOPROTEIN; RAS PROTEIN;

EID: 84899016927     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084745     Document Type: Article
Times cited : (18)

References (84)
  • 2
    • 34648815009 scopus 로고    scopus 로고
    • Lung cancer in never smokers - A different disease
    • DOI 10.1038/nrc2190, PII NRC2190
    • Sun S, Schiller JH, Gazdar AF (2007) Lung cancer in never smokers-a different disease. Nat Rev Cancer 7: 778-790. (Pubitemid 47463669)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.10 , pp. 778-790
    • Sun, S.1    Schiller, J.H.2    Gazdar, A.F.3
  • 3
    • 34548457234 scopus 로고    scopus 로고
    • The IASLC lung cancer staging project: Proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours
    • DOI 10.1097/JTO.0b013e31812f3c1a, PII 0124389420070800000006
    • Goldstraw P, Crowley J, Chansky K, Giroux DJ, Groome PA, et al. (2007) The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol 2: 706-714. (Pubitemid 47357522)
    • (2007) Journal of Thoracic Oncology , vol.2 , Issue.8 , pp. 706-714
    • Goldstraw, P.1    Crowley, J.2    Chansky, K.3    Giroux, D.J.4    Groome, P.A.5    Rami-Porta, R.6    Postmus, P.E.7    Rusch, V.8    Sobin, L.9
  • 4
    • 79551563284 scopus 로고    scopus 로고
    • International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma
    • Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, et al. (2011) International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 6: 244-285.
    • (2011) J Thorac Oncol , vol.6 , pp. 244-285
    • Travis, W.D.1    Brambilla, E.2    Noguchi, M.3    Nicholson, A.G.4    Geisinger, K.R.5
  • 6
    • 65249095599 scopus 로고    scopus 로고
    • The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS
    • Wong DW, Leung EL, So KK, Tam IY, Sihoe AD, et al. (2009) The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer 115: 1723-1733.
    • (2009) Cancer , vol.115 , pp. 1723-1733
    • Wong, D.W.1    Leung, E.L.2    So, K.K.3    Tam, I.Y.4    Sihoe, A.D.5
  • 7
    • 3843084078 scopus 로고    scopus 로고
    • The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
    • 2004/06/10 ed.
    • Bamford S, Dawson E, Forbes S, Clements J, Pettett R, et al. (2004) The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer. 2004/06/10 ed. pp. 355-358.
    • (2004) Br J Cancer , pp. 355-358
    • Bamford, S.1    Dawson, E.2    Forbes, S.3    Clements, J.4    Pettett, R.5
  • 8
    • 84868309107 scopus 로고    scopus 로고
    • The transcriptional landscape and mutational profile of lung adenocarcinoma
    • Seo JS, Ju YS, Lee WC, Shin JY, Lee JK, et al. (2012) The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res.
    • (2012) Genome Res
    • Seo, J.S.1    Ju, Y.S.2    Lee, W.C.3    Shin, J.Y.4    Lee, J.K.5
  • 11
    • 79952767398 scopus 로고    scopus 로고
    • Crizotinib, a small-molecule dual inhibitor of the c-Met and ALK receptor tyrosine kinases
    • Rodig SJ, Shapiro GI (2010) Crizotinib, a small-molecule dual inhibitor of the c-Met and ALK receptor tyrosine kinases. Curr Opin Investig Drugs 11: 1477- 1490.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1477-1490
    • Rodig, S.J.1    Shapiro, G.I.2
  • 13
    • 84863943675 scopus 로고    scopus 로고
    • Crizotinib for ALK-rearranged non-small cell lung cancer: A new targeted therapy for a new target
    • Gandhi L, Janne PA (2012) Crizotinib for ALK-rearranged non-small cell lung cancer: a new targeted therapy for a new target. Clin Cancer Res 18: 3737-3742.
    • (2012) Clin Cancer Res , vol.18 , pp. 3737-3742
    • Gandhi, L.1    Janne, P.A.2
  • 14
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • Eberhard DA, Johnson BE, Amler LC, Goddard AD, Heldens SL, et al. (2005) Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 23: 5900-5909.
