Palladacycle (BPC) antitumour activity against resistant and metastatic cell lines: The relationship with cytosolic calcium mobilisation and cathepsin B activity

European Journal of Medicinal Chemistry

Volumn 79, Issue , 2014, Pages 24-33

  Bechara, Alexandre ^a   Barbosa, Christiano M V ^a   Paredes Gamero, Edgar J ^a   Garcia, Daniel M ^a   Silva, Luís S ^a   Matsuo, Alisson L ^a   Nascimento, Fábio D ^b   Rodrigues, Elaine G ^a   Caires, Antonio C F ^c   Smaili, Soraya S ^a   Bincoletto, Claudia ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b Universidade Bandeirante de Sao Paulo   (Brazil)

^c UNIVERSIDADE DE MOGI DAS CRUZES   (Brazil)

Author keywords

Anticancer compounds; Biphosphinic Palladacycle Complex; Calcium signalling; Cathepsin B; Cytotoxicity; Lysosomal Membrane Permeabilisation

Indexed keywords

ANTINEOPLASTIC AGENT; BIPHOSPHINIC PALLADACYCLE COMPLEX; CALCIUM; CASPASE 3; CATHEPSIN B; PROTEIN BAX; UNCLASSIFIED DRUG; ORGANOMETALLIC COMPOUND;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CANCER RESISTANCE; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME MEMBRANE; MALE; METASTATIC MELANOMA; MOUSE; NONHUMAN; OSTEOSARCOMA; ANIMAL; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; INTRAPERITONEAL DRUG ADMINISTRATION; LYSOSOME; METABOLISM; NEOPLASMS, EXPERIMENTAL; PATHOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CALCIUM; CASPASE 3; CATHEPSIN B; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HUMANS; INJECTIONS, INTRAPERITONEAL; LYSOSOMES; MICE; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; ORGANOMETALLIC COMPOUNDS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84898764948     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.073     Document Type: Article

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