Cyclopalladated compounds as chemotherapeutic agents: Antitumor activity against a murine melanoma cell line

International Journal of Cancer

Volumn 107, Issue 3, 2003, Pages 498-504

  Rodrigues, Elaine G ^a   Silva, Luiz S ^a   Fausto, Daniela M ^b   Hayashi, Marina S ^b   Dreher, Simone ^b   Santos, Edson L ^a   Pesquero, João B ^a   Travassos, Luiz R ^a   Caires, Antonio C F ^b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDADE DE MOGI DAS CRUZES   (Brazil)

Author keywords

Antitumor activity; Apoptosis; B16F10 murine melanoma; Chemotherapy; Palladacycle biphosphinic complexes; Palladium

Indexed keywords

1 PHENYL 3 N,N DIMETHYLAMINE PROPINE; 1,2 ETHANEBIS(DIPHENYLPHOSPHINE); ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; CYCLOPALLADIUM DERIVATIVE; DNA; N,N DIMETHYL 1 PHENETHYLAMINE; PHENETHYLAMINE DERIVATIVE; PHENYL 2 PYRIDINYLACETYLENE; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CONTROLLED STUDY; DNA DEGRADATION; DRUG MECHANISM; DRUG SYNTHESIS; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; MELANOMA; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; TREATMENT OUTCOME;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; DNA, NEOPLASM; MALE; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; OXYGEN CONSUMPTION; PALLADIUM; TUMOR CELLS, CULTURED;

EID: 0142090675     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11434     Document Type: Article

References (27)