    • (2005) J Clin Oncol , vol.23 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3    Goddard, A.D.4    Heldens, S.L.5
  • 15
    • 79960218807 scopus 로고    scopus 로고
    • Genotype-driven therapies for non-small cell lung cancer: Focus on EGFR, KRAS and ALK gene abnormalities
    • Gaughan EM, Costa DB (2011) Genotype-driven therapies for non-small cell lung cancer: focus on EGFR, KRAS and ALK gene abnormalities. Ther Adv Med Oncol 3: 113-125.
    • (2011) Ther Adv Med Oncol , vol.3 , pp. 113-125
    • Gaughan, E.M.1    Costa, D.B.2
  • 16
    • 65349107082 scopus 로고    scopus 로고
    • KRAS mutations in non-small cell lung cancer
    • Riely GJ, Marks J, Pao W (2009) KRAS mutations in non-small cell lung cancer. Proc Am Thorac Soc 6: 201-205.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 201-205
    • Riely, G.J.1    Marks, J.2    Pao, W.3
  • 17
    • 63149108552 scopus 로고    scopus 로고
    • Mutations and response to epidermal growth factor receptor inhibitors
    • Laurent-Puig P, Lievre A, Blons H (2009) Mutations and response to epidermal growth factor receptor inhibitors. Clin Cancer Res 15: 1133-1139.
    • (2009) Clin Cancer Res , vol.15 , pp. 1133-1139
    • Laurent-Puig, P.1    Lievre, A.2    Blons, H.3
  • 20
    • 0030772378 scopus 로고    scopus 로고
    • The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic ras mutants
    • DOI 10.1126/science.277.5324.333
    • Scheffzek K, Ahmadian MR, Kabsch W, Wiesmuller L, Lautwein A, et al. (1997) The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 277: 333-338. (Pubitemid 27450699)
    • (1997) Science , vol.277 , Issue.5324 , pp. 333-338
    • Scheffzek, K.1    Ahmadian, M.R.2    Kabsch, W.3    Wiesmuller, L.4    Lautwein, A.5    Schmitz, F.6    Wittinghofer, A.7
  • 21
    • 77950397231 scopus 로고    scopus 로고
    • Allosteric modulation of Ras positions Q61 for a direct role in catalysis
    • Buhrman G, Holzapfel G, Fetics S, Mattos C (2010) Allosteric modulation of Ras positions Q61 for a direct role in catalysis. Proc Natl Acad Sci U S A 107: 4931-4936.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 4931-4936
    • Buhrman, G.1    Holzapfel, G.2    Fetics, S.3    Mattos, C.4
  • 22
    • 0033635157 scopus 로고    scopus 로고
    • Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma
    • Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, et al. (2000) Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell 103: 931-943.
    • (2000) Cell , vol.103 , pp. 931-943
    • Pacold, M.E.1    Suire, S.2    Perisic, O.3    Lara-Gonzalez, S.4    Davis, C.T.5
  • 23
    • 2442689239 scopus 로고    scopus 로고
    • Signaling specificity by ras family GTPases is determined by the full spectrum of effectors they regulate
    • DOI 10.1128/MCB.24.11.4943-4954.2004
    • Rodriguez-Viciana P, Sabatier C, McCormick F (2004) Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate. Mol Cell Biol 24: 4943-4954. (Pubitemid 38668058)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.11 , pp. 4943-4954
    • Rodriguez-Viciana, P.1    Sabatier, C.2    McCormick, F.3
  • 26
    • 0030296617 scopus 로고    scopus 로고
    • A novel family of Ras-binding domains
    • DOI 10.1016/S0968-0004(96)30038-8, PII S0968000496300388
    • Ponting CP, Benjamin DR (1996) A novel family of Ras-binding domains. Trends Biochem Sci 21: 422-425. (Pubitemid 26393729)
    • (1996) Trends in Biochemical Sciences , vol.21 , Issue.11 , pp. 422-425
    • Ponting, C.P.1    Benjamin, D.R.2
  • 28
    • 0028948382 scopus 로고
    • Multiple Ras functions can contribute to mammalian cell transformation
    • White MA, Nicolette C, Minden A, Polverino A, Van Aelst L, et al. (1995) Multiple Ras functions can contribute to mammalian cell transformation. Cell 80: 533-541.
