Exploring the interplay of physicochemical properties, membrane permeability and giardicidal activity of some benzimidazole derivatives

European Journal of Medicinal Chemistry

Volumn 52, Issue , 2012, Pages 193-204

  Hernández Covarrubias, Carlos ^a,b   Vilchis Reyes, Miguel A ^a   Yépez Mulia, Lilian ^c   Sánchez Díaz, Remedios ^a,d   Navarrete Vázquez, Gabriel ^e   Hernández Campos, Alicia ^a   Castillo, Rafael ^a   Hernández Luis, Francisco ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b Ingeniería en Mantenimiento Industrial Universidad Tecnológica de Tlaxcala   (Mexico)

^c INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^d UNIVERSIDAD AUTÓNOMA DE BAJA CALIFORNIA   (Mexico)

^e UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

Author keywords

Benzimidazole; Caco 2 permeability; Giardia duodenalis; Lipophilicity; Solubility

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; METRONIDAZOLE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL STRAIN CACO 2; DRUG PENETRATION; DRUG SOLUBILITY; GIARDIA DUODENALIS; LIPOPHILICITY; MATHEMATICAL MODEL; MEMBRANE PERMEABILITY; NONHUMAN; PHYSICAL CHEMISTRY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANTIPROTOZOAL AGENTS; BENZIMIDAZOLES; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; DUODENUM; GIARDIA LAMBLIA; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; JEJUNUM; PHYSICOCHEMICAL PROCESSES; SOLUBILITY; TROPHOZOITES; WATER;

EID: 84860338963     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.014     Document Type: Article

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