Cellular protection using Flt3 and PI3Ka inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity

Nature Communications

Volumn 5, Issue , 2014, Pages

  Kang, Yunyi ^a   Tiziani, Stefano ^b   Park, Goonho ^a   Kaul, Marcus ^a   Paternostro, Giovanni ^a  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLT3 LIGAND; GLUTAMIC ACID; GLUTATHIONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE ALPHA INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; POLYUNSATURATED FATTY ACID; PROTEIN TYROSINE KINASE FLT3 INHIBITOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CD135 ANTIGEN; ENZYME INHIBITOR; FLT3 PROTEIN, HUMAN; PIK3CA PROTEIN, HUMAN;

AMINO ACID; INHIBITOR; LIPID; MOLECULAR ANALYSIS; NERVOUS SYSTEM DISORDER; NEUROLOGY; OXIDATION; TOXICITY;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL TYPE; CONTROLLED STUDY; FATTY ACID METABOLISM; HYPERPOLARIZATION; LIPID PEROXIDATION; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; METABOLISM; OXIDATION REDUCTION REACTION;

APOPTOSIS; CELL LINE; ENZYME INHIBITORS; FMS-LIKE TYROSINE KINASE 3; GLUTAMIC ACID; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; REACTIVE OXYGEN SPECIES;

EID: 84898809189     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4672     Document Type: Article

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