    • (1995) Cell , vol.80 , pp. 533-541
    • White, M.A.1    Nicolette, C.2    Minden, A.3    Polverino, A.4    Van Aelst, L.5
  • 29
    • 0030052368 scopus 로고    scopus 로고
    • Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
    • Joneson T, White MA, Wigler MH, Bar-Sagi D (1996) Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science 271: 810-812. (Pubitemid 26060736)
    • (1996) Science , vol.271 , Issue.5250 , pp. 810-812
    • Joneson, T.1    White, M.A.2    Wigler, M.H.3    Bar-Sagi, D.4
  • 30
    • 0029890896 scopus 로고    scopus 로고
    • Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation
    • Khosravi-Far R, White MA, Westwick JK, Solski PA, Chrzanowska-Wodnicka M, et al. (1996) Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol 16: 3923-3933.
    • (1996) Mol Cell Biol , vol.16 , pp. 3923-3933
    • Khosravi-Far, R.1    White, M.A.2    Westwick, J.K.3    Solski, P.A.4    Chrzanowska-Wodnicka, M.5
  • 31
    • 84875813017 scopus 로고    scopus 로고
    • Mouse models for lung cancer
    • Kwon MC, Berns A (2013) Mouse models for lung cancer. Mol Oncol 7: 165-177.
    • (2013) Mol Oncol , vol.7 , pp. 165-177
    • Kwon, M.C.1    Berns, A.2
  • 32
    • 84861728922 scopus 로고    scopus 로고
    • SnapShot: Lung cancer models
    • Farago AF, Snyder EL, Jacks T (2012) SnapShot: Lung cancer models. Cell 149: 246-246 e241.
    • (2012) Cell , vol.149
    • Farago, A.F.1    Snyder, E.L.2    Jacks, T.3
  • 35
    • 33847201454 scopus 로고    scopus 로고
    • A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors
    • Dankort D, Filenova E, Collado M, Serrano M, Jones K, et al. (2007) A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev 21: 379-384.
    • (2007) Genes Dev , vol.21 , pp. 379-384
    • Dankort, D.1    Filenova, E.2    Collado, M.3    Serrano, M.4    Jones, K.5
  • 38
    • 0035893318 scopus 로고    scopus 로고
    • Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
    • Fisher GH, Wellen SL, Klimstra D, Lenczowski JM, Tichelaar JW, et al. (2001) Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev 15: 3249-3262.
    • (2001) Genes Dev , vol.15 , pp. 3249-3262
    • Fisher, G.H.1    Wellen, S.L.2    Klimstra, D.3    Lenczowski, J.M.4    Tichelaar, J.W.5
  • 39
  • 40
    • 53149149440 scopus 로고    scopus 로고
    • Use of the viral 2A peptide for bicistronic expression in transgenic mice
    • Trichas G, Begbie J, Srinivas S (2008) Use of the viral 2A peptide for bicistronic expression in transgenic mice. BMC Biol 6: 40.
    • (2008) BMC Biol , vol.6 , pp. 40
    • Trichas, G.1    Begbie, J.2    Srinivas, S.3
  • 41
    • 84885416755 scopus 로고    scopus 로고
    • A modular lentiviral and retroviral construction system to rapidly generate vectors for gene expression and gene knockdown in vitro and in vivo
    • Geiling B, Vandal G, Posner AR, de Bruyns A, Dutchak KL, et al. (2013) A modular lentiviral and retroviral construction system to rapidly generate vectors for gene expression and gene knockdown in vitro and in vivo. PLoS One 8: e76279.
    • (2013) PLoS One , vol.8
    • Geiling, B.1    Vandal, G.2    Posner, A.R.3    De Bruyns, A.4    Dutchak, K.L.5
  • 42
    • 64749107970 scopus 로고    scopus 로고
    • Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors
    • Kutner RH, Zhang XY, Reiser J (2009) Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors. Nat Protoc 4: 495-505.
