H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Woolley, John F ^a   Naughton, Ruth ^a   Stanicka, Joanna ^a   Gough, David R ^a   Bhatt, Lavinia ^a   Dickinson, Bryan C ^b   Chang, Christopher J ^b   Cotter, Thomas G ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; DIPHENYLIODONIUM SALT; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROGEN PEROXIDE; MIDOSTAURIN; PROTEASOME; PROTEIN KINASE PIM 1; PROTEIN P22PHOX; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STAT5 PROTEIN; UNCLASSIFIED DRUG; 3 BENZYL 7 (2 BENZOXAZOLYL)THIO 1,2,3 TRIAZOLO(4,5 D)PYRIMIDINE; 3-BENZYL-7-(2-BENZOXAZOLYL)THIO-1,2,3-TRIAZOLO(4,5-D)PYRIMIDINE; 6,7 DIHYDRO 5H PYRROLO(1,2 A)IMIDAZOLE; 6,7-DIHYDRO-5H-PYRROLO(1,2-A)IMIDAZOLE; BENZOXAZOLE DERIVATIVE; CYBA PROTEIN, HUMAN; DRUG DERIVATIVE; FLT3 PROTEIN, HUMAN; FLUORESCENT DYE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; IMIDAZOLE DERIVATIVE; PIM1 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE; SMALL INTERFERING RNA; STAUROSPORINE; TRIAZOLE DERIVATIVE;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CANCER CELL CULTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA STRUCTURE; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; INTERNAL TANDEM DUPLICATION; INTRACELLULAR SIGNALING; MITOCHONDRION; PROTEIN PROTEIN INTERACTION; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

BENZOXAZOLES; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; FLUORESCENT DYES; FMS-LIKE TYROSINE KINASE 3; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GLYCOGEN SYNTHASE KINASE 3; HUMANS; HYDROGEN PEROXIDE; IMIDAZOLES; LEUKEMIA, MYELOID, ACUTE; MITOCHONDRIA; MUTATION; NADPH OXIDASE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-PIM-1; PYRROLES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; STAUROSPORINE; TRIAZOLES;

EID: 84863743170     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034050     Document Type: Article

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