Synthesis of new piperazine-pyridazinone derivatives and their binding affinity toward α1-, α2-adrenergic and 5-HT1A serotoninergic receptors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 8, 2006, Pages 2828-2836

  Betti, Laura ^a   Zanelli, Marco ^b   Giannaccini, Gino ^a   Manetti, Fabrizio ^c   Schenone, Silvia ^d   Strappaghetti, Giovannella ^b  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

Author keywords

Adrenergic receptor ligands; 5 HT1A receptor ligands; Arylalkylpiperazines; Piperazine pyridazinones

Indexed keywords

2 [4 [5 CHLORO 4 [4 (2 FUOYL)PIPERAZIN 1 YL] 6 OXOPYRIDAZIN 1(6H) YL]BUTYL]PHTHALAZIN 1(2H) ONE; 4 CHLORO 5 [4 (2 FUROYL)PIPERAZIN 1 YL] 2 [4 [4 (2 ISOPROPOXYPHENYL) PIPERAZIN 1 YL]BUTYL]PYRIDAZIN 3(2H) ONE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; PIPERAZINE DERIVATIVE; PRAZOSIN; PYRIDAZINONE DERIVATIVE; RAUWOLSCINE; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; PHARMACODYNAMICS; RECEPTOR BINDING;

ANIMALS; CEREBRAL CORTEX; MAGNETIC RESONANCE SPECTROSCOPY; PIPERAZINES; PYRIDAZINES; RATS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, ALPHA-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33644749171     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.12.009     Document Type: Article

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