    • (2009) Nat Protoc , vol.4 , pp. 495-505
    • Kutner, R.H.1    Zhang, X.Y.2    Reiser, J.3
  • 43
    • 0037431266 scopus 로고    scopus 로고
    • Real-time quantitative reverse transcriptase-polymerase chain reaction as a method for determining lentiviral vector titers and measuring transgene expression
    • DOI 10.1089/104303403764539387
    • Lizee G, Aerts JL, Gonzales MI, Chinnasamy N, Morgan RA, et al. (2003) Realtime quantitative reverse transcriptase-polymerase chain reaction as a method for determining lentiviral vector titers and measuring transgene expression. Hum Gene Ther 14: 497-507. (Pubitemid 36438936)
    • (2003) Human Gene Therapy , vol.14 , Issue.6 , pp. 497-507
    • Lizee, G.1    Aerts, J.L.2    Gonzales, M.I.3    Chinnasamy, N.4    Morgan, R.A.5    Topalian, S.L.6
  • 44
    • 0038359205 scopus 로고    scopus 로고
    • Safety and efficiency of modulating paracellular permeability to enhance airway epithelial gene transfer in vivo
    • DOI 10.1089/104303403765255138
    • Johnson LG, Vanhook MK, Coyne CB, Haykal-Coates N, Gavett SH (2003) Safety and efficiency of modulating paracellular permeability to enhance airway epithelial gene transfer in vivo. Hum Gene Ther 14: 729-747. (Pubitemid 36623511)
    • (2003) Human Gene Therapy , vol.14 , Issue.8 , pp. 729-747
    • Johnson, L.G.1    Vanhook, M.K.2    Coyne, C.B.3    Haykal-Coates, N.4    Gavett, S.H.5
  • 45
    • 28544432790 scopus 로고    scopus 로고
    • The differential effects of mutant p53 alleles on advanced murine lung cancer
    • DOI 10.1158/0008-5472.CAN-05-2193
    • Jackson EL, Olive KP, Tuveson DA, Bronson R, Crowley D, et al. (2005) The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res 65: 10280-10288. (Pubitemid 41743720)
    • (2005) Cancer Research , vol.65 , Issue.22 , pp. 10280-10288
    • Jackson, E.L.1    Olive, K.P.2    Tuveson, D.A.3    Bronson, R.4    Crowley, D.5    Brown, M.6    Jacks, T.7
  • 46
    • 0030835430 scopus 로고    scopus 로고
    • Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21(Cip1)
    • Woods D, Parry D, Cherwinski H, Bosch E, Lees E, et al. (1997) Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol 17: 5598-5611. (Pubitemid 27357656)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.9 , pp. 5598-5611
    • Woods, D.1    Parry, D.2    Cherwinski, H.3    Bosch, E.4    Lees, E.5    McMahon, M.6
  • 47
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic Raf
    • Zhu J, Woods D, McMahon M, Bishop JM (1998) Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 12: 2997-3007. (Pubitemid 28469302)
    • (1998) Genes and Development , vol.12 , Issue.19 , pp. 2997-3007
    • Zhu, J.1    Woods, D.2    McMahon, M.3    Bishop, J.M.4
  • 48
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, et al. (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 12: 3008-3019. (Pubitemid 28469303)
    • (1998) Genes and Development , vol.12 , Issue.19 , pp. 3008-3019
    • Lin, A.W.1    Barradas, M.2    Stone, J.C.3    Van Aelst, L.4    Serrano, M.5    Lowe, S.W.6
  • 49
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a)
    • DOI 10.1016/S0092-8674(00)81902-9
    • Serrano M, Lin AW,McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593-602. (Pubitemid 27152402)
    • (1997) Cell , vol.88 , Issue.5 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 54
    • 34247897276 scopus 로고    scopus 로고
    • Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
    • DOI 10.1038/ncb1567, PII NCB1567
    • Sarkisian CJ, Keister BA, Stairs DB, Boxer RB, Moody SE, et al. (2007) Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat Cell Biol 9: 493-505. (Pubitemid 46696530)
    • (2007) Nature Cell Biology , vol.9 , Issue.5 , pp. 493-505
    • Sarkisian, C.J.1    Keister, B.A.2    Stairs, D.B.3    Boxer, R.B.4    Moody, S.E.5    Chodosh, L.A.6
  • 55
    • 1942469306 scopus 로고    scopus 로고
    • Mechanisms of Cell-Cycle Arrest in Spitz Nevi with Constitutive Activation of the MAP-Kinase Pathway
    • Maldonado JL, Timmerman L, Fridlyand J, Bastian BC (2004) Mechanisms of cell-cycle arrest in Spitz nevi with constitutive activation of the MAP-kinase pathway. Am J Pathol 164: 1783-1787. (Pubitemid 38529780)
    • (2004) American Journal of Pathology , vol.164 , Issue.5 , pp. 1783-1787
    • Maldonado, J.L.1    Timmerman, L.2    Fridlyand, J.3    Bastian, B.C.4
  • 56
    • 84865843828 scopus 로고    scopus 로고
    • The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway
    • Andreadi C, Cheung LK, Giblett S, Patel B, Jin H, et al. (2012) The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. Genes Dev 26: 1945-1958.
    • (2012) Genes Dev , vol.26 , pp. 1945-1958
    • Andreadi, C.1    Cheung, L.K.2    Giblett, S.3    Patel, B.4    Jin, H.5
  • 57
    • 84862544652 scopus 로고    scopus 로고
    • MEK1/2 inhibition elicits regression of autochthonous lung tumors induced by KRASG12D or BRAFV600E
    • Trejo CL, Juan J, Vicent S, Sweet-Cordero A, McMahon M (2012) MEK1/2 inhibition elicits regression of autochthonous lung tumors induced by KRASG12D or BRAFV600E. Cancer Res 72: 3048-3059.
    • (2012) Cancer Res , vol.72 , pp. 3048-3059
    • Trejo, C.L.1    Juan, J.2    Vicent, S.3    Sweet-Cordero, A.4    McMahon, M.5
  • 58
    • 84856527983 scopus 로고    scopus 로고
    • An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice
    • Kinross KM, Montgomery KG, Kleinschmidt M, Waring P, Ivetac I, et al. (2012) An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice. J Clin Invest 122: 553-557.
    • (2012) J Clin Invest , vol.122 , pp. 553-557
    • Kinross, K.M.1    Montgomery, K.G.2    Kleinschmidt, M.3    Waring, P.4    Ivetac, I.5
  • 59
    • 79952306961 scopus 로고    scopus 로고
    • The prognostic value of RASSF1A promoter hypermethylation in non-small cell lung carcinoma: A systematic review and meta-analysis
    • Wang J, Wang B, Chen X, Bi J (2011) The prognostic value of RASSF1A promoter hypermethylation in non-small cell lung carcinoma: a systematic review and meta-analysis. Carcinogenesis 32: 411-416.
    • (2011) Carcinogenesis , vol.32 , pp. 411-416
    • Wang, J.1    Wang, B.2    Chen, X.3    Bi, J.4
  • 60
    • 70349174971 scopus 로고    scopus 로고
    • The RASSF proteins in cancer; from epigenetic silencing to functional characterization
    • Richter AM, Pfeifer GP, Dammann RH (2009) The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Biochim Biophys Acta 1796: 114-128.
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 114-128
    • Richter, A.M.1    Pfeifer, G.P.2    Dammann, R.H.3
  • 61
    • 79952408564 scopus 로고    scopus 로고
    • N-terminal RASSF family: RASSF7-RASSF10
    • Underhill-Day N, Hill V, Latif F (2011) N-terminal RASSF family: RASSF7-RASSF10. Epigenetics 6: 284-292.