1. Mihich E, Ehrke MJ. Anticancer drugs plus cytokines: immunomodulation based therapies of mouse tumors. Intl. J. Immunopharm. 2000;22:1077-91
2. Rosenberg B, vanCamp L, Trosko JE, Mansour VH. Platinum compounds: a new class of potent antitumour agents. Nature 1969;222:385-6.
3. Rosenberg B, vanCamp L. The successful regression of large solid sarcoma 180 tumors by platinum compounds. Cancer Res 1970;30:1799-802.
4. Weiss RB, Christian MC. New cisplatin analogues in development. A review. Drugs 1993;46:360-77.
5. Di Francesco AM, Ruggiero A, Riccardi R. Cellular and molecular aspects of drugs of the future: oxaliplatin. Cell Mol Life Sci 2002;59:1914-27.
6. Gamelin E, Gamelin L, Bossi L, Quasthoff S. Clinical aspects and molecular basis of oxaliplatin neurotoxicity: current management and development of preventive measures. Semin Oncol 2002;29:21-33.
7. Guminski AD, Harnett PR, deFazio A. Scientists and clinicians test their metal-back to the future with platinum compounds. Lancet Oncol 2002;3:312-8.
8. Fontes APS, Almeida SG, Nader LA. Compostos de Platina em quimioterapia do câncer. Quimica Nova 1997;20:398-406.
9. McKeage MJ, Higgins JD 3rd, Kelland LR. Platinum and other metal coordination compounds in cancer chemotherapy. A commentary on the sixth international symposium: San Diego, California, 23-26 January 1991. Br J Cancer 1991;64:788-92.
10. Mandic A, Viktorsson K, Strandberg L, Heiden T, Hansson J, Linder S, Shoshan MC. Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in Cisplatin-induced apoptosis. Mol Cell Biol 2002;22:3003-13.
11. Mandic AK, Viktorsson K, Molin M, Akusjarvi G, Eguchi H, Hayashi S-I, Toi M, Hansson J, Linder S, Shoshan MC. Cisplatin induces the proapoptotic conformation of Bak in a DMEKK1-dependent manner. Mol Cell Biol 2001;21:3684-91.
12. Kharbanda S, Ren R, Pandey P, Shafman TD, Feller SM, Weichselbaum RR, Kufe DW. Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Nature 1995;376:785-8.
13. Nehmé A, Baskarna R, Aebi S, Fink D, Nebel S, Cenni B, Wang JYJ, Howell SB, Christen RD. Differential induction of c-Jun NH2-terminal kinase and c-Abl kinase in DNA mismatch repair-proficient and -deficient cells exposed to cisplatin. Cancer Res 1997;57:3253-7.
14. Navarro-Ranninger C, López-Solera I, Pérez JM, Masaguer JR, Alonso C. In vitro antitumor-activity of 2 isomeric cyclopalladated compounds derived from benzoylbenzylidenimines. Appl Organometal Chem 1993;7:57-61.
15. Higgins JD III, Neely L, Fricker S. Synthesis and cytotoxicity of some cyclometalated palladium complexes. J Inorg Biochem 1993;49:149-56.
16. Navarro-Ranninger C, López-Solera I, Pérez JM, Rodrigues J, Garcia-Ruano JL, Raithby PR, Masaguer JR, Alonso C. Analysis of 2 cycloplatinated compounds derived from N-(4-methoxyphenyl)-alpha-benzoylbenzylidenamine-comparison of the activity of these compounds with other isostructural cyclopalladated compounds. J Med Chem 1993;36:3795-801.
17. Caires ACF, Almeida ET, Mauro AE, Hemerly JP, Valentini SR. Synthesis and cytotoxicity of some cyclometallated palladium(II) complexes containing coordinated azide and diphosphines. Quimica Nova 1999;22:329-34.
18. Ryabov AD, Polyakov VA, Yatsimirsky AK. Reactions paths in the cyclopalladated NN-dialkylbenzylamine-substituted styrene system in acetic acid as solvent. The structure of palladated 2-dialkylamino-methylstilbenes. J Chem Soc Perkin Trans 1983;2:1503-9.
19. Ryabov AD, Kazankov GM, Kurzeev SA, Samuleev PV, Polyakov VA. Enantioselective cleavage of activated amino acid esters promoted by chiral palladacycles. Inorg Chim Acta 1998;280:57-61.
20. Aiub AC, Basso NR, Casagrande OL, Dupont J, Horner M, Bortoluzzi AJ, Maichle Mossmer C. Synthesis, characterization and reactivity of novel coordination compounds of Pd(II) and Pt (II) with phenyl-2-pyridinyl acetylene X-ray structure of trans-{Pt(O-NC5H4)C= C(Ph).Cl-2(Set(2))}. J Coord Chem 1996;40:35-44.
21. Crociani B, Boschi T, Pietropaolo R, Belluco U. Far-infrared study of palladium(II)-halogen complexes with chelating ligands containing nitrogen and sigma carbon as donor atoms. J Chem Soc(A)-Inorg Phys Theor 1970;3:531-42.
22. Rezler EM, Fenton RR, Esdale WJ, McKeage MJ, Russell PJ, Hambley TW. Preparation, characterization, DNA binding, and in vitro cytotoxicity of the enantiomers of the platinum (II) complexes N-methyl-, N-ethyl, and N,N-dimethyl-(R)- and (S)-3-aminohexahy-droazepinedichloroplatinum (II). J Med Chem 1997;40:3508-15.
23. Fenton RR, Esdale WJ, Er HM, O'Mara SM, McKeage MJ, Russell PJ, Hambley TW. Preparation, DNA binding, and in vitro cytotoxicity of a pair of enantiomeric platinum (II) complexes, (R)- and (S)-3-aminohexahydroazepine.dichloroplatinum (II). Crystal structure of the S enantiomer. J Med Chem 1997;40:1090-8.
24. Elliot K, Ge K, Du W, Prendergast GC. The c-Myc-interacting adaptor protein Bin 1 activates a caspase-independent cell death program. Oncogene 2000;19:4669-84.
25. Mathiasen IS, Jäätela M. Triggering caspase-independent cell death to combat cancer. Trends Mol Med 2002;8:212-20.
26. Cande C, Cecconi F, Dessen P, Kroemer G. Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci 2002;115:4727-34.
27. Leong C-O, Gaskell M, Martin EA, Heydon RT, Farmer PB, Bibby MC, Cooper PA, Double JA, Bradshaw TD, Stevens MFG. Antitumour 2-(4-aminophenyl) benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo. Br J Cancer 2003;88:470-7.