Glutamate induces mitochondrial dynamic imbalance and autophagy activation: Preventive effects of selenium

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Kumari, Santosh ^a   Mehta, Suresh L ^a   Li, P Andy ^a  

^a NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; CELL MARKER; GLUTAMIC ACID; OXYGEN; PROTEIN DRP1; PROTEIN FIS1; PROTEIN LC3 II; REACTIVE OXYGEN METABOLITE; SODIUM SELENITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL COUNT; CELL FRACTIONATION; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; HYPERPOLARIZATION; MITOCHONDRIAL DYNAMIC IMBALANCE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXYGEN CONSUMPTION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE; CELL SURVIVAL; GLUTAMIC ACID; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; NEURONS; NEUROPROTECTIVE AGENTS; OXYGEN CONSUMPTION; REACTIVE OXYGEN SPECIES; SELENIUM;

EID: 84862549609     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039382     Document Type: Article

References (41)

1. Blandini F, Greenamyre JT, Nappi G, (1996) The role of glutamate in the pathophysiology of Parkinson's disease. Funct Neurol 11: 3-15.
2. Sattler R, Tymianski M, (2001) Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol Neurobiol 24: 107-129.
3. Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT, (1989) Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron 2: 1547-1558.
4. Wu S, Zhou F, Zhang Z, Xing D, (2011) Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins. FEBS J 278: 941-954.
5. Fukui M, Song JH, Choi J, Choi HJ, Zhu BT, (2009) Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells. Eur J Pharmacol 617: 1-11.
6. Chen H, Chan DC, (2009) Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases. Hum Mol Genet 18: R169-R176.
7. Chen H, Chomyn A, Chan DC, (2005) Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem 280: 26185-26192.
8. Jahani-Asl A, Cheung EC, Neuspiel M, MacLaurin JG, Fortin A, et al. (2007) Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death. J Biol Chem 282: 23788-23798.
9. Yu T, Robotham JL, Yoon Y, (2006) Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A 103: 2653-2658.
10. Kim H, Choi J, Ryu J, Park SG, Cho S, et al. (2009) Activation of autophagy during glutamate-induced HT22 cell death. Biochem Biophys Res Commun 388: 339-344.
11. Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T, (2001) Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2: 330-335.
12. Gomes LC, Scorrano L, (2008) High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy. Biochim Biophys Acta 1777: 860-866.
13. Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, et al. (2008) Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 27: 433-446.
14. Moghadaszadeh B, Beggs AH, (2006) Selenoproteins and their impact on human health through diverse physiological pathways. Physiology (Bethesda) 21: 307-315.
15. Rayman MP, (2000) The importance of selenium to human health. Lancet 356: 233-241.
16. Zafar KS, Siddiqui A, Sayeed I, Ahmad M, Salim S, et al. (2003) Dose-dependent protective effect of selenium in rat model of Parkinson's disease: neurobehavioral and neurochemical evidences. J Neurochem 84: 438-446.
17. Ansari MA, Ahmad AS, Ahmad M, Salim S, Yousuf S, et al. (2004) Selenium protects cerebral ischemia in rat brain mitochondria. Biol Trace Elem Res 101: 73-86.
18. Islam F, Zia S, Sayeed I, Zafar KS, Ahmad AS, (2002) Selenium-induced alteration of lipids, lipid peroxidation, and thiol group in circadian rhythm centers of rat. Biol Trace Elem Res 90: 203-214.
19. Gupta R, Singh M, Sharma A, (2003) Neuroprotective effect of antioxidants on ischaemia and reperfusion-induced cerebral injury. Pharmacol Res 48: 209-215.
20. Venardos K, Harrison G, Headrick J, Perkins A, (2004) Effects of dietary selenium on glutathione peroxidase and thioredoxin reductase activity and recovery from cardiac ischemia-reperfusion. J Trace Elem Med Biol 18: 81-88.
21. Panee J, Liu W, Nakamura K, Berry MJ, (2007) The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation. Int J Biol Sci 3: 335-341.
22. Ouyang YB, Carriedo SG, Giffard RG, (2002) Effect of Bcl-x(L) overexpression on reactive oxygen species, intracellular calcium, and mitochondrial membrane potential following injury in astrocytes. Free Radic Biol Med 33: 544-51.
23. Adrain C, Creagh EM, Martin SJ, (2001) Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. EMBO J 20: 6627-6636.
24. Mendelev N, Mehta SL, Li PA, (2011) Upregulation of human selenoprotein H in moraine hippocampal neuronal cells promotes mitochondrial biogenesis and functional performance. Mitochondrion 11: 6-82.
25. Sagara Y, Ishige K, Tsai C, Maher P, (2002) Tyrphostins protect neuronal cells from oxidative stress. J Biol Chem 277: 36204-36215.
26. Liu Y, Schubert DR, (2009) The specificity of neuroprotection by antioxidants. J Biomed Sci 16: 98-109.
27. Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K, (2007) Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem 282: 11521-9.
28. Otera H, Mihara K, (2011) Molecular mechanisms and physiologic functions of mitochondrial dynamics. J Biochem. 149: 241-51.
29. Savaskan NE, Bräuer AU, Kühbacher M, Eyüpoglu IY, Kyriakopoulos A, et al. (2003) Selenium deficiency increases susceptibility to glutamate-induced excitotoxicity. FASEB J 17: 112-114.
30. Yoon SO, Kim MM, Park SJ, Kim D, Chung J, et al. (2002) Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3K/Akt pathways. The FASEB J 16: 111-113.
31. Tan S, Sagara Y, Liu Y, Maher P, Schubert D, (1998) The regulation of reactive oxygen species production during programmed cell death. J Cell Biol. 141: 1423.
32. Tobaben S, Grohm J, Seiler A, Conrad M, Plesnila N, et al. (2011) Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death Differ. 18: 282-92.
33. Benard G, Bellance N, James D, Parrone P, Fernandez H, et al. (2007) Mitochondrial bioenergetics and structural network organization. J Cell Sci. 120: 838-48.
34. Goossens V, De Vos K, Vercammen D, Steemans M, Vancompernolle K, et al. (1999) Redox regulation of TNF signaling. Biofactors 10: 145-156.
35. Ben Jilani KE, Panee J, He Q, Berry MJ, Li PA, (2007) Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation. Int J Biol Sci 3: 198-204.
36. Tirosh O, Levy E, Reifen R, (2007) High selenium diet protects against TNBS-induced acute inflammation, mitochondrial dysfunction, and secondary necrosis in rat colon. Nutrition 23: 878-886.
37. Frank S, Gaume B, Bergmann-Leitner ES, Leitner WW, Robert EG, et al. (2001) The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell 1: 515-525.
38. Young KW, Piñon LG, Bampton ET, Nicotera P, (2010) Different pathways lead to mitochondrial fragmentation during apoptotic and excitotoxic cell death in primary neurons. J Biochem Mol Toxicol 24: 335-341.
39. Grohm J, Kim SW, Mamrak U, Tobaben S, Cassidy-Stone A, et al. (2012) Inhibition of Drp1 provides neuroprotection in vitro and in vivo. Cell Death Diff doi:10.1038/cdd.2012.18.
40. Rintoul GL, Filiano AJ, Brocard JB, Kress GJ, Reynolds IJ, (2003) Glutamate decreases mitochondrial size and movement in primary forebrain neurons. J Neurosci 23: 7881-7888.
41. Liu C, Gao Y, Barrett J, Hu B, (2010) Autophagy and protein aggregation after brain ischemia. J Neurochem 115: 68-78.