    • (2011) Epigenetics , vol.6 , pp. 284-292
    • Underhill-Day, N.1    Hill, V.2    Latif, F.3
  • 62
    • 0042232429 scopus 로고    scopus 로고
    • hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    • DOI 10.1016/S0092-8674(03)00549-X
    • Wu S, Huang J, Dong J, Pan D (2003) hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114: 445-456. (Pubitemid 37100993)
    • (2003) Cell , vol.114 , Issue.4 , pp. 445-456
    • Wu, S.1    Huang, J.2    Dong, J.3    Pan, D.4
  • 63
    • 23744458034 scopus 로고    scopus 로고
    • The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP
    • DOI 10.1016/j.cell.2005.06.007, PII S0092867405005520
    • Huang J, Wu S, Barrera J, Matthews K, Pan D (2005) The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 122: 421-434. (Pubitemid 41127143)
    • (2005) Cell , vol.122 , Issue.3 , pp. 421-434
    • Huang, J.1    Wu, S.2    Barrera, J.3    Matthews, K.4    Pan, D.5
  • 64
    • 70350502865 scopus 로고    scopus 로고
    • Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
    • Zhou D, Conrad C, Xia F, Park JS, Payer B, et al. (2009) Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 16: 425-438.
    • (2009) Cancer Cell , vol.16 , pp. 425-438
    • Zhou, D.1    Conrad, C.2    Xia, F.3    Park, J.S.4    Payer, B.5
  • 65
    • 33845426464 scopus 로고    scopus 로고
    • The Drosophila RASSF Homolog Antagonizes the Hippo Pathway
    • DOI 10.1016/j.cub.2006.10.060, PII S0960982206024353
    • Polesello C, Huelsmann S, Brown NH, Tapon N (2006) The Drosophila RASSF homolog antagonizes the hippo pathway. Curr Biol 16: 2459-2465. (Pubitemid 44894911)
    • (2006) Current Biology , vol.16 , Issue.24 , pp. 2459-2465
    • Polesello, C.1    Huelsmann, S.2    Brown, N.H.3    Tapon, N.4
  • 66
    • 0034681265 scopus 로고    scopus 로고
    • Ras1 promotes cellular growth in the Drosophila wing
    • Prober DA, Edgar BA (2000) Ras1 promotes cellular growth in the Drosophila wing. Cell 100: 435-446.
    • (2000) Cell , vol.100 , pp. 435-446
    • Prober, D.A.1    Edgar, B.A.2
  • 68
    • 24344435500 scopus 로고    scopus 로고
    • The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis
    • van der Weyden L, Tachibana KK, Gonzalez MA, Adams DJ, Ng BL, et al. (2005) The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis. Mol Cell Biol 25: 8356-8367.
    • (2005) Mol Cell Biol , vol.25 , pp. 8356-8367
    • Van Der Weyden, L.1    Tachibana, K.K.2    Gonzalez, M.A.3    Adams, D.J.4    Ng, B.L.5
  • 70
    • 11144267126 scopus 로고    scopus 로고
    • Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1
    • DOI 10.1126/science.1103233
    • O'Neill E, Rushworth L, Baccarini M, Kolch W (2004) Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science 306: 2267-2270. (Pubitemid 40024466)
    • (2004) Science , vol.306 , Issue.5705 , pp. 2267-2270
    • O'Neill, E.1    Rushworth, L.2    Baccarini, M.3    Kolch, W.4
  • 73
    • 9244228001 scopus 로고    scopus 로고
    • RASSF4/AD037 is a potential Ras effector/tumor suppressor of the RASSF family
    • DOI 10.1158/0008-5472.CAN-04-2065
    • Eckfeld K, Hesson L, Vos MD, Bieche I, Latif F, et al. (2004) RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family. Cancer Res 64: 8688-8693. (Pubitemid 39552084)
    • (2004) Cancer Research , vol.64 , Issue.23 , pp. 8688-8693
    • Eckfeld, K.1    Hesson, L.2    Vos, M.D.3    Bieche, I.4    Latif, F.5    Clark, G.J.6
  • 74
    • 84861918263 scopus 로고    scopus 로고
    • The RASSF3 Candidate Tumor Suppressor Induces Apoptosis and G1-S Cell-Cycle Arrest via p53
    • Kudo T, Ikeda M, Nishikawa M, Yang Z, Ohno K, et al. (2012) The RASSF3 Candidate Tumor Suppressor Induces Apoptosis and G1-S Cell-Cycle Arrest via p53. Cancer Res 72: 2901-2911.
