Pharmacophore models based studies on the affinity and selectivity toward 5-HT1A with reference to α1-adrenergic receptors among arylpiperazine derivatives of phenytoin

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 3, 2011, Pages 1349-1360

  Handzlik, Jadwiga ^a   Szymańska, Ewa ^a   Ndza, Krystyna ^b   Kubacka, Monika ^c   Siwek, Agata ^c   Mogilski, Szczepan ^c   Handzlik, Jarosław ^d   Filipek, Barbara ^c   Kieć Kononowicz, Katarzyna ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c JAGIELLONIAN UNIVERSITY   (Poland)

^d CRACOW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

5 HT1A receptor; Arylpiperazine derivatives; N Triphenylmethyl protection; Phenytoin derivatives

Indexed keywords

1 (OXIRAN 2 YLMETHYL) 5,5 DIPHENYL 3 TRITYLIMIDAZOLIDINE 2,4 DIONE; 1 [2 HYDROXY 3 (4 PHENYLPIPERAZIN 1 YL)PROPYL] 5,5 DIPHENYL 3 TRITYLIMIDAZOLIDINE 2,4 DIONE; 1 [2 HYDROXY 3 (4 PHENYLPIPERAZIN 1 YL)PROPYL] 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 1 [2 HYDROXY 3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL] PROPYL] 5,5 DIPHENYL 3 TRITYLIMIDAZOLIDINE 2,4 DIONE; 1 [2 HYDROXY 3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL] 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 1 [3 [4 (2 ETHOXYPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 3 METHYL 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 1 [3 [4 (2 ETHOXYPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 5,5 DIPHENYL 3 TRITYLIMIDAZOLIDINE 2,4 DIONE; 1 [3 [4 (2 ETHOXYPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 5,5 DIPHENYLIMIDAZOLIDINE 2,4 DIONE; 2 [3 [2 HYDROXY 3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL] 2,5 DIOXO 4,4 DIPHENYLIMIDAZOLIDIN 1 YL]ACETIC ACID; 5,5 DIPHENYL 3 TRITYLIMIDAZOLIDINE 2,4 DIONE; ACETIC ACID; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; PHENYTOIN DERIVATIVE; PIPERAZINE DERIVATIVE; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING; MALE; MOLECULAR MECHANICS; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; HYDANTOINS; MODELS, MOLECULAR; PHENYTOIN; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, ADRENERGIC, ALPHA-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79551491321     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.051     Document Type: Article

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