Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α 1-adrenoceptors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 17, 2011, Pages 5260-5276

  Pittalà, Valeria ^a   Siracusa, Maria A ^a   Modica, Maria N ^a   Salerno, Loredana ^a   Pedretti, Alessandro ^b   Vistoli, Giulio ^b   Cagnotto, Alfredo ^c   Mennini, Tiziana ^c   Romeo, Giuseppe ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

1 Adrenoceptors; 1H Pyrrolopyrimidine 2,4 dione; 5 HT 1A Receptors; Microwave synthesis; Molecular docking; QSAR

Indexed keywords

1H PYRROLOPYRIMIDINE 2,4 DIONE DERIVATIVE; 3 [2 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL] 6 (1,1 DIMETHYLETHYL) 1,5 DIHYDROPYRROLO[2,3 D]PYRIMIDINE 2,4 DIONE; 3 [2 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL] 6 (2 FURANYL) 1,5 DIHYDROPYRROLO[2,3 D]PYRIMIDINE 2,4 DIONE; 3 [2 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL] 7 (2 CHLOROPHENYL) 1,5 DIHYDROPYRROLO[2,3 D]PYRIMIDINE 2,4 DIONE; 3 [2 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL] 7 (4 CHLOROPHENYL) 1,5 DIHYDROPYRROLO[2,3 D]PYRIMIDINE 2,4 DIONE; 3 [2 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL] 7 (4 METHYLPHENYL) 1,5 DIHYDROPYRROLO[2,3 D]PYRIMIDINE 2,4 DIONE; 3 [2 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL] 7 PHENYL 1,5 DIHYDROPYRROLO[2,3 D]PYRIMIDINE 2,4 DIONE; 3 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] 7 PHENYL 1,5 DIHYDROPYRROLO[2,3 D]PYRIMIDINE 2,4 DIONE; 3 [[[(2 CHLOROETHYL)AMINO]CARBONYL]AMINO] 4 (2 CHLOROPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 3 [[[(2 CHLOROETHYL)AMINO]CARBONYL]AMINO] 4 (4 CHLOROPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 3 [[[(2 CHLOROETHYL)AMINO]CARBONYL]AMINO] 4 (4 METHYLPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 3 [[[(2 CHLOROETHYL)AMINO]CARBONYL]AMINO] 4 PHENYL 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 3 [[[(2 CHLOROETHYL)AMINO]CARBONYL]AMINO] 5 (1,1 DIMETHYLETHYL) 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 3 [[[(2 CHLOROETHYL)AMINO]CARBONYL]AMINO] 5 (2 FURANYL) 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 3 AMINO 4 (2 CHLOROPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 3 AMINO 4 (4 CHLOROPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 3 AMINO 4 (4 METHYLPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 6 (1,1 DIMETHYLETHYL) 3 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] 1,5 DIHYDROPYRROLO[2,3 D]PYRIMIDINE 2,4 DIONE; 6 (2 FURANYL) 3 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] 1,5 DIHYDROPYRROLO[2,3 D]PYRIMIDINE 2,4 DIONE; 6 [4 (1,1' BIPHENYL)] 3 [2 [4 (2 CHLOROPHENYL) 1 PIPERAZINYL]ETHYL] 1H PYRROLO[2,3 D]PYRIMIDINE 2,4(3H,7H) DIONE; 6 [4 (1,1' BIPHENYL)] 3 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 1H PYRROLO[2,3 D]PYRIMIDINE 2,4(3H,7H) DIONE; 7 (4 CHLOROPHENYL) 3 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] 1,5 DIHYDROPYRROLO[2,3 D]PYRIMIDINE 2,4 DIONE; ALPHA 1 ADRENERGIC RECEPTOR; LIGAND; N [2 CYANO 2 (2 CHLOROPHENYL)ETHENYL]GLYCINE ETHYL ESTER; N [2 CYANO 2 (4 CHLOROPHENYL)ETHENYL]GLYCINE ETHYL ESTER; N [2 CYANO 2 (4 METHYLPHENYL)ETHENYL]GLYCINE ETHYL ESTER; PYRROLOPYRIMIDINE DERIVATIVE; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING ASSAY; CONCENTRATION RESPONSE; DRUG DESIGN; DRUG POTENCY; DRUG PURIFICATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; MICROWAVE IRRADIATION; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR LIPOPHILICITY POTENTIAL INTERACTION SCORE; MOLECULAR MODEL; MOLECULAR WEIGHT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; COMPUTER SIMULATION; HUMANS; LIGANDS; MICROWAVES; MODELS, MOLECULAR; PYRIMIDINES; PYRROLES; RATS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, ADRENERGIC, ALPHA-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84860407549     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.043     Document Type: Article

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