    • (2012) Cancer Res , vol.72 , pp. 2901-2911
    • Kudo, T.1    Ikeda, M.2    Nishikawa, M.3    Yang, Z.4    Ohno, K.5
  • 75
    • 33847358769 scopus 로고    scopus 로고
    • The role of RASSF1A methylation in cancer
    • Epigenetic Markers
    • Hesson LB, Cooper WN, Latif F (2007) The role of RASSF1A methylation in cancer. Dis Markers 23: 73-87. (Pubitemid 46333640)
    • (2007) Disease Markers , vol.23 , Issue.1-2 , pp. 73-87
    • Hesson, L.B.1    Cooper, W.N.2    Latif, F.3
  • 76
    • 9644253000 scopus 로고    scopus 로고
    • CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer
    • DOI 10.1038/sj.onc.1207914
    • Irimia M, Fraga MF, Sanchez-Cespedes M, Esteller M (2004) CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer. Oncogene 23: 8695-8699. (Pubitemid 39576477)
    • (2004) Oncogene , vol.23 , Issue.53 , pp. 8695-8699
    • Irimia, M.1    Fraga, M.F.2    Sanchez-Cespedes, M.3    Esteller, M.4
  • 77
    • 64549157275 scopus 로고    scopus 로고
    • Rassf3 is responsible in part for resistance to mammary tumor development in neu transgenic mice
    • Jacquemart IC, Springs AE, Chen WY (2009) Rassf3 is responsible in part for resistance to mammary tumor development in neu transgenic mice. Int J Oncol 34: 517-528.
    • (2009) Int J Oncol , vol.34 , pp. 517-528
    • Jacquemart, I.C.1    Springs, A.E.2    Chen, W.Y.3
  • 79
    • 72949094426 scopus 로고    scopus 로고
    • Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity
    • Song H, Oh S, Oh HJ, Lim DS (2010) Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Biochem Biophys Res Commun 391: 969-973.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 969-973
    • Song, H.1    Oh, S.2    Oh, H.J.3    Lim, D.S.4
  • 80
    • 84866055989 scopus 로고    scopus 로고
    • A mouse model to identify cooperating signaling pathways in cancer
    • Musteanu M, Blaas L, Zenz R, Svinka J, Hoffmann T, et al. (2012) A mouse model to identify cooperating signaling pathways in cancer. Nat Methods 9: 897-900.
    • (2012) Nat Methods , vol.9 , pp. 897-900
    • Musteanu, M.1    Blaas, L.2    Zenz, R.3    Svinka, J.4    Hoffmann, T.5
  • 82
    • 0029160083 scopus 로고
    • A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine
    • Boussif O, Lezoualc'h F, Zanta MA, Mergny MD, Scherman D, et al. (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A 92: 7297-7301.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 7297-7301
    • Boussif, O.1    Lezoualc'h, F.2    Zanta, M.A.3    Mergny, M.D.4    Scherman, D.5
  • 83
    • 68149157175 scopus 로고    scopus 로고
    • Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase
    • DuPage M, Dooley AL, Jacks T (2009) Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. Nat Protoc 4: 1064-1072.
    • (2009) Nat Protoc , vol.4 , pp. 1064-1072
    • DuPage, M.1    Dooley, A.L.2    Jacks, T.3
  • 84
    • 0033922371 scopus 로고    scopus 로고
    • Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT)
    • Truett GE, Heeger P, Mynatt RL, Truett AA, Walker JA, et al. (2000) Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT). Biotechniques 29: 52, 54.
    • (2000) Biotechniques , vol.29
    • Truett, G.E.1    Heeger, P.2    Mynatt, R.L.3    Truett, A.A.4    Walker, J.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.