IP 3 receptor antagonist, 2-APB, attenuates cisplatin induced Ca 2+-influx in HeLa-S3 cells and prevents activation of calpain and induction of apoptosis

British Journal of Pharmacology

Volumn 151, Issue 8, 2007, Pages 1176-1186

  Splettstoesser, F ^a   Florea, A M ^a   Busselberg D ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Ca 2+ i; Anticancer drugs; Apoptosis; Calcium signalling; Calcium stores; Calpain; Carboplatin; Cisplatin; HeLa S3; IP 3 receptor; U2 OS

Indexed keywords

2 AMINOETHOXYDIPHENYLBORANE; CALCIUM; CALPAIN; CASPASE; CASPASE 8; CISPLATIN; HOE 33342; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL COUNT; CELL MEMBRANE; CONTROLLED STUDY; DRUG INHIBITION; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; EXTRACELLULAR CALCIUM; HELA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LASER MICROSCOPY; MEMBRANE CONDUCTANCE; OSTEOSARCOMA; PATCH CLAMP; PRIORITY JOURNAL; TUMOR CELL LINE; UTERINE CERVIX CARCINOMA; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; BORON COMPOUNDS; CALCIUM; CALCIUM SIGNALING; CALPAIN; CASPASE 8; CELL LINE, TUMOR; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; HELA CELLS; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MICROSCOPY, CONFOCAL;

EID: 34547870107     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707335     Document Type: Article

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