Studies on novel pyridine and 2-pyridone derivatives of N-arylpiperazine as α-adrenoceptor ligands

Medicinal Chemistry

Volumn 10, Issue 2, 2014, Pages 144-153

  Baran, Marzena ^a   Kȩpczyńska, Elzbieta ^a   Zylewski, Marek ^a   Siwek, Agata ^a   Bednarski, Marek ^a   Cegła, Marek Tadeusz ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

2 pyridone; Lipophilicity; N arylpiperazine derivatives; Pyridine; adrenoceptor ligands

Indexed keywords

1 [(6 BROMOPYRIDIN 2 YL)OXY] 3 [4 (2 FLUOROPHENYL) PIPERAZIN 1 YL]PROPAN 2 OL HYDROCHLORIDE; 1 [(6 BROMOPYRIDIN 2 YL)OXY] 3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPAN 2 OL; 1 [(6 BROMOPYRIDIN 2 YL)OXY] 3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPAN 2 OL HYDROCHLORIDE; 1 [(6 BROMOPYRIDIN 2 YL)OXY] 3 [4 (2 METHYLPHENYL) PIPERAZIN 1 YL]PROPAN 2 OL HYDROCHLORIDE; 2 ({4 [3 (TRIFLUOROMETHYL)PHENYL]PIPERAZIN 1 YL} METHYL) 2,3 DIHYDRO 5H [1,3]OXAZOLO[3,2 A]PYRIDIN 5 ONE; 2 PROPANOL; 2 PYRIDONE DERIVATIVE; 2 {[4 (2 FLUOROPHENYL)PIPERAZIN 1 YL]METHYL} 2,3 DIHYDRO 5H [1,3]OXAZOLO[3,2 A]PYRIDIN 5 ONE DIHYDROCHLORIDE; ADRENALIN; ADRENERGIC RECEPTOR; CHLORIDE; METHOXAMINE; N ARYLPIPERAZINE; NAFTOPIDIL; NORADRENALIN; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; 2-HYDROXYPYRIDINE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; LIGAND; PYRIDINE; PYRIDONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BLOOD PRESSURE; CONTROLLED STUDY; DRUG SYNTHESIS; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HYPERTENSION; IN VITRO STUDY; LIGAND BINDING; LIPOPHILICITY; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PHARMACODYNAMICS; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; MALE; METABOLISM; SYNTHESIS; WISTAR RAT;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; LIGANDS; MALE; MOLECULAR STRUCTURE; PIPERAZINES; PYRIDINES; PYRIDONES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84898754977     PISSN: 15734064     EISSN: 18756638     Source Type: Journal    
DOI: 10.2174/0929867320999131122114922     Document Type: Article

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