PI3Kγ contributes to MEK1/2 activation in oxidative glutamate toxicity via PDK1

Journal of Neurochemistry

Volumn 127, Issue 1, 2013, Pages 139-148

  Ha, Jong Seong ^a   Kwon, Ki Sun ^a   Park, Sung Sup ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

oxidative glutamate toxicity; PDK1; PI3K

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE BETA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE SIGMA; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HIPPOCAMPUS; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE GLUTAMATE TOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

OXIDATIVE GLUTAMATE TOXICITY; PDK1; PI3KΓ;

3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES; ANIMALS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; ENZYME ACTIVATION; GLUTAMIC ACID; HUMANS; HYDROGEN PEROXIDE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASE 1; OXIDATION-REDUCTION; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PLASMIDS; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84884908645     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12364     Document Type: Article

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